Search Results - "McCullagh, Karl"

The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research fields by Naldaiz‐Gastesi, Neia, Bahri, Ola A., López de Munain, Adolfo, McCullagh, Karl J. A., Izeta, Ander

“…The panniculus carnosus is a thin striated muscular layer intimately attached to the skin and fascia of most mammals, where it provides skin twitching and…”
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Microvascular Experimentation in the Chick Chorioallantoic Membrane as a Model for Screening Angiogenic Agents including from Gene-Modified Cells by Kennedy, Donna C, Coen, Barbara, Wheatley, Antony M, McCullagh, Karl J A

“…The chick chorioallantoic membrane (CAM) assay model of angiogenesis has been highlighted as a relatively quick, low cost and effective model for the study of…”
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Coaxing stem cells for skeletal muscle repair by McCullagh, Karl J.A., Perlingeiro, Rita C.R.

“…Skeletal muscle has a tremendous ability to regenerate, attributed to a well-defined population of muscle stem cells called satellite cells. However, this…”
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Elastin-like hydrogel stimulates angiogenesis in a severe model of critical limb ischemia (CLI): An insight into the glyco-host response by Marsico, Grazia, Jin, Chunseng, Abbah, Sunny A., Brauchle, Eva M., Thomas, Dilip, Rebelo, Ana Lúcia, Orbanić, Doriana, Chantepie, Sandrine, Contessotto, Paolo, Papy-Garcia, Dulce, Rodriguez-Cabello, Carlos, Kilcoyne, Michelle, Schenke-Layland, K., Karlsson, N.G., McCullagh, Karl J.A., Pandit, Abhay

“…Critical limb ischemia (CLI) is characterized by the impairment of microcirculation, necrosis and inflammation of the muscular tissue. Although the role of…”
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The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse by Bahri, Ola A., Naldaiz-Gastesi, Neia, Kennedy, Donna C., Wheatley, Antony M., Izeta, Ander, McCullagh, Karl J. A.

“…The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is…”
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VEGF-A and FGF4 Engineered C2C12 Myoblasts and Angiogenesis in the Chick Chorioallantoic Membrane by Kennedy, Donna C, Wheatley, Antony M, McCullagh, Karl J. A

“…Angiogenesis is the formation of new blood vessels from pre-existing vessels. Adequate oxygen transport and waste removal are necessary for tissue homeostasis…”
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IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1 by Musaro, A., McCullagh, K. J., Naya, F. J., Olson, E. N., Rosenthal, N.

“…Localized synthesis of insulin-like growth factors (IGFs) has been broadly implicated in skeletal muscle growth, hypertrophy and regeneration. Virally…”
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NFAT Is a Nerve Activity Sensor in Skeletal Muscle and Controls Activity-Dependent Myosin Switching by Karl J. A. Mc Cullagh, Calabria, Elisa, Pallafacchina, Giorgia, Ciciliot, Stefano, Serrano, Antonio L., Argentini, Carla, Kalhovde, John M., Lømo, Terje, Schiaffino, Stefano, Crabtree, Gerald R.

“…Calcineurin (Cn) signaling has been implicated in nerve activity-dependent fiber type specification in skeletal muscle, but the downstream effector pathway has…”
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Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons by Clarke, W. Thomas, Edwards, Ben, McCullagh, Karl J.A, Kemp, Matthew W, Moorwood, Catherine, Sherman, Diane L, Burgess, Matthew, Davies, Kay E

“…Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein…”
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Can a young muscle's stem cell secretome prolong our lives? by McCullagh, Karl J A

“…Ageing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which…”
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Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse by McCullagh, Karl J. A., Edwards, Ben, Kemp, Matthew W., Giles, Laura C., Burgess, Matthew, Davies, Kay E.

“…Syncoilin is a 64-kDa intermediate filament protein expressed in skeletal muscle and enriched at the perinucleus, sarcolemma, and myotendinous and…”
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naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration by Lara-Pezzi, Enrique, Winn, Nadine, Paul, Angelika, McCullagh, Karl, Slominsky, Esfir, Santini, Maria Paola, Mourkioti, Foteini, Sarathchandra, Padmini, Fukushima, Satsuki, Suzuki, Ken, Rosenthal, Nadia

“…The calcium-activated phosphatase calcineurin (Cn) transduces physiological signals through intracellular pathways to influence the expression of specific…”
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Intermediate filament-like protein syncoilin in normal and myopathic striated muscle by McCullagh, Karl J.A, Edwards, Ben, Poon, Ellen, Lovering, Richard M, Paulin, Denise, Davies, Kay E

“…Abstract The intermediate filament-like protein syncoilin is a member of the dystrophin protein complex, and links the complex to the cytoskeleton through…”
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Training intensity-dependent and tissue-specific increases in lactate uptake and MCT-1 in heart and muscle by Baker, Steven K, McCullagh, Karl J. A, Bonen, Arend

“…Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1 We investigated the effects of 3 wk of moderate- (21 m/min, 8% grade) and…”
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Revisiting calcineurin and human heart failure by Rosenthal, Nadia, Tsao, Lana, Neville, Craig, Musaro, Antonio, McCullagh, Karl J.A

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Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle by McCullagh, K J, Poole, R C, Halestrap, A P, Tipton, K F, O'Brien, M, Bonen, A

“…We examined whether chronic stimulation of red and white rat muscles increased the concentrations of the monocarboxylate transporter MCT1. Red and white…”
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Cellular and Subcellular Expression of the Monocarboxylate Transporter MCT1 in Rat Heart: A High-Resolution Immunogold Analysis by Johannsson, Erlingur, Nagelhus, Erlend A, McCullagh, Karl J.A, Sejersted, Ole M, Blackstad, Theodor W, Bonen, Arend, Ottersen, Ole P

“…An antibody to the C-terminus of the monocarboxylate transporter MCT1 was used to study the precise cellular and subcellular distribution of this transporter…”
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Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle by Rosenthal, Nadia, Musarò, Antonio, McCullagh, Karl, Paul, Angelika, Houghton, Leslie, Dobrowolny, Gabriella, Molinaro, Mario, Barton, Elisabeth R, L Sweeney, H

“…Aging skeletal muscles suffer a steady decline in mass and functional performance, and compromised muscle integrity as fibrotic invasions replace contractile…”
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Liposomal surface coatings of metal stents for efficient non-viral gene delivery to the injured vasculature by Ganly, Sandra, Hynes, Sean O., Sharif, Faisal, Aied, Ahmed, Barron, Valerie, McCullagh, Karl, McMahon, Jill, McHugh, Peter, Crowley, Jim, Wang, Wenxin, O'Brien, Timothy, Greiser, Udo

“…Despite the widespread use of drug eluting stents (DES), in-stent restenosis (ISR), delayed arterial healing and thrombosis remain important clinical…”
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Role of the lactate transporter (MCT1) in skeletal muscles by McCullagh, K J, Poole, R C, Halestrap, A P, O'Brien, M, Bonen, A

“…We used an antibody, constructed against the monocarboxylate transporter 1 (MCT1) protein (L. Carpenter, R. C. Poole, and A. P. Halestrap. Biochim. Biophys…”
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