Search Results - "McCulloch, M.C."

Genetic background determines phenotypic severity of the Plp rumpshaker mutation by Al-Saktawi, K., McLaughlin, M., Klugmann, M., Schneider, A., Barrie, J.A., McCulloch, M.C., Montague, P., Kirkham, D., Nave, K.-A., Griffiths, I.R.

“…The rumpshaker mutation of the proteolipid protein (Plp) gene causes dysmyelination in man and mouse. We show that the phenotype in the mouse depends…”
Get full text

Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene by Anderson, T.J., Schneider, A., Barrie, J.A., Klugmann, M., McCulloch, M.C., Kirkham, D., Kyriakides, E., Nave, K.-A., Griffiths, I.R.

“…Mutations of the proteolipid protein (Plp) gene cause a generalized central nervous system (CNS) myelin deficit in Pelizaeus‐Merzbacher disease of man and…”
Get full text

Myelin proteolipid proteins promote the interaction of oligodendrocytes and axons by Yool, D.A., Klugmann, M., McLaughlin, M., Vouyiouklis, D.A., Dimou, L., Barrie, J.A., McCulloch, M.C., Nave, K.-A., Griffiths, I.R.

“…Although proteolipid protein (PLP) and its DM20 isoform are the major membrane proteins of CNS myelin, their absence causes surprisingly few developmental…”
Get full text

Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform by Yool, D., Montague, P., McLaughlin, M., McCulloch, M.C., Edgar, J.M., Nave, K.-A., Davies, R.W., Griffiths, I.R., McCallion, A.S.

“…Myelin‐associated oligodendrocytic basic protein (MOBP) is a recently identified major component of central nervous system (CNS) myelin. We previously reported…”
Get full text

Survival of, and Competition between, Oligodendrocytes Expressing Different Alleles of the Plp Gene by Edgar, J. M., Anderson, T. J., Dickinson, P. J., Barrie, J. A., McCulloch, M. C., K.-A. Nave, Griffiths, I. R.

“…Mutations in the X-linked Plp gene lead to dysmyelinating phenotypes and oligodendrocyte cell death. Here, we exploit the X inactivation phenomenon to show…”
Get full text

Nerve fibres in spinal cord impact injuries. Part 1. Changes in the myelin sheath during the initial 5 weeks by Griffiths, I R, McCulloch, M C

“…The spinal cords of cats were subjected to an impact injury using a "weight dropping" technique and sequential changes in the sheaths of non-degenerate…”
Get more information