Search Results - "McCully, C L"

Effect of body position on ventricular CSF methotrexate concentration following intralumbar administration by Blaney, S M, Poplack, D G, Godwin, K, McCully, C L, Murphy, R, Balis, F M

“…Intralumbar methotrexate is one of the primary therapeutic modalities for the prevention and treatment of meningeal leukemia. However, methotrexate…”
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Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration by BALIS, F. M, BLANEY, S. M, MCCULLY, C. L, BACHER, J. D, MURPHY, R. F, POPLACK, D. G

“…Intrathecal methotrexate achieves high concentrations in cerebrospinal fluid (CSF), but drug distribution throughout the subarachnoid space after an…”
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Fluconazole Penetration into Cerebrospinal Fluid: Implications for Treating Fungal Infections of the Central Nervous System by Arndt, Carola A. S., Walsh, Thomas J., McCully, Cynthia Lester, Balis, Frank M., Pizzo, Philip A., Poplack, David G.

“…Fluconazole is a new triazole antifungal agent that has unique pharmacokinetic and pharmacological properties. The bioavailability after oral administration in…”
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Pharmacokinetics of O6-benzylguanine and its active metabolite 8-oxo-O6-benzylguanine in plasma and cerebrospinal fluid after intrathecal administration of O6-benzylguanine in the nonhuman primate by BERG, S. L, MURRY, D. J, MCCULLY, C. L, GODWIN, K, BALIS, F. M

“…O6-Benzylguanine (O6BG) irreversibly inactivates the single-turnover DNA repair protein alkylguanine-alkyltransferase. Thus, O6BG increases tumor-cell…”
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Pyrimidine dideoxyribonucleosides: selectivity of penetration into cerebrospinal fluid by Collins, J M, Klecker, Jr, R W, Kelley, J A, Roth, J S, McCully, C L, Balis, F M, Poplack, D G

“…Cerebrospinal fluid (CSF)/plasma ratios of 1 to 30% were obtained in rhesus monkeys for the 3'-azido- and 2',3'-dideoxy-analogs of thymidine, deoxycytidine and…”
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Methotrexate pharmacokinetics following administration of recombinant carboxypeptidase-G2 in rhesus monkeys by Adamson, P C, Balis, F M, McCully, C L, Godwin, K S, Poplack, D G

“…Carboxypeptidase-G2 (CPDG2) is a bacterial enzyme that rapidly hydrolyzes methotrexate (MTX) into inactive metabolites. As an alternative form of rescue after…”
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Rescue of experimental intrathecal methotrexate overdose with carboxypeptidase-G2 by Adamson, P C, Balis, F M, McCully, C L, Godwin, K S, Bacher, J D, Walsh, T J, Poplack, D G

“…The carboxypeptidase G class of enzymes rapidly hydrolyze methotrexate (MTX) into the inactive metabolites 4-deoxy-4-amino-N10-methylpteroic acid (DAMPA) and…”
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Pharmacokinetics of the Protease Inhibitor KNI-272 in Plasma and Cerebrospinal Fluid in Nonhuman Primates after Intravenous Dosing and in Human Immunodeficiency Virus-Infected Children after Intravenous and Oral Dosing by MUELLER, B. U, ANDERSON, B. D, BALIS, F. M, FARLEY, M. Q, MURPHY, R, ZUCKERMAN, J, JAROSINSKI, P, GODWIN, K, MCCULLY, C. L, MITSUYA, H, PIZZO, P. A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacokinetics of PEG-L-asparaginase and plasma and cerebrospinal fluid L-asparagine concentrations in the rhesus monkey by BERG, S. L, BALIS, F. M, MCCULLY, C. L, GODWIN, K. S, POPLACK, D. G

“…The pharmacokinetics of the polyethylene glycol-conjugated form of the enzyme L-asparaginase and the depletion of L-asparagine from the plasma and…”
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Pharmacokinetics of pyrazoloacridine in the rhesus monkey by BERG, S. L, BALIS, F. M, MCCULLY, C. L, GODWIN, K. S, POPLACK, D. G

“…Pyrazoloacridine is a rationally synthesized acridine derivative with in vitro activity against solid tumor cell lines, noncycling and hypoxic cells, and tumor…”
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Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates by FOX, Elizabeth, MURPHY, Robert F, MCCULLY, Cynthia L, ADAMSON, Peter C

“…Hypericin, a polycyclic aromatic dianthroquinone, is a natural pigment derived from the plant Hypericum perforatum (St John's Wort). The compound has been…”
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Cerebrospinal fluid penetration of active metabolites of cyclophosphamide and ifosfamide in rhesus monkeys by ARNDT, C. A. S, BALIS, F. M, MCCULLY, C. L, COLVIN, O. M, POPLACK, D. G

“…The penetration of the active metabolites of cyclophosphamide (CP) and ifosfamide (IF) into cerebrospinal fluid (CSF) was determined in rhesus monkeys…”
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Bioavailability of low-dose vs high-dose 6-mercaptopurine by Arndt, C A, Balis, F M, McCully, C L, Jeffries, S L, Doherty, K, Murphy, R, Poplack, D G

“…The bioavailability of oral 6-mercaptopurine (6MP) at standard doses is very low, largely as a result of extensive first-pass metabolism by xanthine oxidase…”
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Intrathecal 5-fluorouracil in the rhesus monkey by BERG, S. L, BALIS, F. M, MCCULLY, C. L, PARKER, G. A, MURPHY, R. F, POPLACK, D. G

“…Because meningeal spread of both leukemia and solid tumors remains a difficult therapeutic problem, there is a compelling need to develop new agents for…”
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A rhesus monkey model for continuous infusion of drugs into cerebrospinal fluid by McCully, C L, Balis, F M, Bacher, J, Phillips, J, Poplack, D G

“…A new rhesus monkey model with two intraventricular catheter systems was developed to examine the pharmacokinetics and neurotoxicity of chemotherapeutic agents…”
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Re: Toxicity of intrathecal melphalan by Berg, S, Balis, F M, McCully, C L, Poplack, D C

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Cerebral subarachnoid sampling of cerebrospinal fluid in the rhesus monkey by Bacher, J D, Balis, F M, McCully, C L, Godwin, K S

“…A previously described rhesus monkey model with two intraventricular catheter systems was expanded to provide a means of studying drug concentrations of…”
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Plasma and Cerebrospinal Fluid Pharmacokinetics of O6-Benzylguanine and Analogues in Nonhuman Primates by LONG, Lina, BERG, Stacey L, ROY, Sandip K, MCCULLY, Cindy L, SONG-YOO, Hee-Won, MOSCHEL, Robert C, BALIS, Frank M, DOLAN, M. Eileen

“…O 6 -Benzylguanine (BG) is a potent, specific inactivator of the DNA repair protein, O 6 -alkylguanine-DNA alkyltransferase, that enhances the sensitivity of…”
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Zidovudine concentration in brain extracellular fluid measured by microdialysis: steady-state and transient results in rhesus monkey by Fox, Elizabeth, Bungay, Peter M, Bacher, John, McCully, Cynthia L, Dedrick, Robert L, Balis, Frank M

“…We measured zidovudine concentrations in blood, muscle, and brain extracellular fluid (ECF) by microdialysis and in serum ultrafiltrate and cerebrospinal fluid…”
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Incorporation of an enrichment program into a study protocol involving long-term restraint in macaques by McGuffey, Leticia H, McCully, Cynthia L, Bernacky, Bruce J, Blaney, Susan M

“…Nonhuman primates might experience stress during periods of restraint associated with research procedures. In an attempt to minimize such stress, the authors…”
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