Search Results - "McCutcheon, A."

Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms by McCutcheon, Robert A., Abi-Dargham, Anissa, Howes, Oliver D.

“…The mesolimbic hypothesis has been a central dogma of schizophrenia for decades, positing that aberrant functioning of midbrain dopamine projections to limbic…”
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Dopamine and glutamate in schizophrenia: biology, symptoms and treatment by McCutcheon, Robert  A., Krystal, John H., Howes, Oliver D.

“…Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both have been proposed to contribute significantly to the…”
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Sleep and Circadian Rhythm Disturbance in Remitted Schizophrenia and Bipolar Disorder: A Systematic Review and Meta-analysis by Meyer, Nicholas, Faulkner, Sophie M, McCutcheon, Robert A, Pillinger, Toby, Dijk, Derk-Jan, MacCabe, James H

“…Sleep and circadian rhythm disturbances in schizophrenia are common, but incompletely characterized. We aimed to describe and compare the magnitude and…”
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The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis by McCutcheon, Robert A., Pillinger, Toby, Mizuno, Yuya, Montgomery, Adam, Pandian, Haridha, Vano, Luke, Marques, Tiago Reis, Howes, Oliver D.

“…The response to antipsychotic treatment in schizophrenia appears to vary, and as such it has been proposed that different subtypes of schizophrenia exist,…”
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Metastability as a candidate neuromechanistic biomarker of schizophrenia pathology by Hancock, Fran, Rosas, Fernando E, McCutcheon, Robert A, Cabral, Joana, Dipasquale, Ottavia, Turkheimer, Federico E

“…The disconnection hypothesis of schizophrenia proposes that symptoms of the disorder arise as a result of aberrant functional integration between segregated…”
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Altered glutamatergic response and functional connectivity in treatment resistant schizophrenia: the effect of riluzole and therapeutic implications by Pillinger, Toby, Rogdaki, Maria, McCutcheon, Robert A., Hathway, Pamela, Egerton, Alice, Howes, Oliver D.

“…Rationale Anterior cingulate cortex (ACC) glutamatergic abnormalities are reported in treatment-resistant schizophrenia (TRS) and implicated in functional…”
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Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study by McCutcheon, Robert A., Nour, Matthew M., Dahoun, Tarik, Jauhar, Sameer, Pepper, Fiona, Expert, Paul, Veronese, Mattia, Adams, Rick A., Turkheimer, Federico, Mehta, Mitul A., Howes, Oliver D.

“…A wide range of neuropsychiatric disorders, from schizophrenia to drug addiction, involve abnormalities in both the mesolimbic dopamine system and the cortical…”
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The effects of psychosocial stress on dopaminergic function and the acute stress response by Bloomfield, Michael Ap, McCutcheon, Robert A, Kempton, Matthew, Freeman, Tom P, Howes, Oliver

“…Chronic psychosocial adversity induces vulnerability to mental illnesses. Animal studies demonstrate that this may be mediated by dopaminergic dysfunction. We…”
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Incidence and predictors of 30-day readmission for patients discharged home after craniotomy for malignant supratentorial tumors in California (1995-2010) by Marcus, Logan P, McCutcheon, Brandon A, Noorbakhsh, Abraham, Parina, Ralitza P, Gonda, David D, Chen, Clark, Chang, David C, Carter, Bob S

“…Hospital readmission within 30 days of discharge is a major contributor to the high cost of health care in the US and is also a major indicator of patient care…”
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Relationship of A1 segment hypoplasia to anterior communicating artery aneurysm morphology and risk factors for aneurysm formation by Rinaldo, Lorenzo, McCutcheon, Brandon A., Murphy, Meghan E., Bydon, Mohamad, Rabinstein, Alejandro A., Lanzino, Giuseppe

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Predictors of Discharge to a Nonhome Facility in Patients Undergoing Lumbar Decompression Without Fusion for Degenerative Spine Disease by Murphy, Meghan E., Maloney, Patrick R., McCutcheon, Brandon A., Rinaldo, Lorenzo, Shepherd, Daniel, Kerezoudis, Panagiotis, Gilder, Hannah, Ubl, Daniel S., Crowson, Cynthia S., Freedman, Brett A., Habermann, Elizabeth B., Bydon, Mohamad

