Search Results - "McCuskey, Margaret K."

Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation by DeLeve, Laurie D, Wang, Xiangdong, Hu, Liping, McCuskey, Margaret K, McCuskey, Robert S

“…The phenotypic features of liver sinusoidal endothelial cells (SEC), open fenestrae in sieve plates and lack of a basement membrane, are lost with…”
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Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates by DeLeve, Laurie D, Wang, Xiangdong, McCuskey, Margaret K, McCuskey, Robert S

“…The gold standard for the identification of sinusoidal endothelial cells (SEC) is the presence of fenestrae organized in sieve plates, which is characteristic…”
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Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome by DeLeve, Laurie D, Ito, Yoshiya, Bethea, Nancy W, McCuskey, Margaret K, Wang, Xiangdong, McCuskey, Robert S

“…Mechanisms leading to the obstruction of the microcirculation in sinusoidal obstruction syndrome (SOS) have been unclear. Because this occurs at the onset of…”
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Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen by McCuskey, Robert S., Bethea, Nancy W., Wong, Jennifer, McCuskey, Margaret K., Abril, Edward R., Wang, Xiangdong, Ito, Yoshiya, DeLeve, Laurie D.

“…The pathophysiology of binge drinking of ethanol and its potentiation of acetaminophen (APAP) toxicity has received very little attention. To evaluate if…”
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Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide by Mayer, Loretta P, Pearsall, Nicole A, Christian, Patricia J, Devine, Patrick J, Payne, Claire M, McCuskey, Margaret K, Marion, Samuel L, Sipes, I.Glenn, Hoyer, Patricia B

“…4-Vinylcyclohexene diepoxide (VCD) destroys preantral ovarian follicles in rats. Female 28-day Fisher 344 (F344) rats were dosed (30 days) with VCD (80 mg/kg…”
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Dietary Steatotic Liver Attenuates Acetaminophen Hepatotoxicity in Mice by ITO, YOSHIYA, ABRIL, EDWARD R., BETHEA, NANCY W., MCCUSKEY, MARGARET K., MCCUSKEY, ROBERT S.

“…Objective: To determine whether hepatic steatosis is susceptible to acetaminophen (APAP) hepatotoxicity. Methods: Male C57Bl/6 mice were fed a "Western-style"…”
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Age-related changes in the hepatic microcirculation in mice by Ito, Yoshiya, Sørensen, Karen K., Bethea, Nancy W., Svistounov, Dmitri, McCuskey, Margaret K., Smedsrød, Bård H., McCuskey, Robert S.

“…Aging of the liver is associated with impaired metabolism of drugs, adverse drug interactions, and susceptibility to toxins. Since reduced hepatic blood flow…”
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Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice by McCuskey, Robert S., Ito, Yoshiya, Robertson, Graham R., McCuskey, Margaret K., Perry, Michael, Farrell, Geoffrey C.

“…In alcoholic steatohepatitis, hepatic microvascular changes have pathogenic significance for hepatocellular function, perisinusoidal fibrosis, and portal…”
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Diannexin, a Novel Annexin V Homodimer, Provides Prolonged Protection Against Hepatic Ischemia-Reperfusion Injury in Mice by Teoh, Narci C, Ito, Yoshiya, Field, Jacqueline, Bethea, Nancy W, Amr, Deama, McCuskey, Margaret K, McCuskey, Robert S, Farrell, Geoffrey C, Allison, Anthony C

“…Background & Aims: Ischemia-reperfusion injury (IRI) remains an important cause of liver failure after hepatic surgery or transplantation. The mechanism seems…”
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Hepatic Microcirculatory Dysfunction During Cholestatic Liver Injury in Rats by ITO, YOSHIYA, BETHEA, NANCY W., BAKER, GREGORY L., MCCUSKEY, MARGARET K., URBASCHEK, RENATE, MCCUSKEY, ROBERT S.

