Search Results - "McDIARMID, A"

Habituation Is More Than Learning to Ignore: Multiple Mechanisms Serve to Facilitate Shifts in Behavioral Strategy by McDiarmid, Troy A., Yu, Alex J., Rankin, Catharine H.

“…Recent work indicates that there are distinct response habituation mechanisms that can be recruited by different stimulation rates and that can underlie…”
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Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation by McDiarmid, Troy A., Belmadani, Manuel, Liang, Joseph, Meili, Fabian, Mathews, Eleanor A., Mullen, Gregory P., Hendi, Ardalan, Wong, Wan-Rong, Rand, James B., Mizumoto, Kota, Haas, Kurt, Pavlidis, Paul, Rankin, Catharine H.

“…A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and growing number of candidate risk genes and gene variants of unknown…”
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Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements by Chardon, Florence M., McDiarmid, Troy A., Page, Nicholas F., Daza, Riza M., Martin, Beth K., Domcke, Silvia, Regalado, Samuel G., Lalanne, Jean-Benoît, Calderon, Diego, Li, Xiaoyi, Starita, Lea M., Sanders, Stephan J., Ahituv, Nadav, Shendure, Jay

“…CRISPR-based gene activation (CRISPRa) is a strategy for upregulating gene expression by targeting promoters or enhancers in a tissue/cell-type specific…”
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Hazards of the Health Care Sector: Looking Beyond Infectious Disease by McDiarmid, Melissa A.

“…Possessing every hazard class, the health care sector poses significant health threats to its workforce in both high-resource settings and low- and…”
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Rapid assessment of the temporal function and phenotypic reversibility of neurodevelopmental disorder risk genes in Caenorhabditis elegans by Kepler, Lexis D, McDiarmid, Troy A, Rankin, Catharine H

“…Recent studies have indicated that some phenotypes caused by decreased function of select neurodevelopmental disorder (NDD) risk genes can be reversed by…”
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Peel-1 negative selection promotes screening-free CRISPR-Cas9 genome editing in Caenorhabditis elegans by McDiarmid, Troy A, Au, Vinci, Moerman, Donald G, Rankin, Catharine H

“…Improved genome engineering methods that enable automation of large and precise edits are essential for systematic investigations of genome function. We…”
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Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction by Post, Kathryn L., Belmadani, Manuel, Ganguly, Payel, Meili, Fabian, Dingwall, Riki, McDiarmid, Troy A., Meyers, Warren M., Herrington, Caitlin, Young, Barry P., Callaghan, Daniel B., Rogic, Sanja, Edwards, Matthew, Niciforovic, Ana, Cau, Alessandro, Rankin, Catharine H., O’Connor, Timothy P., Bamji, Shernaz X., Loewen, Christopher J. R., Allan, Douglas W., Pavlidis, Paul, Haas, Kurt

“…Functional variomics provides the foundation for personalized medicine by linking genetic variation to disease expression, outcome and treatment, yet its…”
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Chromosome 5 and 7 Abnormalities in Oncology Personnel Handling Anticancer Drugs by McDiarmid, Melissa A., Oliver, Marc S., Roth, Tracy S., Rogers, Bonnie, Escalante, Carmen

“…Objective: To determine the frequency of "signature" chromosomal abnormalities in oncology workers handling anticancer drugs. Methods: Peripheral blood from…”
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Preventing Occupational Exposures to Antineoplastic Drugs in Health Care Settings by Connor, Thomas H, McDiarmid, Melissa A

“…The toxicity of antineoplastic drugs has been well known since they were introduced in the 1940s. Because most antineoplastic drugs are nonselective in their…”
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CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance by McDiarmid, Troy A, Au, Vinci, Loewen, Aaron D, Liang, Joseph, Mizumoto, Kota, Moerman, Donald G, Rankin, Catharine H

“…Our ability to sequence genomes has vastly surpassed our ability to interpret the genetic variation we discover. This presents a major challenge in the…”
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Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers by Connor, Thomas H., DeBord, D. Gayle, Pretty, Jack R., Oliver, Marc S., Roth, Tracy S., Lees, Peter S. J., Krieg, Edward F., Rogers, Bonnie, Escalante, Carmen P., Toennis, Christine A., Clark, John, Johnson, Belinda, McDiarmid, Melissa A.