“…Abstract BACKGROUND Patients recovering from decompressive laminectomy without fusion may require assistance with activities of daily living and…”
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Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study by Howes, Oliver D, Bonoldi, Ilaria, McCutcheon, Robert A, Azis, Matilda, Antoniades, Mathilde, Bossong, Matthijs, Modinos, Gemma, Perez, Jesus, Stone, James M, Santangelo, Barbara, Veronese, Mattia, Grace, Anthony, Allen, Paul, McGuire, Philip K

“…Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies…”
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Glutamate connectivity associations converge upon the salience network in schizophrenia and healthy controls by McCutcheon, Robert A., Pillinger, Toby, Rogdaki, Maria, Bustillo, Juan, Howes, Oliver D.

“…Alterations in cortical inter-areal functional connectivity, and aberrant glutamatergic signalling are implicated in the pathophysiology of schizophrenia but…”
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The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [11C]-(+)-PHNO PET study by Dahoun, Tarik, Nour, Matthew M., McCutcheon, Robert A., Adams, Rick A., Bloomfield, Michael A. P., Howes, Oliver D.

“…Childhood trauma is a risk factor for psychosis. Amphetamine increases synaptic striatal dopamine levels and can induce positive psychotic symptoms in healthy…”
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Inventory of H2O in the ancient Martian regolith from Northwest Africa 7034: The important role of Fe oxides by Muttik, Nele, McCubbin, Francis M., Keller, Lindsay P., Santos, Alison R., McCutcheon, Whitney A., Provencio, Paula P., Rahman, Zia, Shearer, Charles K., Boyce, Jeremy W., Agee, Carl B.

“…Water‐rich Martian regolith breccia Northwest Africa (NWA) 7034 was analyzed by Fourier transform infrared spectroscopy and transmission electron microscopy to…”
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The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment by Jauhar, Sameer, McCutcheon, Robert A., Veronese, Mattia, Borgan, Faith, Nour, Matthew, Rogdaki, Maria, Pepper, Fiona, Stone, James M., Egerton, Alice, Vamvakas, George, Turkheimer, Federico, McGuire, Philip K., Howes, Oliver D.

“…The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists…”
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Lumbar decompression in the elderly: increased age as a risk factor for complications and nonhome discharge by Murphy, Meghan E, Gilder, Hannah, Maloney, Patrick R, McCutcheon, Brandon A, Rinaldo, Lorenzo, Shepherd, Daniel, Kerezoudis, Panagiotis, Ubl, Daniel S, Crowson, Cynthia S, Krauss, William E, Habermann, Elizabeth B, Bydon, Mohamad

“…OBJECTIVE With improving medical therapies for chronic conditions, elderly patients increasingly present as candidates for operative intervention for…”
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Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory by Nour, Matthew M, Dahoun, Tarik, McCutcheon, Robert A, Adams, Rick A, Wall, Matthew B, Howes, Oliver D

“…Working memory performance is thought to depend on both striatal dopamine 2/3 receptors (D2/3Rs) and task-induced functional organisation in key cortical brain…”
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The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: A 1H-MRS study in first-episode psychosis patients by Zahid, Uzma, McCutcheon, Robert A., Borgan, Faith, Jauhar, Sameer, Pepper, Fiona, Nour, Matthew M., Rogdaki, Maria, Osugo, Martin, Murray, Graham K., Hathway, Pamela, Murray, Robin M., Howes, Oliver D.

“…IntroductionGlutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response…”
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The magnitude and variability of neurocognitive performance in first-episode psychosis: a systematic review and meta-analysis of longitudinal studies by Catalan, Ana, McCutcheon, Robert A., Aymerich, Claudia, Pedruzo, Borja, Radua, Joaquim, Rodríguez, Victoria, Salazar de Pablo, Gonzalo, Pacho, Malein, Pérez, Jose Luis, Solmi, Marco, McGuire, Philip, Giuliano, Anthony J., Stone, William S., Murray, Robin M., Gonzalez-Torres, Miguel Angel, Fusar-Poli, Paolo

“…Neurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether they affect all individuals uniformly. The aim of this systematic…”
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