Search Results - "McCuskey, Robert"

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent by Gan, Lay T, Van Rooyen, Derrick M, Koina, Mark E, McCuskey, Robert S, Teoh, Narcissus C, Farrell, Geoffrey C

“…Background & Aims Free cholesterol (FC) accumulates in non-alcoholic steatohepatitis (NASH) but not in simple steatosis. We sought to establish how FC causes…”
Get full text

The Hepatic Microvascular System in Health and Its Response to Toxicants by Mccuskey, Robert S.

“…This review briefly summarizes what is known about the dynamic morphology of the hepatic microvascular system that includes all vessels in the liver with a…”
Get full text

Prevention of Hepatic Fibrosis in a Murine Model of Metabolic Syndrome with Nonalcoholic Steatohepatitis by DeLeve, Laurie D, Wang, Xiangdong, Kanel, Gary C, Atkinson, Roscoe D, McCuskey, Robert S

“…The endocannabinoid pathway plays an important role in the regulation of appetite and body weight, hepatic lipid metabolism, and fibrosis. Blockade of the…”
Get full text

Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation by DeLeve, Laurie D, Wang, Xiangdong, Hu, Liping, McCuskey, Margaret K, McCuskey, Robert S

“…The phenotypic features of liver sinusoidal endothelial cells (SEC), open fenestrae in sieve plates and lack of a basement membrane, are lost with…”
Get more information

Acute atorvastatin is hepatoprotective against ischaemia-reperfusion injury in mice by modulating eNOS and microparticle formation by Ajamieh, Hussam, Farrell, Geoffrey C., McCuskey, Robert S., Yu, Jun, Chu, Eagle, Wong, Heng-Jian, Lam, Wesley, Teoh, Narci C.

“…Background & Aims Steatosis accentuates the severity of hepatic ischaemia‐reperfusion injury (IRI); ‘statins’ (HMG‐CoA reductase inhibitors) protect the heart…”
Get full text

Old Age and the Hepatic Sinusoid by Le Couteur, David G., Warren, Alessandra, Cogger, Victoria C., Smedsrød, Bård, Sørensen, Karen K., De Cabo, Rafael, Fraser, Robin, Mccuskey, Robert S.

“…Morphological changes in the hepatic sinusoid with old age are increasingly recognized. These include thickening and defenestration of the liver sinusoidal…”
Get full text

Hepatic disposal of advanced glycation end products during maturation and aging by Svistounov, Dmitri, Oteiza, Ana, Zykova, Svetlana N., Sørensen, Karen Kristine, McCourt, Peter, McLachlan, Andrew J., McCuskey, Robert S., Smedsrød, Bård

“…Aging is characterized by progressive loss of metabolic and biochemical functions and accumulation of metabolic by-products, including advanced glycation end…”
Get full text

Liver Sinusoidal Endothelial Cells by Sørensen, Karen Kristine, Simon-Santamaria, Jaione, McCuskey, Robert S, Smedsrød, Bård

“…The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic sinusoid and functions as a control post regulating and surveying the…”
Get more information

Age-related changes in the hepatic microcirculation in mice by Ito, Yoshiya, Sørensen, Karen K., Bethea, Nancy W., Svistounov, Dmitri, McCuskey, Margaret K., Smedsrød, Bård H., McCuskey, Robert S.

“…Aging of the liver is associated with impaired metabolism of drugs, adverse drug interactions, and susceptibility to toxins. Since reduced hepatic blood flow…”
Get full text

Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice by McCuskey, Robert S., Ito, Yoshiya, Robertson, Graham R., McCuskey, Margaret K., Perry, Michael, Farrell, Geoffrey C.

“…In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance for hepatocellular function, perisinusoidal fibrosis, and portal…”
Get full text

Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice by Hasegawa, Tadashi, Ito, Yoshiya, Wijeweera, Jayanthika, Liu, Jie, Malle, Ernst, Farhood, Anwar, McCuskey, Robert S, Jaeschke, Hartmut

“…Steatosis is a major risk factor for complications after liver surgery. Since neutrophil cytotoxicity is critical for ischemia-reperfusion injury in normal…”
Get more information

Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates by DeLeve, Laurie D, Wang, Xiangdong, McCuskey, Margaret K, McCuskey, Robert S

“…The gold standard for the identification of sinusoidal endothelial cells (SEC) is the presence of fenestrae organized in sieve plates, which is characteristic…”
Get more information

Portosystemic Shunting and Persistent Fetal Vascular Structures in Aryl hydrocarbon Receptor-Deficient Mice by Lahvis, Garet P., Lindell, Susanne L., Thomas, Russell S., McCuskey, Robert S., Murphy, Christopher, Glover, Edward, Bentz, Michael, Southard, James, Bradfield, Christopher A.

“…A physiological examination of mice harboring a null allele at the aryl hydrocarbon (Ah) locus revealed that the encoded aryl hydrocarbon receptor plays a role…”
Get full text

Effects of oxidized low-density lipoproteins on the hepatic microvasculature by Oteiza, Ana, Li, Ruomei, McCuskey, Robert S, Smedsrød, Bård, Sørensen, Karen Kristine

“…Oxidized low-density lipoproteins (oxLDLs) are involved in proinflammatory and cytotoxic events in different microcirculatory systems. The liver is an…”
Get more information

Short-term therapy with peroxisome proliferation-activator receptor-[alpha] agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury by Teoh, Narci C, Williams, Jacqueline, Hartley, Jennifer, Yu, Jun, McCuskey, Robert S, Farrell, Geoffrey C

“…Steatosis increases operative morbidity/mortality from ischemia-reperfusion injury (IRI); few pharmacological approaches have been protective. Using novel…”
Get full text

Sinusoidal endothelial cells as an early target for hepatic toxicants by McCuskey, Robert S

“…Recent studies demonstrate that the hepatic sinusoidal endothelial cells (SEC) are a sensitive direct target for early toxicity to acetaminophen (paracetamol,…”
Get more information

Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model by Dvorak, Bohuslav, Halpern, Melissa D, Holubec, Hana, Williams, Catherine S, McWilliam, Debra L, Dominguez, Jessica A, Stepankova, Renata, Payne, Claire M, McCuskey, Robert S

“…Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease of prematurely born infants. Maternal milk plays an important protective role…”
Get more information

Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome by DeLeve, Laurie D, Ito, Yoshiya, Bethea, Nancy W, McCuskey, Margaret K, Wang, Xiangdong, McCuskey, Robert S

“…Mechanisms leading to the obstruction of the microcirculation in sinusoidal obstruction syndrome (SOS) have been unclear. Because this occurs at the onset of…”
Get more information

The importance of anatomy in health professions education and the shortage of qualified educators by McCuskey, Robert S, Carmichael, Stephen W, Kirch, Darrell G

“…The current shortage of faculty qualified to teach anatomy in U.S. medical schools is reversible. Sufficient numbers of individuals are in the pipeline to…”
Get full text

Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver by Joseph, Brigid, Malhi, Harmeet, Bhargava, Kuldeep K., Palestro, Christopher J., McCuskey, Robert S., Gupta, Sanjeev

“…Background & Aims: Kupffer cells are activated shortly after deposition of hepatocytes in liver sinusoids, with clearance of a significant fraction of…”
Get full text