“…ABSTRACT Objective: The present study was conducted to elucidate the sequential alterations in the hepatic microvascular inflammatory response to extrahepatic…”
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Characterization of a reproducible rat model of hepatic veno‐occlusive disease by DeLeve, Laurie D., McCuskey, Robert S., Wang, Xiangdong, Hu, Liping, McCuskey, Margaret K., Epstein, Robert B., Kanel, Gary C.

“…Lack of a reproducible animal model has hampered progress in understanding hepatic veno‐occlusive disease (HVOD). This article characterizes a reproducible…”
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Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice by Ito, Yoshiya, Abril, Edward R, Bethea, Nancy W, McCuskey, Margaret K, Cover, Cathleen, Jaeschke, Hartmut, McCuskey, Robert S

“…Neutrophil extravasation from sinusoids is a critical step for acute inflammatory tissue injury. However, the role of sinusoidal endothelial cells (SECs) in…”
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A bile acid-induced apoptosis assay for colon cancer risk and associated quality control studies by BERNSTEIN, C, BERNSTEIN, H, PAYNE, C, GAREWAL, H, DINNING, P, JABI, R, SAMPLINER, R. E, MCCUSKEY, M. K, PANDA, M, ROE, D. J, L'HEUREUX, L

“…Bile acids are important in the etiology of colorectal cancer. Bile acids induce apoptosis in colonic goblet cells at concentrations comparable to those found…”
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Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome by Deleve, Laurie D., Wang, Xiangdong, Kanel, Gary C., Ito, Yoshiya, Bethea, Nancy W., McCuskey, Margaret K., Tokes, Zoltan A., Tsai, Jeffrey, McCuskey, Robert S.

“…This study examined the role of decreased nitric oxide (NO) in the microcirculatory obstruction of hepatic sinusoidal obstruction syndrome (SOS). SOS was…”
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In vivo and electron microscopic observations of the responses of the hepatic sinusoid to interleukin-1 by Nishida, J, McDonnell, D, McCuskey, M K, Ekataksin, W, McCuskey, R S

“…Interleukin-1 (IL-1), which is produced by Kupffer cells and sinusoidal endothelial cells, may play an important role in immunological and microvascular…”
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Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome by DeLeve, Laurie D., Wang, Xiangdong, Kanel, Gary C., Ito, Yoshiya, Bethea, Nancy W., McCuskey, Margaret K., Tokes, Zoltan A., Tsai, Jeffrey, McCuskey, Robert S.

“…This study examined the role of decreased nitric oxide (NO) in the microcirculatory obstruction of hepatic sinusoidal obstruction syndrome (SOS). SOS was…”
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Hepatic microvascular development in relation to the morphogenesis of hepatocellular plates in neonatal rats by McCuskey, Robert S., Ekataksin, Wichai, LeBouton, Albert V., Nishida, Jiro, McCuskey, Margaret K., McDonnell, Deboragh, Williams, Catherine, Bethea, Nancy W., Dvorak, Bohuslav, Koldovsky, Otakar

“…The development of hepatic microvascular heterogeneity after birth, and its temporal relationship to the development of parenchymal cell plates have received…”
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1023 Paracrine and autocrine regulation of rat sinusoidal endothelial cell phenotype by DeLeve, Laurie D., Wang, Xiangdong, Hu, Liping, McCuskey, Margaret K., McCuskey, Robert S.

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Hepatic Microcirculatory Dysfunction During Cholestatic Liver Injury in Rats by ITO, YOSHIYA, BETHEA, NANCY W., BAKER, GREGORY L., MCCUSKEY, MARGARET K., URBASCHEK, RENATE, MCCUSKEY, ROBERT S.

“…Objective:The present study was conducted to elucidate the sequential alterations in the hepatic microvascular inflammatory response to extrahepatic biliary…”
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Embolization by sinusoidal lining cells causes the congestion of hepatic venoocclusive disease by DeLeve, Laurie D., Ito, Yoshiya, Machen, Nancy W., McCuskey, Margaret K., Wang, Xiangdong, McCuskey, Robert S.

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