Search Results - "McCulloch, A."

Mechanical regulation of myofibroblast phenoconversion and collagen contraction by Hinz, Boris, McCulloch, Christopher A., Coelho, Nuno M.

“…Activated fibroblasts promote physiological wound repair following tissue injury. However, dysregulation of fibroblast activation contributes to the…”
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Reinventing the wheel? Reassessing the roles of gene flow, sorting and convergence in repeated evolution by Waters, Jonathan M., McCulloch, Graham A.

“…Biologists have long been intrigued by apparently predictable and repetitive evolutionary trajectories inferred across a variety of lineages and systems. In…”
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Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix by Pakshir, Pardis, Alizadehgiashi, Moien, Wong, Boaz, Coelho, Nuno Miranda, Chen, Xingyu, Gong, Ze, Shenoy, Vivek B., McCulloch, Christopher A., Hinz, Boris

“…Macrophage (Mϕ)-fibroblast interactions coordinate tissue repair after injury whereas miscommunications can result in pathological healing and fibrosis. We…”
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Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance by Rosshart, Stephan P., Vassallo, Brian G., Angeletti, Davide, Hutchinson, Diane S., Morgan, Andrew P., Takeda, Kazuyo, Hickman, Heather D., McCulloch, John A., Badger, Jonathan H., Ajami, Nadim J., Trinchieri, Giorgio, Pardo-Manuel de Villena, Fernando, Yewdell, Jonathan W., Rehermann, Barbara

“…Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living…”
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Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients by Davar, Diwakar, Dzutsev, Amiran K, McCulloch, John A, Rodrigues, Richard R, Chauvin, Joe-Marc, Morrison, Robert M, Deblasio, Richelle N, Menna, Carmine, Ding, Quanquan, Pagliano, Ornella, Zidi, Bochra, Zhang, Shuowen, Badger, Jonathan H, Vetizou, Marie, Cole, Alicia M, Fernandes, Miriam R, Prescott, Stephanie, Costa, Raquel G F, Balaji, Ascharya K, Morgun, Andrey, Vujkovic-Cvijin, Ivan, Wang, Hong, Borhani, Amir A, Schwartz, Marc B, Dubner, Howard M, Ernst, Scarlett J, Rose, Amy, Najjar, Yana G, Belkaid, Yasmine, Kirkwood, John M, Trinchieri, Giorgio, Zarour, Hassane M

“…Anti-programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut…”
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Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells by Ma, Chi, Han, Miaojun, Heinrich, Bernd, Fu, Qiong, Zhang, Qianfei, Sandhu, Milan, Agdashian, David, Terabe, Masaki, Berzofsky, Jay A, Fako, Valerie, Ritz, Thomas, Longerich, Thomas, Theriot, Casey M, McCulloch, John A, Roy, Soumen, Yuan, Wuxing, Thovarai, Vishal, Sen, Shurjo K, Ruchirawat, Mathuros, Korangy, Firouzeh, Wang, Xin Wei, Trinchieri, Giorgio, Greten, Tim F

“…Primary liver tumors and liver metastasis currently represent the leading cause of cancer-related death. Commensal bacteria are important regulators of…”
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Contribution of collagen adhesion receptors to tissue fibrosis by Coelho, Nuno Miranda, McCulloch, Christopher A.

“…Fibrosis is the result of a wound-healing response that fails to restore normal tissue structure function. One of the critical hallmarks of fibrosis is…”
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Laboratory mice born to wild mice have natural microbiota and model human immune responses by Rosshart, Stephan P, Herz, Jasmin, Vassallo, Brian G, Hunter, Ashli, Wall, Morgan K, Badger, Jonathan H, McCulloch, John A, Anastasakis, Dimitrios G, Sarshad, Aishe A, Leonardi, Irina, Collins, Nicholas, Blatter, Joshua A, Han, Seong-Ji, Tamoutounour, Samira, Potapova, Svetlana, Foster St Claire, Mark B, Yuan, Wuxing, Sen, Shurjo K, Dreier, Matthew S, Hild, Benedikt, Hafner, Markus, Wang, David, Iliev, Iliyan D, Belkaid, Yasmine, Trinchieri, Giorgio, Rehermann, Barbara

