Search Results - "McCubrey, James A"

Current treatment strategies for inhibiting mTOR in cancer by Chiarini, Francesca, Evangelisti, Camilla, McCubrey, James A, Martelli, Alberto M

“…Highlights • We delineate the roles of mTOR in the biology of healthy and cancer cells. • We focus on the current therapeutic strategies used to inhibit mTOR…”
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GSK-3: a multifaceted player in acute leukemias by Martelli, Alberto M., Evangelisti, Camilla, Paganelli, Francesca, Chiarini, Francesca, McCubrey, James A.

“…Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were originally linked to glucose metabolism regulation. However, GSK-3 is also…”
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Targeting GSK3 and Associated Signaling Pathways Involved in Cancer by Duda, Przemysław, Akula, Shaw M, Abrams, Stephen L, Steelman, Linda S, Martelli, Alberto M, Cocco, Lucio, Ratti, Stefano, Candido, Saverio, Libra, Massimo, Montalto, Giuseppe, Cervello, Melchiorre, Gizak, Agnieszka, Rakus, Dariusz, McCubrey, James A

“…Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of…”
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RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma by Akula, Shaw M, Abrams, Stephen L, Steelman, Linda S, Emma, Maria R, Augello, Giuseppa, Cusimano, Antonella, Azzolina, Antonina, Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A

“…: Hepatocellular carcinoma (HCC) is a significant problem globally because of viral infections and the increasing incidence of obesity and fatty liver disease…”
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Understanding the Roles of the Hedgehog Signaling Pathway during T-Cell Lymphopoiesis and in T-Cell Acute Lymphoblastic Leukemia (T-ALL) by Martelli, Alberto M, Paganelli, Francesca, Truocchio, Serena, Palumbo, Carla, Chiarini, Francesca, McCubrey, James A

“…The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and vertebrate embryonic development. Along with other networks, such as…”
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Molecular mechanisms of sorafenib action in liver cancer cells by Cervello, Melchiorre, Bachvarov, Dimcho, Lampiasi, Nadia, Cusimano, Antonella, Azzolina, Antonina, McCubrey, James A., Montalto, Giuseppe

“…Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical…”
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Senescence-Associated Exosome Release from Human Prostate Cancer Cells by LEHMANN, Brian D, PAINE, Matthew S, BROOKS, Adam M, MCCUBREY, James A, RENEGAR, Randall H, RONG WANG, TERRIAN, David M

“…Males of advanced age represent a rapidly growing population at risk for prostate cancer. In the contemporary setting of earlier detection, a majority of…”
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TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer by Akula, Shaw M, Ruvolo, Peter P, McCubrey, James A

“…Pancreatic ductal adenocarcinoma (PDAC) is a disease of aging. The gene product regulates cell growth, aging, and cancer. To determine the important targets of…”
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Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance by McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Wong, Ellis W.T., Chang, Fumin, Lehmann, Brian, Terrian, David M., Milella, Michele, Tafuri, Agostino, Stivala, Franca, Libra, Massimo, Basecke, Jorg, Evangelisti, Camilla, Martelli, Alberto M., Franklin, Richard A.

“…Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent…”
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Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells by Chiarini, Francesca, Evangelisti, Camilla, Lattanzi, Giovanna, McCubrey, James A., Martelli, Alberto M.

“…The development of drug-resistance by neoplastic cells is recognized as a major cause of targeted therapy failure and disease progression. The mechanistic…”
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Targeted therapy for hepatocellular carcinoma: novel agents on the horizon by Cervello, Melchiorre, McCubrey, James A, Cusimano, Antonella, Lampiasi, Nadia, Azzolina, Antonina, Montalto, Giuseppe

“…Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most…”
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Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update by Evangelisti, Camilla, Chiarini, Francesca, McCubrey, James A, Martelli, Alberto M

