Search Results - "McCracken, Kyle W."

Generation of human antral and fundic gastric organoids from pluripotent stem cells by Broda, Taylor R., McCracken, Kyle W., Wells, James M.

“…The human stomach contains two primary domains: the corpus, which contains the fundic epithelium, and the antrum. Each of these domains has distinct cell types…”
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Mechanisms of embryonic stomach development by McCracken, Kyle W., Wells, James M.

“…The stomach is a digestive organ that has important roles in human physiology and pathophysiology. The developmental origin of the stomach is the embryonic…”
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RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis by Pode-Shakked, Naomi, Slack, Megan, Sundaram, Nambirajan, Schreiber, Ruth, McCracken, Kyle W., Dekel, Benjamin, Helmrath, Michael, Kopan, Raphael

“…Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD) is a fatal genetic disorder characterized by complete absence or severe depletion of proximal tubules…”
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Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification by Trisno, Stephen L., Philo, Katherine E.D., McCracken, Kyle W., Catá, Emily M., Ruiz-Torres, Sonya, Rankin, Scott A., Han, Lu, Nasr, Talia, Chaturvedi, Praneet, Rothenberg, Marc E., Mandegar, Mohammad A., Wells, Susanne I., Zorn, Aaron M., Wells, James M.

“…Tracheal and esophageal disorders are prevalent in humans and difficult to accurately model in mice. We therefore established a three-dimensional organoid…”
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Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis by Rankin, Scott A., McCracken, Kyle W., Luedeke, David M., Han, Lu, Wells, James M., Shannon, John M., Zorn, Aaron M.

“…A small number of signaling pathways are used repeatedly during organogenesis, and they can have drastically different effects on the same population of cells…”
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A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification by Rankin, Scott A., Han, Lu, McCracken, Kyle W., Kenny, Alan P., Anglin, Christopher T., Grigg, Emily A., Crawford, Calyn M., Wells, James M., Shannon, John M., Zorn, Aaron M.

“…Organogenesis of the trachea and lungs requires a complex series of mesoderm-endoderm interactions mediated by WNT, BMP, retinoic acid (RA), and hedgehog (Hh),…”
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Modelling human development and disease in pluripotent stem-cell-derived gastric organoids by McCracken, Kyle W., Catá, Emily M., Crawford, Calyn M., Sinagoga, Katie L., Schumacher, Michael, Rockich, Briana E., Tsai, Yu-Hwai, Mayhew, Christopher N., Spence, Jason R., Zavros, Yana, Wells, James M.

“…The in vitro generation, from pluripotent stem cells, of three-dimensional human gastric organoids (hGOs) that contain a physiological gastric epithelium…”
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Generating human intestinal tissue from pluripotent stem cells in vitro by McCracken, Kyle W, Howell, Jonathan C, Wells, James M, Spence, Jason R

“…Here we describe a protocol for generating 3D human intestinal tissues (called organoids) in vitro from human pluripotent stem cells (hPSCs). To generate…”
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Directed differentiation of ureteric bud and collecting duct organoids from human pluripotent stem cells by Shi, Min, Fu, Ping, Bonventre, Joseph V., McCracken, Kyle W.

“…Developing models of human kidney tissue in vitro is an important challenge in regenerative nephrology research, given the paucity of novel and effective…”
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Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types by Shi, Min, McCracken, Kyle W., Patel, Ankit B., Zhang, Weitao, Ester, Lioba, Valerius, M. Todd, Bonventre, Joseph V.

“…Directed differentiation of human pluripotent stem cells (hPSCs) into functional ureteric and collecting duct (CD) epithelia is essential to kidney…”
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Wnt/β-catenin promotes gastric fundus specification in mice and humans by McCracken, Kyle W., Aihara, Eitaro, Martin, Baptiste, Crawford, Calyn M., Broda, Taylor, Treguier, Julie, Zhang, Xinghao, Shannon, John M., Montrose, Marshall H., Wells, James M.

“…Despite the global prevalence of gastric disease, there are few adequate models in which to study the fundus epithelium of the human stomach. We differentiated…”
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Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis by Li, Li, Galichon, Pierre, Xiao, Xiaoyan, Figueroa-Ramirez, Ana C, Tamayo, Diana, Lee, Jake J-K, Kalocsay, Marian, Gonzalez-Sanchez, David, Chancay, Maria S, McCracken, Kyle W, Lee, Nathan N, Ichimura, Takaharu, Mori, Yutaro, Valerius, M Todd, Wilflingseder, Julia, Lemos, Dario R, Edelman, Elazer R, Bonventre, Joseph V

“…Recent studies demonstrate that metabolic disturbance, such as augmented glycolysis, contributes to fibrosis. The molecular regulation of this metabolic…”
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Molecular pathways controlling pancreas induction by McCracken, Kyle W., Wells, James M.

“…► Establishing the A–P and D–V axis of the gut tube is essential for pancreas induction. ► There are several differences between dorsal and ventral pancreas…”
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Arx is required for normal enteroendocrine cell development in mice and humans by Du, Aiping, McCracken, Kyle W., Walp, Erik R., Terry, Natalie A., Klein, Thomas J., Han, Annie, Wells, James M., May, Catherine Lee

“…Enteroendocrine cells of the gastrointestinal (GI) tract play a central role in metabolism, digestion, satiety and lipid absorption, yet their development…”
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Erratum: Wnt/β-catenin promotes gastric fundus specification in mice and humans by McCracken, Kyle W., Aihara, Eitaro, Martin, Baptiste, Crawford, Calyn M., Broda, Taylor, Treguier, Julie, Zhang, Xinghao, Shannon, John M., Montrose, Marshall H., Wells, James M.

“…Nature 541, 182–187 (2017); doi:10.1038/nature21021 In Fig. 1 of this Article, owing to an error during the production process, the bottom image was…”
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Generating human antral and fundic gastric organoids from pluripotent stem cells by Broda, Taylor R., McCracken, Kyle W., Wells, James M.

“…The human stomach contains two primary domains, the corpus containing fundic epithelium, and the antrum. Here we detail two methods to differentiate human…”
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Erratum: Wnt/-catenin promotes gastric fundus specification in mice and humans by McCracken, Kyle W, Aihara, Eitaro, Martin, Baptiste, Crawford, Calyn M, Broda, Taylor, Treguier, Julie, Zhang, Xinghao, Shannon, John M, Montrose, Marshall H, Wells, James M

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Wnt/-catenin promotes gastric fundus specification in mice and humans by McCracken, Kyle W, Aihara, Eitaro, Martin, Baptiste, Crawford, Calyn M, Broda, Taylor, Treguier, Julie, Zhang, Xinghao, Shannon, John M, Montrose, Marshall H, Wells, James M

“…Despite the global prevalence of gastric disease, there are few adequate models in which to study the fundus epithelium of the human stomach. We differentiated…”
Get full text