Search Results - "McCrae, K R"

In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice by Shukla, M., Sekhon, U. D. S., Betapudi, V., Li, W., Hickman, D. A., Pawlowski, C. L., Dyer, M. R., Neal, M. D., McCrae, K. R, Sen Gupta, A.

“…Essentials Platelet transfusion suffers from availability, portability, contamination, and short shelf‐life. SynthoPlate™ (synthetic platelet technology) can…”
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Annexin A2: biology and relevance to the antiphospholipid syndrome by Cockrell, E, Espinola, RG, McCrae, KR

“…Antiphospholipid antibodies (aPL), the majority of which are directed against β2-glycoprotein I (β2GPI), are associated with an increased incidence of venous…”
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Endothelial cells in physiology and in the pathophysiology of vascular disorders by CINES, D. B, POLLAK, E. S, BARNATHAN, E. S, MCCRAE, K. R, HUG, B. A, SCHMIDT, A.-M, STERN, D. M, BUCK, C. A, LOSCALZO, J, ZIMMERMAN, G. A, MCEVER, R. P, POBER, J. S, WICK, T. M, KONKLE, B. A, SCHWARTZ, B. S

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A novel pathway of cellular activation mediated by antiphospholipid antibody‐induced extracellular vesicles by Wu, M., Barnard, J., Kundu, S., McCrae, K. R.

“…Summary Background Elevated levels of endothelial cell (EC)‐derived extracellular vesicles (EVs) circulate in patients with antiphospholipid antibodies…”
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The plasma kallikrein–kinin system: its evolution from contact activation by SCHMAIER, A. H., MCCRAE, K. R.

“…The plasma kallikrein–kinin system consists of the proteins factor XII (FXII), prekallikrein (PK), and high molecular weight kininogen. It was first recognized…”
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Localization of transforming growth factor-beta at the human fetal-maternal interface: role in trophoblast growth and differentiation by Graham, C H, Lysiak, J J, McCrae, K R, Lala, P K

“…We examined the localization of transforming growth factor (TGF)-beta in first-trimester and term human decidua and chorionic villi and explored the role of…”
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Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor by Colman, R W, Pixley, R A, Najamunnisa, S, Yan, W, Wang, J, Mazar, A, McCrae, K R

“…The urokinase receptor (uPAR) binds urokinase-type plasminogen activator (u-PA) through specific interactions with uPAR domain 1, and vitronectin through…”
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Two‐chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5 by Zhang, Jing‐Chuan, Claffey, Kevin, Sakthivel, Ramasamy, Darzynkiewicz, Zbigniev, Shaw, David Elliot, Leal, Juan, Wang, Yi‐chun, Lu, Feng‐min, McCrae, Keith R.

“…ABSTRACT We previously reported that the binding of two‐chain high molecular weight kininogen (HKa) to endothelial cells may occur through interactions with…”
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Thrombotic microangiopathy during pregnancy by McCrae, K R, Cines, D B

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Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry by Multhaupt, HA, Gafvels, ME, Kariko, K, Jin, H, Arenas-Elliot, C, Goldman, BI, Strauss, JF, 3rd, Angelin, B, Warhol, MJ, McCrae, KR

“…The recently cloned very low density lipoprotein (VLDL) receptor binds triglyceride-rich, apolipoprotein-E-containing lipoproteins with high affinity. The…”
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Pregnancy-Associated Thrombocytopenia: Pathogenesis and Management by McCrae, Keith R., Samuels, Philip, Schreiber, Alan D.

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Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients by GRAHAM, C. H, MCCRAE, K. R

“…OBJECTIVE: This study compared in vitro degradative properties of trophoblasts isolated from placentas of preeclamptic patients with those of trophoblasts…”
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Expression of urokinase receptors by human trophoblast. A histochemical and ultrastructural analysis by Multhaupt, H A, Mazar, A, Cines, D B, Warhol, M J, McCrae, K R

“…Through their ability to invade endometrium, remodel the uterine spiral arteries, and sustain placental blood fluidity, trophoblast cells play a central role…”
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Antiphospholipid antibody associated thrombosis: a consensus for treatment? by McCrae, K R

“…The results of several studies have demonstrated that antiphospholipid antibodies (APLA) are associated with an increased risk of both venous and arterial…”
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Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway by GRAHAM, C. H, FITZPATRICK, T. E, MCCRAE, K. R

“…Hypoxia underlies a number of biologic processes in which cellular migration and invasion occur. Because earlier studies have shown that the receptor for…”
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Detection of antitrophoblast antibodies in the sera of patients with anticardiolipin antibodies and fetal loss by MCCRAE, K. R, DEMICHELE, A. M, PREM PANDHI, BALSAI, M. J, SAMUELS, P, GRAHAM, C, LALA, P. K, CINES, D. B

“…Women with anticardiolipin antibodies (ACLA) are at increased risk for fetal loss. One potential explanation for this outcome is that sera from these…”
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Tissue-type plasminogen activator binding to human endothelial cells. Evidence for two distinct binding sites by Barnathan, E S, Kuo, A, Van der Keyl, H, McCrae, K R, Larsen, G R, Cines, D B

“…The endothelium may contribute to fibrinolysis through the binding of plasminogen activators or plasminogen activator inhibitors to the cell surface. Using a…”
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Posttransfusion purpura: Two unusual cases and a literature review by McCrae, Keith R., Herman, Jay H.

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Characterization of Urokinase Receptor Expression by Human Placental Trophoblasts by Zini, Jean-Marc, Murray, Susan C., Graham, Charles H., Lala, Peeyush K., Karikó, Katalin, Barnathan, Elliott S., Mazar, Andrew, Henkin, Jack, Cines, Douglas B., McCrae, Keith R.

“…The processes of implantation and placentation are both dependent on the invasion and remodeling of the uterine endometrium and vasculature by trophoblasts…”
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Interaction of Single-Chain Urokinase with its Receptor Induces the Appearance and Disappearance of Binding Epitopes within the Resultant Complex for Other Cell Surface Proteins by Higazi, Abd Al-Roof, Upson, Rosalyn H., Cohen, Robert L., Manuppello, Joseph, Bognacki, John, Henkin, Jack, McCrae, Keith R., Kounnas, Maria Z., Strickland, Dudley K., Preissner, Klaus T., Lawler, Jack, Cines, Douglas B.

“…Binding of urokinase-type plasminogen activator (uPA) to its glycosylphosphatidylinositol-anchored receptor (uPAR) initiates signal transduction, adhesion, and…”
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