Search Results - "McCreery, Kaitlin P."
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Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo
Published in npj Regenerative medicine (28-09-2024)“…The repair of articular cartilage after damage is challenging, and decellularized tissue offers a possible treatment option to promote regeneration. Here, we…”
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Hyperelastic characterization reveals proteoglycans drive the nanoscale strain-stiffening response in hyaline cartilage
Published in Journal of biomechanics (01-01-2023)“…Degenerative diseases such as osteoarthritis (OA) result in deterioration of cartilage extracellular matrix (ECM) components, significantly compromising tissue…”
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Nuclear Stiffness Decreases with Disruption of the Extracellular Matrix in Living Tissues
Published in Small (Weinheim an der Bergstrasse, Germany) (01-02-2021)“…Reciprocal interactions between the cell nucleus and the extracellular matrix lead to macroscale tissue phenotype changes. However, little is known about how…”
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Ontogeny informs regeneration: explant models to investigate the role of the extracellular matrix in cartilage tissue assembly and development
Published in Connective tissue research (03-07-2020)“…Osteoarthritis (OA) is typically managed in late stages by replacement of the articular cartilage surface with a prosthesis as an effective, though undesirable…”
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Mechanical loading is required for initiation of extracellular matrix deposition at the developing murine myotendinous junction
Published in Matrix biology (01-02-2023)“…•Specification of ECM at the murine MTJ depended on muscle contraction.•Knockout of Tbx3 resulted in an ectopic muscle that inserted into an MTJ.•Ectopic MTJ…”
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Particulate ECM biomaterial ink is 3D printed and naturally crosslinked to form structurally-layered and lubricated cartilage tissue mimics
Published in Biofabrication (01-04-2022)“…Articular cartilage is a layered tissue with a complex, heterogeneous structure and lubricated surface which is challenging to reproduce using traditional…”
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