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood malignancy that arises from the clonal expansion of transformed T-cell precursors. Although…”
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Impact of physical exercise in cancer survivors during and after antineoplastic treatments by Ferioli, Martina, Zauli, Giorgio, Martelli, Alberto M, Vitale, Marco, McCubrey, James A, Ultimo, Simona, Capitani, Silvano, Neri, Luca M

“…Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological…”
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Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention by Davis, Nicole M, Sokolosky, Melissa, Stadelman, Kristin, Abrams, Steve L, Libra, Massimo, Candido, Saverio, Nicoletti, Ferdinando, Polesel, Jerry, Maestro, Roberta, D'Assoro, Antonino, Drobot, Lyudmyla, Rakus, Dariusz, Gizak, Agnieszka, Laidler, Piotr, Dulińska-Litewka, Joanna, Basecke, Joerg, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Montalto, Giuseppe, Cervello, Melchiorre, Fitzgerald, Timothy L, Demidenko, Zoya, Martelli, Alberto M, Cocco, Lucio, Steelman, Linda S, McCubrey, James A

“…The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant transformation, prevention of apoptosis, drug resistance and metastasis. The…”
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Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer by Pappalardo, Francesco, Russo, Giulia, Candido, Saverio, Pennisi, Marzio, Cavalieri, Salvatore, Motta, Santo, McCubrey, James A, Nicoletti, Ferdinando, Libra, Massimo

“…Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to…”
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Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation by Cusimano, Antonella, Balasus, Daniele, Azzolina, Antonina, Augello, Giuseppa, Emma, Maria R, Di Sano, Caterina, Gramignoli, Roberto, Strom, Stephen C, Mccubrey, James A, Montalto, Giuseppe, Cervello, Melchiorre

“…The beneficial health properties of the Mediterranean diet are well recognized. The principle source of fat in Mediterranean diet is extra-virgin olive oil…”
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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging by Steelman, Linda S, Chappell, William H, Abrams, Stephen L, Kempf, Ruth C, Long, Jacquelyn, Laidler, Piotr, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Stivala, Franca, Mazzarino, Maria C, Donia, Marco, Fagone, Paolo, Malaponte, Graziella, Nicoletti, Ferdinando, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Bonati, Antonio, Bäsecke, Jörg, Cocco, Lucio, Evangelisti, Camilla, Martelli, Alberto M, Montalto, Giuseppe, Cervello, Melchiorre, McCubrey, James A

“…Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these…”
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Identification of SLC22A17 DNA methylation hotspot as a potential biomarker in cutaneous melanoma by Lavoro, Alessandro, Falzone, Luca, Gattuso, Giuseppe, Conti, Giuseppe N, Caltabiano, Rosario, Madonna, Gabriele, Capone, Mariaelena, McCubrey, James A, Ascierto, Paolo A, Libra, Massimo, Candido, Saverio

“…Cancer onset and progression are driven by genetic and epigenetic alterations leading to oncogene activation and the silencing of tumor suppressor genes. Among…”
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Signaling Role of Pericytes in Vascular Health and Tissue Homeostasis by Fazio, Antonietta, Neri, Irene, Koufi, Foteini-Dionysia, Marvi, Maria Vittoria, Galvani, Andrea, Evangelisti, Camilla, McCubrey, James A, Cocco, Lucio, Manzoli, Lucia, Ratti, Stefano

“…Pericytes are multipotent cells embedded within the vascular system, primarily surrounding capillaries and microvessels where they closely interact with…”
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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells by McCubrey, James A, Fitzgerald, Timothy L, Yang, Li V, Lertpiriyapong, Kvin, Steelman, Linda S, Abrams, Stephen L, Montalto, Giuseppe, Cervello, Melchiorre, Neri, Luca M, Cocco, Lucio, Martelli, Alberto M, Laidler, Piotr, Dulińska-Litewka, Joanna, Rakus, Dariusz, Gizak, Agnieszka, Nicoletti, Ferdinando, Falzone, Luca, Candido, Saverio, Libra, Massimo

“…Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin,…”
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