Search Results - "McCrea, Heather J."

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies by Park, Tae-Eun, Mustafaoglu, Nur, Herland, Anna, Hasselkus, Ryan, Mannix, Robert, FitzGerald, Edward A., Prantil-Baun, Rachelle, Watters, Alexander, Henry, Olivier, Benz, Maximilian, Sanchez, Henry, McCrea, Heather J., Goumnerova, Liliana Christova, Song, Hannah W., Palecek, Sean P., Shusta, Eric, Ingber, Donald E.

“…The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous…”
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Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease by McCrea, Heather J, De Camilli, Pietro

“…Heather J. McCrea and Pietro De Camilli Howard Hughes Medical Institute, Departments of Cell Biology and Neurobiology, Kavli Institute for Neuroscience,…”
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Myelomeningocele-associated hydrocephalus: nationwide analysis and systematic review by McCarthy, David J, Sheinberg, Dallas L, Luther, Evan, McCrea, Heather J

“…Myelomeningocele (MMC), the most severe form of spina bifida, is characterized by protrusion of the meninges and spinal cord through a defect in the vertebral…”
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The Diagnosis, Management, and Postnatal Prevention of Intraventricular Hemorrhage in the Preterm Neonate by McCrea, Heather J., PhD, Ment, Laura R., MD

“…Intraventricular hemorrhage (IVH) occurs in 20% to 25% of very low birthweight preterm neonates and may be associated with significant sequelae. Infants who…”
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Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study by Chakraborty, Shamik, Filippi, Christopher G., Wong, Tamika, Ray, Ashley, Fralin, Sherese, Tsiouris, A. John, Praminick, Bidyut, Demopoulos, Alexis, McCrea, Heather J., Bodhinayake, Imithri, Ortiz, Rafael, Langer, David J., Boockvar, John A.

“…Objective To establish a maximum tolerated dose of superselective intraarterial cerebral infusion (SIACI) of Cetuximab after osmotic disruption of the…”
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A Role of the Lowe Syndrome Protein OCRL in Early Steps of the Endocytic Pathway by Erdmann, Kai S., Mao, Yuxin, McCrea, Heather J., Zoncu, Roberto, Lee, Sangyoon, Paradise, Summer, Modregger, Jan, Biemesderfer, Daniel, Toomre, Derek, De Camilli, Pietro

“…Mutations in the inositol 5-phosphatase OCRL are responsible for Lowe syndrome, whose manifestations include mental retardation and renal Fanconi syndrome…”
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Claudins create charge-selective channels in the paracellular pathway between epithelial cells by Colegio, Oscar R, Van Itallie, Christina M, McCrea, Heather J, Rahner, Christoph, Anderson, James Melvin

“…Epithelia separate tissue spaces by regulating the passage of ions, solutes, and water through both the transcellular and paracellular pathways. Paracellular…”
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All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding by McCrea, Heather J., Paradise, Summer, Tomasini, Livia, Addis, Maria, Melis, Maria Antonietta, De Matteis, Maria Antonietta, De Camilli, Pietro

“…Mutations in the inositol 5-phosphatase OCRL are responsible for Lowe syndrome, an X-linked disorder characterized by bilateral cataracts, mental retardation,…”
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Large sphenoid mucocele presenting with cranial neuropathies in a 10-year-old boy: case report and literature review by Chang, Henry, Silva, Michael, Weng, John, Reilly, Erin, Levine, Corinna, McCrea, Heather J.

“…Introduction Mucoceles in the sphenoid sinus are rare, making up 1–3% of all paranasal sinus mucoceles. Sphenoid sinus mucoceles among pediatric patients are…”
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EGFR amplification and classical subtype are associated with a poor response to bevacizumab in recurrent glioblastoma by Hovinga, Koos E., McCrea, Heather J., Brennan, Cameron, Huse, Jason, Zheng, Junting, Esquenazi, Yoshua, Panageas, Katherine S., Tabar, Viviane

“…Purpose The highly vascular malignant brain tumor glioblastoma (GBM) appears to be an ideal target for anti-angiogenic therapy; however, clinical trials to…”
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Intracranial arachnoid cysts in an infant: A technical note on the innovative use of navigation and flexible endoscopy for cyst fenestration by Sprau, Annelise Claire, McCrea, Heather J.

