Search Results - "McDevitt, Todd C."

Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential by Baraniak, Priya R., McDevitt, Todd C.

“…While traditional cell culture methods have relied on growing cells as monolayers, three-dimensional (3D) culture systems can provide a convenient in vitro…”
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Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment by Phillips-Cremins, Jennifer E., Sauria, Michael E.G., Sanyal, Amartya, Gerasimova, Tatiana I., Lajoie, Bryan R., Bell, Joshua S.K., Ong, Chin-Tong, Hookway, Tracy A., Guo, Changying, Sun, Yuhua, Bland, Michael J., Wagstaff, William, Dalton, Stephen, McDevitt, Todd C., Sen, Ranjan, Dekker, Job, Taylor, James, Corces, Victor G.

“…Understanding the topological configurations of chromatin may reveal valuable insights into how the genome and epigenome act in concert to control cell fate…”
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Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion by Zimmermann, Joshua A, Mcdevitt, Todd C

“…Abstract Background aims Mesenchymal stromal cells (MSCs) exhibit the inherent potential to regulate multiple signaling pathways and cell types that contribute…”
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Cell-derived matrices for tissue engineering and regenerative medicine applications by Fitzpatrick, Lindsay E, McDevitt, Todd C

“…The development and application of decellularized extracellular matrices (ECM) has grown rapidly in the fields of cell biology, tissue engineering and…”
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Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation by Wilson, Jenna L., McDevitt, Todd C.

“…Cell microencapsulation has been utilized for decades as a means to shield cells from the external environment while simultaneously permitting transport of…”
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Gelatin methacrylate microspheres for controlled growth factor release by Nguyen, Anh H., McKinney, Jay, Miller, Tobias, Bongiorno, Tom, McDevitt, Todd C.

“…[Display omitted] Gelatin has been commonly used as a delivery vehicle for various biomolecules for tissue engineering and regenerative medicine applications…”
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Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids by Silva, Ana C, Matthys, Oriane B, Joy, David A, Kauss, Mara A, Natarajan, Vaishaali, Lai, Michael H, Turaga, Diwaker, Blair, Andrew P, Alexanian, Michael, Bruneau, Benoit G, McDevitt, Todd C

“…During embryogenesis, paracrine signaling between tissues in close proximity contributes to the determination of their respective cell fate(s) and development…”
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Dynamic intercellular transport modulates the spatial patterning of differentiation during early neural commitment by Glen, Chad M., McDevitt, Todd C., Kemp, Melissa L.

“…The initiation of heterogeneity within a population of phenotypically identical progenitors is a critical event for the onset of morphogenesis and…”
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Scalable culture of human pluripotent stem cells in 3D by McDevitt, Todd C.

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Axial elongation of caudalized human organoids mimics aspects of neural tube development by Libby, Ashley R G, Joy, David A, Elder, Nicholas H, Bulger, Emily A, Krakora, Martina Z, Gaylord, Eliza A, Mendoza-Camacho, Frederico, Butts, Jessica C, McDevitt, Todd C

“…Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-posterior body axis establishment and subsequent spinal cord…”
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Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration by Hettiaratchi, Marian H, Krishnan, Laxminarayanan, Rouse, Tel, Chou, Catherine, McDevitt, Todd C, Guldberg, Robert E

“…Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fracture nonunions, large bone defects, and…”
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Alginate encapsulation parameters influence the differentiation of microencapsulated embryonic stem cell aggregates by Wilson, Jenna L., Najia, Mohamad Ali, Saeed, Rabbia, McDevitt, Todd C.

“…ABSTRACT Pluripotent embryonic stem cells (ESCs) have tremendous potential as tools for regenerative medicine and drug discovery, yet the lack of processes to…”
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Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery by Miller, Tobias, Goude, Melissa C., McDevitt, Todd C., Temenoff, Johnna S.

“…Glycosaminoglycans (GAGs) are linear, negatively charged polysaccharides that interact with a variety of positively charged growth factors. In this review…”
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Differentiation of V2a interneurons from human pluripotent stem cells by Butts, Jessica C., McCreedy, Dylan A., Martinez-Vargas, Jorge Alexis, Mendoza-Camacho, Frederico N., Hookway, Tracy A., Gifford, Casey A., Taneja, Praveen, Noble-Haeusslein, Linda, McDevitt, Todd C.

“…The spinal cord consists of multiple neuronal cell types that are critical to motor control and arise from distinct progenitor domains in the developing neural…”
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Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation by Bratt-Leal, Andrés M, Carpenedo, Richard L, Ungrin, Mark D, Zandstra, Peter W, McDevitt, Todd C

“…Abstract Biomaterials are increasingly being used to engineer the biochemical and biophysical properties of the extracellular stem cell microenvironment in…”
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Rotary Suspension Culture Enhances the Efficiency, Yield, and Homogeneity of Embryoid Body Differentiation by Carpenedo, Richard L., Sargent, Carolyn Y., McDevitt, Todd C.

“…Embryonic stem (ES) cells hold great promise as a robust cell source for cell‐based therapies and as a model of early embryonic development. Current…”
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Histone h1 depletion impairs embryonic stem cell differentiation by Zhang, Yunzhe, Cooke, Marissa, Panjwani, Shiraj, Cao, Kaixiang, Krauth, Beth, Ho, Po-Yi, Medrzycki, Magdalena, Berhe, Dawit T, Pan, Chenyi, McDevitt, Todd C, Fan, Yuhong

“…Pluripotent embryonic stem cells (ESCs) are known to possess a relatively open chromatin structure; yet, despite efforts to characterize the chromatin…”
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Diseased, differentiated and difficult: Strategies for improved engineering of in vitro neurological systems by Elder, Nicholas, Fattahi, Faranak, McDevitt, Todd C., Zholudeva, Lyandysha V.

“…The rapidly growing field of cellular engineering is enabling scientists to more effectively create in vitro models of disease and develop specific cell types…”
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Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system by Natarajan, Vaishaali, Simoneau, Camille R, Erickson, Ann L, Meyers, Nathan L, Baron, Jody L, Cooper, Stewart, McDevitt, Todd C, Ott, Melanie

“…Hepatitis C virus (HCV) remains a global public health challenge with an estimated 71 million people chronically infected, with surges in new cases and no…”
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Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation by Bratt-Leal, Andrés M., Carpenedo, Richard L., McDevitt, Todd C.

“…Embryonic stem cells (ESCs) are pluripotent cells capable of differentiating into all somatic and germ cell types. The intrinsic ability of pluripotent cells…”
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