Search Results - "McCue, M. E."

Predicted genetic burden and frequency of phenotype-associated variants in the horse by Durward-Akhurst, S. A., Marlowe, J. L., Schaefer, R. J., Springer, K., Grantham, B., Carey, W. K., Bellone, R. R., Mickelson, J. R., McCue, M. E.

“…Disease-causing variants have been identified for less than 20% of suspected equine genetic diseases. Whole genome sequencing (WGS) allows rapid identification…”
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Genetic Variation and the Distribution of Variant Types in the Horse by Durward-Akhurst, S A, Schaefer, R J, Grantham, B, Carey, W K, Mickelson, J R, McCue, M E

“…Genetic variation is a key contributor to health and disease. Understanding the link between an individual's genotype and the corresponding phenotype is a…”
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Whole genome sequencing identified a 16 kilobase deletion on ECA13 associated with distichiasis in Friesian horses by Hisey, E A, Hermans, H, Lounsberry, Z T, Avila, F, Grahn, R A, Knickelbein, K E, Duward-Akhurst, S A, McCue, M E, Kalbfleisch, T S, Lassaline, M E, Back, W, Bellone, R R

“…Distichiasis, an ocular disorder in which aberrant cilia (eyelashes) grow from the opening of the Meibomian glands of the eyelid, has been reported in Friesian…”
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Associations between endocrine disrupting chemicals and equine metabolic syndrome phenotypes by Durward-Akhurst, S.A., Schultz, N.E., Norton, E.M., Rendahl, A.K., Besselink, H., Behnisch, P.A., Brouwer, A., Geor, R.J., Mickelson, J.R., McCue, M.E.

“…Equine Metabolic Syndrome (EMS) is characterized by abnormalities in insulin regulation, increased adiposity and laminitis, and has several similarities to…”
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Genetic risk factors for insidious equine recurrent uveitis in Appaloosa horses by Fritz, K. L., Kaese, H. J., Valberg, S. J., Hendrickson, J. A., Rendahl, A. K., Bellone, R. R., Dynes, K. M., Wagner, M. L., Lucio, M. A., Cuomo, F. M., Brinkmeyer-Langford, C. L., Skow, L. C., Mickelson, J. R., Rutherford, M. S., McCue, M. E.

“…Summary Appaloosa horses are predisposed to equine recurrent uveitis (ERU), an immune‐mediated disease characterized by recurring inflammation of the uveal…”
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Estimation of body weight and development of a body weight score for adult equids using morphometric measurements1 by Martinson, K. L., Coleman, R. C., Rendahl, A. K., Fang, Z., McCue, M. E.

“…Excessive BW has become a major health issue in the equine (Equus caballus) industry. The objectives were to determine if the addition of neck circumference…”
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Presence of the glycogen synthase 1 (GYS1) mutation causing type 1 polysaccharide storage myopathy in continental European draught horse breeds by Baird, J. D., Valberg, S. J., Anderson, S. M., McCue, M. E., Mickelson, J. R.

“…The purpose of this study was to determine which continental European draught horse breeds harbour a mutation in the glycogen synthase 1 gene (GYS1) that is…”
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Equine developmental orthopaedic diseases - a genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters by Lykkjen, S., Dolvik, N. I., McCue, M. E., Rendahl, A. K., Mickelson, J. R., Røed, K. H.

“…Summary Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used…”
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Genetic mapping of recurrent exertional rhabdomyolysis in a population of North American Thoroughbreds by Fritz, K. L., McCue, M. E., Valberg, S. J., Rendahl, A. K., Mickelson, J. R.

“…Summary Recurrent exertional rhabdomyolysis is a heritable disorder that results in painful skeletal muscle cramping with exercise in up to 10% of all…”
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Heritability of metabolic traits associated with equine metabolic syndrome in Welsh ponies and Morgan horses by Norton, E. M., Schultz, N. E., Rendahl, A. K., Mcfarlane, D., Geor, R. J., Mickelson, J. R., McCue, M. E.

“…Summary Background Equine metabolic syndrome (EMS) is a complex clinical disorder with both environmental and genetic factors contributing to EMS phenotypes…”
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Polysaccharide storage myopathy phenotype in quarter horse-related breeds is modified by the presence of an RYR1 mutation by McCue, M.E, Valberg, S.J, Jackson, M, Borgia, L, Lucio, M, Mickelson, J.R

“…Abstract In this study we examined a family of Quarter Horses with Polysaccharide Storage Myopathy (PSSM) with a dominant mutation in the skeletal muscle…”
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Effect of age and dietary carbohydrate profiles on glucose and insulin dynamics in horses by Jacob, S. I., Geor, R. J., Weber, P. S. D., Harris, P. A., McCue, M. E.

“…Summary Background Glucose and insulin dynamics may be different in adult and aged horses. Objectives To determine the effects of age and dietary carbohydrates…”
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Harnessing big data for equine health by McCue, M. E., McCoy, A. M.

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SNP‐based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers by Cook, S. R., Conzemius, M. G., McCue, M. E., Ekenstedt, K. J.

“…Summary Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this…”
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Equine recombination map updated to EquCab3.0 by Beeson, S. K., Mickelson, J. R., McCue, M. E.

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Estimation of body weight and development of a body weight score for adult equids using morphometric measurements by Martinson, K L, Coleman, R C, Rendahl, A K, Fang, Z, McCue, M E

“…Excessive BW has become a major health issue in the equine (Equus caballus) industry. The objectives were to determine if the addition of neck circumference…”
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SNP‐based heritability and genetic architecture of tarsal osteochondrosis in North American Standardbred horses by McCoy, A. M., Norton, E. M., Kemper, A. M., Beeson, S. K., Mickelson, J. R., McCue, M. E.

“…Summary Osteochondrosis is a common developmental orthopedic disease characterized by a failure of endochondral ossification. Standardbred horses are…”
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Effect of dietary carbohydrates and time of year on ACTH and cortisol concentrations in adult and aged horses by Jacob, S.I., Geor, R.J., Weber, P.S.D., Harris, P.A., McCue, M.E.

“…Diagnosis of equine pituitary pars intermedia dysfunction (PPID) remains a challenge as multiple factors (stress, exercise, and time of year) influence ACTH…”
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GYS1 gene mutation is highly associated with polysaccharide storage myopathy in Cob Normand draught horses by Herszberg, B, McCue, M.E, Larcher, T, Mata, X, Vaiman, A, Chaffaux, S, Chérel, Y, Valberg, S.J, Mickelson, J.R, Guérin, G

“…Glycogen storage diseases or glycogenoses are inherited diseases caused by abnormalities of enzymes that regulate the synthesis or degradation of glycogen…”
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Assessment of the FAM174A 11G allele as a risk allele for equine metabolic syndrome by Roy, M. M., Norton, E. M., Rendahl, A. K., Schultz, N. E., McFarlane, D., Geor, R. J., Mickelson, J. R., McCue, M. E.

“…Summary An 11G nucleotide repeat in the 3′ UTR of FAM174A was recently postulated as a risk allele with a dominant mode of inheritance for equine metabolic…”
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