Search Results - "McCune, S A"

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure by Gómez, A. M., Valdivia, H. H., Cheng, H., Lederer, Miriam R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., Lederer, W. J.

“…Cardiac hypertrophy and heart failure caused by high blood pressure were studied in single myocytes taken from hypertensive rats (Dahl SS/Jr) and SH-HF rats in…”
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Fatty acid oxidation enzyme gene expression is downregulated in the failing heart by SACK, M. N, RADER, T. A, PARK, S, BASTIN, J, MCCUNE, S. A, KELLY, D. P

“…During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to glucose. This metabolic switch, which…”
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AIN‐76A defined rodent diet accelerates the development of heart failure in SHHF rats: A cautionary note on its use in cardiac studies by Rees, M. L, Gioscia‐Ryan, R. A, McCune, S. A, Browder, J. C, Zachman, D. K, Chicco, A. J, Johnson, C. A, Murphy, R. C, Moore, R. L, Sparagna, G. C

“…Previous studies from our laboratory have shown positive benefits of linoleic acid (LA) feeding for attenuation of rat heart failure (HF). However, another…”
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Maladaptive Remodeling of Cardiac Myocyte Shape Begins Long Before Failure in Hypertension by Onodera, Tatsuyuki, Tamura, Tetsutaro, Said, Suleman, McCune, Sylvia A, Gerdes, A. Martin

“…Progression to failure in hypertension is associated with ventricular dilation, excessive myocyte lengthening, and an increase in myocyte length/width ratio…”
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Myocyte Remodeling During the Progression to Failure in Rats With Hypertension by Gerdes, A. Martin, Onodera, Tatsuyuki, Wang, Xuejun, McCune, Sylvia A

“…Regional changes in cardiac myocyte shape during the progression to failure with hypertension have not been clearly established. To address this issue, we…”
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Echocardiographic characterization of left ventricular adaptation in a genetically determined heart failure rat model by Haas, Garrie J., McCune, Sylvia A., Brown, Douglas M., Cody, Robert J.

“…This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure—prone rat strain designated…”
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Exercise training down-regulates ob gene expression in the genetically obese SHHF/Mcc-fa(cp) rat by Friedman, J E, Ferrara, C M, Aulak, K S, Hatzoglou, M, McCune, S A, Park, S, Sherman, W M

“…The recently cloned obesity gene (ob) encodes a protein, leptin, which is secreted from adipose tissue and interacts with hypothalamic receptors to decrease…”
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Effects of obesity and hypertension on ventricular myocytes: comparison of cells from adult SHHF/Mcc-cp and JCR:LA-cp rats by Hohl, C M, Hu, B, Fertel, R H, Russell, J C, McCune, S A, Altschuld, R A

“…The aim was to compare beta adrenergic receptors, cAMP production, and Ca2+ accumulation by the sarcoplasmic reticulum in ventricular cardiomyocytes from…”
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Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats by Holycross, B J, Summers, B M, Dunn, R B, McCune, S A

“…Plasma renin activity (PRA) increases during heart failure; however, PRA is altered by drug therapy, and it is difficult to study the natural progression of…”
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Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus by Chiasera, J M, Ward-Cook, K M, McCune, S A, Wardlaw, G M

“…The effect of aerobic exercise intervention on the renal functional and ultrastructural changes associated with diabetes mellitus were studied in the obese…”
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Obese female SHHF/Mcc-fa(cp) rats resist antihypertensive effects of renin-angiotensin system inhibition by Sharkey, L C, Holycross, B J, McCune, S A, Radin, M J

“…Gender and obesity may influence response to pharmacological modulation of the renin-angiotensin system. We used SHHF/Mcc-fa(cp) rats to study effect of…”
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Effects of acute running exercise on whole body insulin action in obese male SHHF/Mcc-facp rats by Gao, J, Sherman, W M, McCune, S A, Osei, K

“…This study utilized the obese male spontaneously hypertensive heart failure rat (SHHF/Mcc-facp), which has metabolic features very similar to human…”
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Aurintricarboxylic acid is a potent inhibitor of phosphofructokinase by McCune, S A, Foe, L G, Kemp, R G, Jurin, R R

“…Aurintricarboxylic acid (ATA) was found to be a very potent inhibitor of purified rabbit liver phosphofructokinase (PFK), giving 50% inhibition at 0.2 microM…”
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Short-term hormonal control of hepatic lipogenesis by Geelen, M J, Harris, R A, Beynen, A C, McCune, S A

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Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesis by McCune, S A, Harris, R A

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Synergistic effects of male sex and obesity on hepatic insulin dynamics in SHR/Mcc-cp rat by Hennes, M. M., McCune, S. A., Shrago, E., Kissebah, A. H.

“…Synergistic effects of male sex and obesity on hepatic insulin dynamics in SHR/Mcc-cp rat. M M Hennes , S A McCune , E Shrago and A H Kissebah Department of…”
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Spontaneous pregnancy-induced hypertension and intrauterine growth restriction in rats by Sharkey, Leslie C, McCune, Sylvia A, Yuan, Olive, Lange, Craig, Fray, John

“…The SHHF/Mcc- fa cp (spontaneous hypertension and heart failure) rat is advanced as a novel and suitable non-primate model of pregnancy-associated hypertension…”
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Mitochondrial storage forms of acetyl CoA carboxylase: mobilization/activation accounts for increased activity of the enzyme in liver of genetically obese Zucker rats by Allred, J B, Roman-Lopez, C R, Jurin, R R, McCune, S A

“…In earlier reports, we have described a previously unrecognized mechanism which regulates the activity of acetyl CoA carboxylase in rat liver by the control of…”
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Hereditary pituitary prolactinomas: a new rat model by Chedid, A, Hoversland, R C, Chejfec, G, McCune, S A, Jurin, R R, Evans, E E

“…Pituitary adenomas are known to occur spontaneously in several rat strains, especially during aging. Here we report the occurrence of adenomas (prolactinomas)…”
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Myocardial tumor necrosis factor-alpha secretion in hypertensive and heart failure-prone rats by Bergman, M R, Kao, R H, McCune, S A, Holycross, B J

“…Acute increases in blood pressure (BP) increase myocardial tumor necrosis factor (TNF)-alpha production, but it is not known whether chronic hypertensive…”
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