“…Objective: This study evaluated health care worker exposure to antineoplastic drugs. Methods: A cross-sectional study examined environmental samples from…”
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Identifying and exploring factors influencing career choice, recruitment and retention of anaesthesia trainees in the UK by Moore, J N, McDiarmid, A J, Johnston, P W, Cleland, J A

“…BackgroundMany acute hospital specialties are experiencing low recruitment and high attrition of trainees. Understanding what is important to current trainees…”
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Long-Term Outcomes of Heartware Left Ventricular Assist Device Decommissioning for Myocardial Recovery by Wang, L., Woods, A., Robinson-Smith, N., Tovey, S., McDiarmid, A., Parry, G., Schueler, S., MacGowan, G.

“…Left ventricular assist device (LVAD) decommissioning reduces the risks associated with long-term LVAD support without subjecting patients to a major…”
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Elevation of Right-Sided Pressures and Right Ventricular Echocardiographic Parameters: Predictors of Exercise Limitation in Patients with Implanted Continuous Flow Left Ventricular Assist Devices by Bouzas-Cruz, N., Gonzalez-Fernandez, O., Koshy, A., Okwose, N., Woods, A., Robinson-Smith, N., Tovey, S., McDiarmid, A., Parry, G., Schueler, S., Jakovljevic, D., MacGowan, G.

“…To determine parameters of exercise intolerance in a group of patients with HeartWare Ventricular Assist Device(HVAD) compared to a group of heart…”
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Hepatitis B serology testing and vaccination for Gambian healthcare workers: A pilot study by Manjang, Buba, Keita, Ebrima, Bittaye, Sheikh Omar, Jallow, Bubacarr, Mbye, Sambou, Badjie, Abdoulie B., Touray, Ibrahim, Bojang, Lamin, Tamba, Saydiba, Kebbeh, Lamin, Bojang, Lamin M., Kanyi, Sanna, Sanneh, Modou Lamin, Ceesay, Njaga, Gaitens, Joanna M., LeBuhn, Hanna M., McDiarmid, Melissa A.

“…Abstract only…”
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Depleted uranium exposure and health effects in Gulf War veterans by Squibb, Katherine S, McDiarmid, Melissa A

“…creatinine, however, indicate the need for continued surveillance of these DU-exposed veterans…”
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Cardiovascular MRI evidence of reduced systolic function and reduced LV mass in rheumatoid arthritis: impact of disease phenotype by Bissell, L. A., Erhayiem, B., Hensor, E. M. A., Fent, G., Burska, A., McDiarmid, A. K., Swoboda, P. P., Donica, H., Plein, S., Buch, M. H., Greenwood, J. P., Andrews, J.

“…The accelerated risk of cardiovascular disease (CVD) in Rheumatoid Arthritis (RA) requires further study of the underlying pathophysiology and determination of…”
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Airborne transmission of SARS-CoV-2 by Prather, Kimberly A, Marr, Linsey C, Schooley, Robert T, McDiarmid, Melissa A, Wilson, Mary E, Milton, Donald K

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Mutagenicity monitoring following battlefield exposures: Longitudinal study of HPRT mutations in gulf war i veterans exposed to depleted uranium by Albertini, Richard J., Vacek, Pamela M., Carter, Elizabeth W., Nicklas, Janice A., Squibb, Katherine S., Gucer, Patricia W., Engelhardt, Susan M., McDiarmid, Melissa A.

“…A total of 70 military Veterans have been monitored for HPRT T‐cell mutations in five separate studies at 2‐year intervals over an 8‐year period. Systemic…”
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Mutagenicity monitoring following battlefield exposures: Molecular analysis of HPRT mutations in gulf war i veterans exposed to depleted uranium by Nicklas, Janice A., Albertini, Richard J., Vacek, Pamela M., Ardell, Stephanie K., Carter, Elizabeth W., McDiarmid, Melissa A., Engelhardt, Susan M., Gucer, Patricia W., Squibb, Katherine S.

“…Molecular studies that involved cDNA and genomic DNA sequencing as well as multiplex PCR of the HPRT gene were performed to determine the molecular mutational…”
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