Search Results - "McDermott, Kelsey"
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Adult neurogenesis improves spatial information encoding in the mouse hippocampus
Published in Nature communications (30-07-2024)“…Adult neurogenesis is a unique form of neuronal plasticity in which newly generated neurons are integrated into the adult dentate gyrus in a process that is…”
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A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments
Published in Journal of chemical neuroanatomy (01-10-2024)“…Locus coeruleus (LC) neurons send their noradrenergic axons across multiple brain regions, including neocortex, subcortical regions, and spinal cord. Many…”
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Decoding individual identity from brain activity elicited in imagining common experiences
Published in Nature communications (20-11-2020)“…Everyone experiences common events differently. This leads to personal memories that presumably provide neural signatures of individual identity when events…”
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Delayed formation of neural representations of space in aged mice
Published in Aging cell (01-09-2023)“…Aging is associated with cognitive deficits, with spatial memory being very susceptible to decline. The hippocampal dentate gyrus (DG) is important for…”
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Transcriptional regulation of neural stem cell expansion in the adult hippocampus
Published in eLife (04-01-2022)“…Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors (TFs) in RGLs…”
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A HIGH-RESOLUTION 3D RECONSTRUCTION OF THE LOCUS COERULEUS IN ADULT AND AGED RHESUS MACAQUES
Published in IBRO neuroscience reports (01-10-2023)Get full text
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The mediating role of hippocampal networks on stress regulation in amnestic mild cognitive impairment
Published in Neurobiology of stress (01-02-2019)“…To examine the role of the hippocampus in stress regulation in older adults with amnestic mild cognitive impairment (aMCI). This study combined resting-state…”
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Donor-derived vasculature is required to support neocortical cell grafts after stroke
Published in Stem cell research (01-03-2022)“…•Dissociated donor vascular cells in neural transplants form vessels.•Donor-derived vessels fuse with host vessels to circulate blood in neural…”
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Treadmill-based task for assessing spatial memory in head-fixed mice
Published in STAR protocols (17-09-2021)“…Several mouse in vivo neuronal recording techniques require head fixation. Head-fixed treadmill walking can be used to design tasks that enable the study of…”
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Corrigendum to “Donor-derived vasculature is required to support neocortical cell grafts after stroke” [59 (2022) 102642]
Published in Stem cell research (01-04-2022)Get full text
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Aging and Neuroimmune Mechanisms in Hippocampal Representations of Space
Published 01-01-2023“…The hippocampus is essential for spatial learning and memory, and neurons in this brain region form a cognitive map of the external environment. Spatial memory…”
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Dissertation -
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Retrosplenial cortex microglia and perineuronal net densities are associated with memory impairment in aged rhesus macaques
Published in Cerebral cortex (New York, N.Y. 1991) (04-04-2023)“…Abstract Synapse loss and altered plasticity are significant contributors to memory loss in aged individuals. Microglia, the innate immune cells of the brain,…”
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Attitudes Toward Computers Moderate the Effect of Computerized Cognitive Trainings in Oldest-Old Senior Living Center Residents
Published in The American journal of geriatric psychiatry (01-03-2021)“…•What is the primary question addressed by this study? We sought to examine whether a computerized platform involving games and leisure activities would…”
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Brain structural connectomes indicate shared neural circuitry involved in subjective experience of cognitive and physical fatigue in older adults
Published in Brain imaging and behavior (01-12-2020)“…Cumulative evidence suggests the existence of common processes underlying subjective experience of cognitive and physical fatigue. However, mechanistic…”
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CSF FROM PROGRESSIVE-MS PATIENTS STIMULATES MICROGLIAL ACTIVATION PATHWAYS IN VIVO AND IN VITRO (P5.334)
Published in Neurology (05-04-2016)“…Abstract only…”
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Cognitive fatigue and cortical-striatal network in old age
Published in Aging (Albany, NY.) (17-04-2019)“…Cognitive fatigue (CF) is among the most common and disturbing aging symptoms, and substantially interferes with activities demanding sustained mental effort…”
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Transglutaminase-6 is an autoantigen in progressive multiple sclerosis and is upregulated in reactive astrocytes
Published in Multiple sclerosis (01-11-2017)“…Background: Transglutaminase-6 (TGM6), a member of the transglutaminase enzyme family, is found predominantly in central nervous system (CNS) neurons under…”
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Transglutaminase 6 is a potential biomarker of disease activity and astrocytic proliferation in MS. (P5.212)
Published in Neurology (06-04-2015)“…Abstract only…”
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A MEDIATIONAL MODEL OF STRESS IN HIPPOCAMPAL NETWORKS IN MILD COGNITIVE IMPAIRMENT
Published in Alzheimer's & dementia (01-07-2017)Get full text
Journal Article