Search Results - "McDaniel, Nellie K"
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AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer
Published in BMC cancer (23-04-2022)“…The receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) is overexpressed and an important therapeutic target in Head and Neck cancer (HNC)…”
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AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer
Published in Clinical cancer research (15-08-2020)“…Radiation and cetuximab are therapeutics used in management of head and neck squamous cell carcinoma (HNSCC). Despite clinical success with these modalities,…”
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MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents
Published in Molecular cancer therapeutics (01-11-2018)“…The TAM (TYRO3, AXL, MERTK) family receptor tyrosine kinases (RTK) play an important role in promoting growth, survival, and metastatic spread of several tumor…”
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Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol
Published in Molecular cancer therapeutics (01-01-2018)“…Overexpression and activation of the EGFR have been linked to poor prognosis in several human cancers. Cetuximab is a mAb against EGFR that is used for the…”
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From Bench to Bedside: A Team's Approach to Multidisciplinary Strategies to Combat Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma
Published in Journal of clinical medicine (10-10-2024)“…Head and neck squamous cell carcinoma (HNSCC) is diagnosed in more than 71,000 patients each year in the United States, with nearly 16,000 associated deaths…”
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Abstract A128: AXL mediates cetuximab resistance through tyrosine 821 and activation of c-Abl kinase in head and neck cancer
Published in Molecular cancer therapeutics (01-12-2019)“…Abstract Radiation and cetuximab are therapeutics used in the management of head and neck squamous cell carcinoma (HNSCC). Despite clinical success with these…”
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Abstract A140: MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents
Published in Molecular cancer therapeutics (01-01-2018)“…Abstract The TAM family of receptor tyrosine kinases (RTKs) has been discovered to play a predominant role in promoting the growth, survival, and metastatic…”
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