“…Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by…”
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Infection trains the host for microbiota-enhanced resistance to pathogens by Stacy, Apollo, Andrade-Oliveira, Vinicius, McCulloch, John A., Hild, Benedikt, Oh, Ji Hoon, Perez-Chaparro, P. Juliana, Sim, Choon K., Lim, Ai Ing, Link, Verena M., Enamorado, Michel, Trinchieri, Giorgio, Segre, Julia A., Rehermann, Barbara, Belkaid, Yasmine

“…The microbiota shields the host against infections in a process known as colonization resistance. How infections themselves shape this fundamental process…”
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Role of Fibroblast Populations in Periodontal Wound Healing and Tissue Remodeling by Smith, Patricio C, Martínez, Constanza, Martínez, Jorge, McCulloch, Christopher A

“…After injury to periodontal tissues, a sequentially phased healing response is initiated that enables wound closure and partial restoration of tissue structure…”
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Cell mechanics: integrating cell responses to mechanical stimuli by Janmey, Paul A, McCulloch, Christopher A

“…Forces are increasingly recognized as major regulators of cell structure and function, and the mechanical properties of cells are essential to the mechanisms…”
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The Neutrophil: Constant Defender and First Responder by Fine, Noah, Tasevski, Nikola, McCulloch, Christopher A, Tenenbaum, Howard C, Glogauer, Michael

“…The role of polymorphonuclear neutrophils (PMNs) in biology is often recognized during pathogenesis associated with PMN hyper- or hypo-functionality in various…”
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Phylogenetic divergence of island biotas: Molecular dates, extinction, and “relict” lineages by McCulloch, Graham A., Waters, Jonathan M.

“…Island formation is a key driver of biological evolution, and several studies have used geological ages of islands to calibrate rates of DNA change. However,…”
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Herbivores drive scarcity of some nitrogen-fixing tropical trees by Winbourne, Joy B., McCulloch, Lindsay A.

“…In mature tropical forests, trees that can capture nitrogen experience high levels of herbivory. This could explain the low abundance of such trees, and…”
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Multifunctional roles of gelsolin in health and diseases by Li, Guo Hua, Arora, Pamela D., Chen, Yu, McCulloch, Christopher A., Liu, Peter

“…Gelsolin, a Ca2+‐regulated actin filament severing, capping, and nucleating protein, is an ubiquitous, multifunctional regulator of cell structure and…”
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A time-calibrated phylogeny of southern hemisphere stoneflies: Testing for Gondwanan origins by McCulloch, Graham A., Wallis, Graham P., Waters, Jonathan M.

“…[Display omitted] •Reconstructed a time-calibrated phylogeny of southern hemisphere stoneflies.•Antitropical sub-orders likely diverged due to the ancient…”
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Chloroform in the environment: occurrence, sources, sinks and effects by McCulloch, A.

“…The chloroform flux through the environment is apparently constant at some 660±220 Gg yr −1 (±1 σ) and about 90% of the emissions are natural in origin: the…”
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Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator by Chen, A., Arora, P. D., McCulloch, C. A., Wilde, A.

“…Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the…”
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Impact of TRP Channels on Extracellular Matrix Remodeling: Focus on TRPV4 and Collagen by Wang, Qin, Ji, Chenfan, Smith, Patricio, McCulloch, Christopher A

“…Disturbed remodeling of the extracellular matrix (ECM) is frequently observed in several high-prevalence pathologies that include fibrotic diseases of organs…”
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A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII by Morotti, S., Edwards, A. G., McCulloch, A. D., Bers, D. M., Grandi, E.

“…Key points Intracellular [Na+] ([Na+]i) is elevated in heart failure (HF) and causes arrhythmogenic cellular [Ca2+]i loading. In HF, hyperactivity of…”
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