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Intraarterial delivery of bevacizumab and cetuximab utilizing blood-brain barrier disruption in children with high-grade glioma and diffuse intrinsic pontine glioma: results of a phase I trial by McCrea, Heather J, Ivanidze, Jana, O'Connor, Ashley, Hersh, Eliza H, Boockvar, John A, Gobin, Y Pierre, Knopman, Jared, Greenfield, Jeffrey P

“…Delivery of drugs intraarterially to brain tumors has been demonstrated in adults. In this study, the authors initiated a phase I trial of superselective…”
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Evaluating the potential role of determinants of health on encephalocele patient outcomes — a combined retrospective study and systematic review by Escobar, Victoria A. Pinilla, Wyant, W. Austin, Debs, Luca H., Jamshidi, Aria, Kiehna, Erin N., McCrea, Heather J.

“…Introduction To evaluate the outcomes and demographics of encephalocele patients who were born and received treatment in our neonatal ICU and conduct a PRISMA…”
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A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog-Dependent Tumor Growth by Yang, Fan, Rodriguez-Blanco, Jezabel, Long, Jun, Swiderska-Syn, Marzena, Wynn, Daniel T, Li, Bin, Shen, Chen, Nayak, Anmada, Ban, Yuguang, Sun, Xiaodian, Suter, Robert K, McCrea, Heather J, Capobianco, Anthony J, Ayad, Nagi G, Robbins, David J

“…Dysregulation of Sonic hedgehog (SHH) signaling drives the growth of distinct cancer subtypes, including medulloblastoma (MB). Such cancers have been treated…”
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Assessment of neuromonitoring use and postoperative readmission rates in pediatric Chiari I malformation with syrinx by Gilna, Gareth P., Clarke, Jamie E., Silva, Michael, Saberi, Rebecca A., Parreco, Joshua P., Thorson, Chad M., McCrea, Heather J.

“…Introduction While operative intervention for Chiari malformation type I (CMI) with syringomyelia is well established, there is limited data on outcomes of…”
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Triptolide and its prodrug Minnelide target high-risk MYC-amplified medulloblastoma in preclinical models by Rodriguez-Blanco, Jezabel, Salvador, April D, Suter, Robert K, Swiderska-Syn, Marzena, Palomo-Caturla, Isabel, Kliebe, Valentin, Shahani, Pritika, Peterson, Kendell, Turos-Cabal, Maria, Vieira, Megan E, Wynn, Daniel T, Howell, Ashley J, Yang, Fan, Ban, Yuguang, McCrea, Heather J, Zindy, Frederique, Danis, Etienne, Vibhakar, Rajeev, Jermakowicz, Anna, Martin, Vanesa, Coss, Christopher C, Harris, Brent T, de Cubas, Aguirre, Chen, X Steven, Barnoud, Thibaut, Roussel, Martine F, Ayad, Nagi G, Robbins, David J

“…Most children with medulloblastoma (MB) achieve remission, but some face very aggressive metastatic tumors. Their dismal outcome highlights the critical need…”
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A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma by Rodriguez-Blanco, Jezabel, Li, Bin, Long, Jun, Shen, Chen, Yang, Fan, Orton, Darren, Collins, Sara, Kasahara, Noriyuki, Ayad, Nagi G, McCrea, Heather J, Roussel, Martine F, Weiss, William A, Capobianco, Anthony J, Robbins, David J

“…Although most children with medulloblastoma are cured of their disease, Sonic Hedgehog (SHH) subgroup medulloblastoma driven by mutations is essentially…”
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Using intent to get ahead of pediatric cranial firearm injuries by Huerta, Carlos Theodore, Saberi, Rebecca A, Gilna, Gareth P, Escobar, Victoria A Pinilla, Perez, Eduardo A, Sola, Juan E, Thorson, Chad M, McCrea, Heather J

“…Pediatric firearm injuries (PFI) are a public health crisis. Little is known about how injury intent may influence the outcome of pediatric cranial firearm…”
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Clinical complications of surviving gunshot wounds to the head in children and adolescents: the Miami experience by Lu, Victor M., Kreuger, Evan, Cordeiro, Joacir G., Niazi, Toba N., Jagid, Jonathan R., McCrea, Heather J.

“…Background Gunshot wounds (GSWs) to the head in the pediatric population are both rare and devastating, with the clinical course of pediatric survivors poorly…”
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Pediatric Suprasellar Tumors by McCrea, Heather J., George, Emilie, Settler, Allison, Schwartz, Theodore H., Greenfield, Jeffrey P.

“…The various childhood suprasellar tumors, while pathologically distinct, present similar clinical and surgical challenges as a result of their common anatomic…”
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