Search Results - "McCrae, KR"

Annexin A2: biology and relevance to the antiphospholipid syndrome by Cockrell, E, Espinola, RG, McCrae, KR

“…Antiphospholipid antibodies (aPL), the majority of which are directed against β2-glycoprotein I (β2GPI), are associated with an increased incidence of venous…”
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EPH63 Identification of a Warm Autoimmune Hemolytic Anemia (wAIHA) Population Using Predictive Analytics of a Known Clinically Profiled Cohort by McCrae, KR, Gooljarsingh, T, Jones, GK, Tjoa, ML

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A Phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin A-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer by DOWLATI, Afshin, ROBERTSON, Kelly, TAYLOR, Anne, WAAS, John, LEWIN, Jonathan S, MCCRAE, Keith R, REMICK, Scot C, COONEY, Matthew, PETROS, William P, STRATFORD, Michael, JESBERGER, John, RAFIE, Niusha, OVERMOYER, Beth, MAKKAR, Vinit, STAMBLER, Bruce

“…Combretastatin A-4 phosphate (CA4P) is a novel antitumor vascular targeting agent, the first agent of this class of compounds to enter the clinic. We performed…”
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Thrombocytopenia in pregnancy: differential diagnosis, pathogenesis, and management by McCrae, Keith R

“…Thrombocytopenia in pregnant women may result from a number of diverse etiologies. While some of these are not associated with adverse pregnancy outcomes,…”
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Endothelial cells in physiology and in the pathophysiology of vascular disorders by CINES, D. B, POLLAK, E. S, BARNATHAN, E. S, MCCRAE, K. R, HUG, B. A, SCHMIDT, A.-M, STERN, D. M, BUCK, C. A, LOSCALZO, J, ZIMMERMAN, G. A, MCEVER, R. P, POBER, J. S, WICK, T. M, KONKLE, B. A, SCHWARTZ, B. S

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Human Monoclonal Antiphospholipid Antibodies Disrupt the Annexin A5 Anticoagulant Crystal Shield on Phospholipid Bilayers: Evidence from Atomic Force Microscopy and Functional Assay by Rand, Jacob H, Wu, Xiao-Xuan, Quinn, Anthony S, Chen, Pojen P, McCrae, Keith R, Bovill, Edwin G, Taatjes, Douglas J

“…The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by recurrent pregnancy losses and/or systemic vascular thrombosis in patients who…”
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Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway by Graham, Charles H., Fitzpatrick, Tania E., McCrae, Keith R.

“…Hypoxia underlies a number of biologic processes in which cellular migration and invasion occur. Because earlier studies have shown that the receptor for…”
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Thrombocytopenia in pregnancy: differential diagnosis, pathogenesis, and management

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Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain by JUAREZ, Jose C, XIAOJUN GUAN, MORGAN, William T, DONATE, Fernando, SHIPULINA, Natalya V, PLUNKETT, Marian L, PARRY, Graham C, SHAW, David Elliot, ZHANG, Jing-Chuan, RABBANI, Shafaat A, MCCRAE, Keith R, MAZAR, Andrew P

“…Histidine-proline-rich glycoprotein (HPRG) is an abundant multidomain plasma protein evolutionarily related to high-molecular-weight kininogen. The cleaved…”
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Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor by Colman, R W, Pixley, R A, Najamunnisa, S, Yan, W, Wang, J, Mazar, A, McCrae, K R

“…The urokinase receptor (uPAR) binds urokinase-type plasminogen activator (u-PA) through specific interactions with uPAR domain 1, and vitronectin through…”
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Helicobacter pylori and ITP: many questions, few answers by McCrae, Keith R.

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Two‐chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5 by Zhang, Jing‐Chuan, Claffey, Kevin, Sakthivel, Ramasamy, Darzynkiewicz, Zbigniev, Shaw, David Elliot, Leal, Juan, Wang, Yi‐chun, Lu, Feng‐min, McCrae, Keith R.

“…ABSTRACT We previously reported that the binding of two‐chain high molecular weight kininogen (HKa) to endothelial cells may occur through interactions with…”
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The Antiangiogenic Activity of Cleaved High Molecular Weight Kininogen Is Mediated through Binding to Endothelial Cell Tropomyosin by Zhang, Jing-Chuan, Doñate, Fernando, Qi, Xiaoping, Ziats, Nicholas P., Juarez, Jose C., Mazar, Andrew P., Pang, Yuan-Ping, McCrae, Keith R.

“…Conformationally altered proteins and protein fragments derived from the extracellular matrix and hemostatic system may function as naturally occurring…”
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Localization of transforming growth factor-beta at the human fetal-maternal interface: role in trophoblast growth and differentiation by Graham, C H, Lysiak, J J, McCrae, K R, Lala, P K

“…We examined the localization of transforming growth factor (TGF)-beta in first-trimester and term human decidua and chorionic villi and explored the role of…”
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Thrombotic microangiopathy during pregnancy by McCrae, K R, Cines, D B

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Pregnancy-Associated Thrombocytopenia: Pathogenesis and Management by McCrae, Keith R., Samuels, Philip, Schreiber, Alan D.

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Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients by GRAHAM, C. H, MCCRAE, K. R

“…OBJECTIVE: This study compared in vitro degradative properties of trophoblasts isolated from placentas of preeclamptic patients with those of trophoblasts…”
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The Very Low Density Lipoprotein Receptor Mediates the Cellular Catabolism of Lipoprotein Lipase and Urokinase-Plasminogen Activator Inhibitor Type I Complexes (∗) by Argraves, Kelley M., Battey, Frances D., MacCalman, Colin D., McCrae, Keith R., Gåfvels, Mats, Kozarsky, Karen F., Chappell, David A., Strauss, Jerome F., Strickland, Dudley K.

“…The very low density lipoprotein (VLDL) receptor binds apolipoprotein E-rich lipoproteins as well as the 39-kDa receptor-associated protein (RAP). Ligand…”
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Inhibition of angiogenesis by cleaved high molecular weight kininogen (HKa) and HKa domain 5 by McCrae, Keith R, Doñate, Fernando, Merkulov, Sergei, Sun, Danyu, Qi, Xiaoping, Shaw, David E

“…High molecular weight kininogen (HK) is an abundant, multi-domain plasma protein that circulates in plasma primarily in its single chain form. Proteolytic…”
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High Molecular Weight Kininogen Peptides Inhibit the Formation of Kallikrein on Endothelial Cell Surfaces and Subsequent Urokinase-Dependent Plasmin Formation by Lin, Yingzhang, Harris, Robert B., Yan, Wuyi, McCrae, Keith R., Zhang, Hong, Colman, Robert W.

“…A sequence of 31 amino acids (S565-K595) in domain 6 of the light chain of high molecular weight kininogen (HK) has previously been shown to be responsible for…”
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