Search Results - "McDaid, H M"

N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties by Qian, X, Anzovino, A, Kim, S, Suyama, K, Yao, J, Hulit, J, Agiostratidou, G, Chandiramani, N, McDaid, H M, Nagi, C, Cohen, H W, Phillips, G R, Norton, L, Hazan, R B

“…N-cadherin and HER2/neu were found to be co-expressed in invasive breast carcinomas. To test the contribution of N-cadherin and HER2 in mammary tumor…”
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Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines by McDaid, H M, Horwitz, S B

“…Activation of the mitogen-activated protein kinase (MAPK) pathway in HeLa and Chinese hamster ovary cells after treatment with paclitaxel (Taxol) and other…”
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Peripheral blood mononuclear and tumor cell pharmacodynamics of the novel epothilone B analogue, ixabepilone by Mani, S., McDaid, H.M., Grossman, A., Muggia, F., Goel, S., Griffin, T., Colevas, D., Horwitz, S.B., Egorin, M.J.

“…Background: We previously demonstrated that peak microtubule bundle formation (MBF) in peripheral blood mononuclear cells (PBMCs) occurs at the end of drug…”
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Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer by MCDAID, H. M, CAIRNS, M. T, ATKINSON, R. J, MCALEER, S, HARKIN, D. P, GILMORE, P, JOHNSTON, P. G

“…The primary element in the cAMP signal transduction pathway is the cAMP-dependent protein kinase (PKA). Expression of the RIα subunit of type I PKA is elevated…”
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Synergistic interaction between paclitaxel and 8-chloro-adenosine 3', 5'-monophosphate in human ovarian carcinoma cell lines by MCDAID, H. M, JOHNSTON, P. G

“…Taxol is a unique anticancer agent that is used in treatment of advanced ovarian cancer. Taxol exposure results in the polymerization and stabilization of the…”
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Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines by MCDAID, H. M, BHATTACHARYA, S. K, CHEN, X.-T, LIFENG HE, SHEN, H.-J, GUTTERIDGE, C. E, HORWITZ, S. B, DANISHEFSKY, S. J

“…Eleutherobin, a natural product, is an antimitotic agent that promotes the polymerization of stable microtubules. Although its mechanism of action is similar…”
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Taxol and Discodermolide Represent a Synergistic Drug Combination in Human Carcinoma Cell Lines by Martello, L A, McDaid, H M, Regl, D L, Yang, C P, Meng, D, Pettus, T R, Kaufman, M D, Arimoto, H, Danishefsky, S J, Smith, 3rd, A B, Horwitz, S B

“…Recently, three natural products have been identified, the epothilones, eleutherobin, and discodermolide, whose mechanism of action is similar to that of Taxol…”
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Combined MEK and mTOR suppression is synergistic in human NSCLC and is mediated via inhibition of protein translation by McDaid, H. M., Legrier, M., Yang, C. H., Yan, H. G., Lopez-Barcons, L., Keller, S. M., Horwitz, S. B.

“…Abstract only 10615 Background: Lung cancer is a heterogeneous disease characterized by the acquisition of somatic mutations in numerous protein kinases,…”
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Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants by MCDAID, Hayley M, LOPEZ-BARCONS, Lluis, GROSSMAN, Aaron, LIA, Marie, KELLER, Steven, PEREZ-SOLER, Roman, HORWITZ, Susan Band

“…Taxol may contribute to intrinsic chemoresistance by activating the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)…”
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Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-Bearing Mice by HUANG, Gloria S, LOPEZ-BARCONS, Lluis, FREEZE, B. Scott, SMITH, Amos B, GOLDBERG, Gary L, HORWITZ, Susan Band, MCDAID, Hayley M

“…Purpose: To evaluate the drug combination of discodermolide and Taxol in human ovarian cancer cells and in an in vivo model of ovarian carcinoma. Experimental…”
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Validation of the Pharmacodynamics of BMS-247550, an Analogue of Epothilone B, during a Phase I Clinical Study by MCDAID, Hayley M, MANI, Sridhar, SHEN, Heng-Jia, MUGGIA, Franco, SONNICHSEN, Daryl, HORWITZ, Susan Band

“…The primary aims of this study were to evaluate the timecourse and dose response of microtubule bundle formationin peripheral blood mononuclear cells (PBMCs)…”
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Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer by McDaid, H M, Cairns, M T, Atkinson, R J, McAleer, S, Harkin, D P, Gilmore, P, Johnston, P G

“…The primary element in the cAMP signal transduction pathway is the cAMP-dependent protein kinase (PKA). Expression of the RIalpha subunit of type I PKA is…”
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