Search Results - "McCutcheon, Fiona"

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice by Daglas, Maria, Draxler, Dominik F., Ho, Heidi, McCutcheon, Fiona, Galle, Adam, Au, Amanda E., Larsson, Pia, Gregory, Julia, Alderuccio, Frank, Sashindranath, Maithili, Medcalf, Robert L.

“…Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged immune response in the brain may cause neurodegeneration, resulting…”
Get full text

Plasma from patients with vaccine-induced immune thrombotic thrombocytopenia displays increased fibrinolytic potential and enhances tissue-type plasminogen activator but not urokinase-mediated plasminogen activation by Keragala, Charithani B., McFadyen, James D., Ho, Heidi, McCutcheon, Fiona M., Liu, Zikou, Stevens, Hannah, Monagle, Paul, Chunilal, Sanjeev, Medcalf, Robert L., Tran, Huyen

“…Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare complication of adenovirus vector-based COVID-19 vaccines. VITT is associated with markedly…”
Get full text

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin by Niego, Be'eri, Lee, Natasha, Larsson, Pia, De Silva, T Michael, Au, Amanda E-Ling, McCutcheon, Fiona, Medcalf, Robert L

“…Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced…”
Get full text

Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex by Smart, Caitlin, Mitchell, Anna, McCutcheon, Fiona, Medcalf, Robert L., Thiele, Alexander

“…Tissue-type plasminogen activator (tPA) is a serine protease that is expressed in various compartments in the brain. It is involved in neuronal plasticity,…”
Get full text

Tranexamic acid in a mouse model of cerebral amyloid angiopathy: setting the stage for a novel stroke treatment approach by Liu, Zikou, McCutcheon, Fiona M., Ho, Heidi, Chia, Joanne, Xiao, Yunxin, Tippett, Isabel, Keragala, Charithani B., Cloud, Geoffrey C., Medcalf, Robert L.

“…Symptomatic intracerebral hemorrhage (sICH) commonly occurs in patients with cerebral amyloid angiopathy (CAA). Amyloid also initiates plasminogen activation…”
Get full text

A Coumarin-Based Array for the Discrimination of Amyloids by Trinh, Natalie, Bhuskute, Kaustubh R., Varghese, Nikhil R., Buchanan, Jessica A., Xu, Yijia, McCutcheon, Fiona M., Medcalf, Robert L., Jolliffe, Katrina A., Sunde, Margaret, New, Elizabeth J., Kaur, Amandeep

“…Self-assembly of misfolded proteins can lead to the formation of amyloids, which are implicated in the onset of many pathologies including Alzheimer’s disease…”
Get full text

Tranexamic acid alters the immunophenotype of phagocytes after lower limb surgery by Draxler, Dominik F, Hanafi, Gryselda, Zahra, Saffanah, McCutcheon, Fiona, Ho, Heidi, Keragala, Charithani B, Liu, Zikou, Daly, David, Painter, Thomas, Wallace, Sophia, Plebanski, Magdalena, Myles, Paul S, Medcalf, Robert L

“…Tranexamic acid (TXA) is an antifibrinolytic agent frequently used in elective surgery to reduce blood loss. We recently found it also acts as a potent…”
Get full text

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis by Draxler, Dominik F., Daglas, Maria, Fernando, Anushka, Hanafi, Gryselda, McCutcheon, Fiona, Ho, Heidi, Galle, Adam, Gregory, Julia, Larsson, Pia, Keragala, Charithani, Wright, David K., Tavancheh, Elnaz, Au, Amanda E., Niego, Be'eri, Wilson, Kirsty, Plebanski, Magdalena, Sashindranath, Maithili, Medcalf, Robert L.

Get full text

Selective inhibition of brain endothelial Rhokinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin by Niego, B., Lee, N., Larsson, Pia, de Silva, T. M., Au, A. E. L., McCutcheon, F., Medcalf, R. L.

“…Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced…”
Get full text

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis by Draxler, Dominik F., Daglas, Maria, Fernando, Anushka, Hanafi, Gryselda, McCutcheon, Fiona, Ho, Heidi, Galle, Adam, Gregory, Julia, Larsson, Pia, Keragala, Charithani, Wright, David K., Tavancheh, Elnaz, Au, Amanda E., Niego, Be'eri, Wilson, Kirsty, Plebanski, Magdalena, Sashindranath, Maithili, Medcalf, Robert L.

“…Background Traumatic brain injury (TBI) is known to promote immunosuppression, making patients more susceptible to infection, yet potentially exerting…”
Get full text

011 Ex-vivo generation of plasmin from patients with acute ischaemic stroke is predictive of successful thrombolysis by Levi, Chris, Lillicrap, Thomas, Harman, Stevi, Draxler, Dominik, Niego, Be’Eri, Ho, Heidi, McCutcheon, Fiona, Kleinig, Timothy, Koblar, Simon, Hamilton-Bruce, Monica Anne, Garcia-Esperon, Carlos, Lincz, Lisa, Bivard, Andrew, Attia, John, Maguire, Jane, Holliday, Elizabeth, Medcalf, Robert

“…IntroductionThrombolysis with recombinant tissue-type plasminogen activator (rt-PA) fails in more than 60% of patients with acute ischaemic stroke (AIS)…”
Get full text