Search Results - "McCoy, Melissa K"

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease by McCoy, Melissa K, Tansey, Malú G

“…The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated but its function in the brain is still unclear. TNF receptor 1 (TNFR1)…”
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DJ-1 regulation of mitochondrial function and autophagy through oxidative stress by McCoy, Melissa K., Cookson, Mark R.

“…The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson disease. Mutations in the parkin, PINK1 and DJ-1 genes all…”
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Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention by Tansey, Malú G., McCoy, Melissa K., Frank-Cannon, Tamy C.

“…Most acute and chronic neurodegenerative conditions are accompanied by neuroinflammation; yet the exact nature of the inflammatory processes and whether they…”
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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy by THOMAS, Kelly Jean, MCCOY, Melissa K, BLACKINTON, Jeff, BEILINA, Alexandra, VAN DER BRUG, Marcel, SANDEBRING, Anna, MILLER, David, MARIC, Dragan, CEDAZO-MINGUEZ, Angel, COOKSON, Mark R

“…Mutations in DJ-1, PINK1 (PTEN-induced putative kinase 1) and parkin all cause recessive parkinsonism in humans, but the relationships between these genes are…”
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Hexokinase activity is required for recruitment of parkin to depolarized mitochondria by McCoy, Melissa K, Kaganovich, Alice, Rudenko, Iakov N, Ding, Jinhui, Cookson, Mark R

“…Autosomal recessive parkinsonism genes contribute to maintenance of mitochondrial function. Two of these, PINK1 and parkin, act in a pathway promoting…”
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Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats by McCoy, Melissa K, Ruhn, Kelly A, Martinez, Terina N, McAlpine, Fiona E, Blesch, Armin, Tansey, Malú G

“…Neuroinflammatory processes have been implicated in the progressive loss of ventral midbrain dopaminergic (DA) neurons that give rise to Parkinson's disease…”
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The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection by Tran, Thi A, McCoy, Melissa K, Sporn, Michael B, Tansey, Malú G

“…Recent animal and human studies implicate chronic activation of microglia in the progressive loss of CNS neurons. The inflammatory mechanisms that have…”
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Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease by McCoy, Melissa K., Martinez, Terina N., Ruhn, Kelly A., Wrage, Philip C., Keefer, Edward W., Botterman, Barry R., Tansey, Keith E., Tansey, Malú G.

“…Adult adipose contains stromal progenitor cells with neurogenic potential. However, the stability of neuronal phenotypes adopted by Adipose-Derived Adult…”
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Mitochondrial quality control and dynamics in Parkinson's disease by McCoy, Melissa K, Cookson, Mark R

“…Studies of sporadic cases, toxin models, and genetic causes of Parkinson's disease suggest that mitochondrial dysfunction may be an early feature of…”
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mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex by Dillman, Allissa A, Hauser, David N, Gibbs, J Raphael, Nalls, Michael A, McCoy, Melissa K, Rudenko, Iakov N, Galter, Dagmar, Cookson, Mark R

“…Using whole-transcriptome RNA sequencing at single-nucleotide resolution, this Resource article describes the mRNAs, RNA editing, splice variants and…”
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Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function by Rodrigues-dos-Santos, Karina, Roy, Gitanjali, Binns, Derk D, Grzemska, Magdalena G, Barella, Luiz F, Armoo, Fiona, McCoy, Melissa K, Huynh, Andy V, Yang, Jonathan Z, Posner, Bruce A, Cobb, Melanie H, Kalwat, Michael A

“…Pancreatic islet beta cells require a fine-tuned endoplasmic reticulum (ER) stress response for normal function; abnormal ER stress contributes to diabetes…”
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Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease by McCoy, Melissa K, Martinez, Terina N, Ruhn, Kelly A, Szymkowski, David E, Smith, Christine G, Botterman, Barry R, Tansey, Keith E, Tansey, Malu G

“…The mechanisms that trigger or contribute to loss of dopaminergic (DA) neurons in Parkinson's disease (PD) remain unclear and controversial. Elevated levels of…”
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TNF: a key neuroinflammatory mediator of neurotoxicity and neurodegeneration in models of Parkinson's disease by McCoy, Melissa K, Ruhn, Kelly A, Blesch, Armin, Tansey, Malú G

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GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology by DiCesare, Sophia M, Ortega, Antonio J, Collier, Gracen E, Daniel, Steffi, Thompson, Krista N, McCoy, Melissa K, Posner, Bruce A, Hulleman, John D

“…Malattia Leventinese/Doyne honeycomb retinal dystrophy (ML/DHRD) is an age-related macular degeneration-like (AMD-like) retinal dystrophy caused by an…”
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Regulator of G-Protein Signaling 10 Promotes Dopaminergic Neuron Survival via Regulation of the Microglial Inflammatory Response by Lee, Jae-Kyung, McCoy, Melissa K, Harms, Ashley S, Ruhn, Kelly A, Gold, Stephen J, Tansey, Malu G

“…Epidemiological studies suggest that chronic use of nonsteroidal anti-inflammatory drugs lowers the incidence of Parkinson's disease (PD) in humans and…”
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Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy? by Tansey, Malú G, Frank-Cannon, Tamy C, McCoy, Melissa K, Lee, Jae Kyung, Martinez, Terina N, McAlpine, Fiona E, Ruhn, Kelly A, Tran, Thi A

“…The inflammatory response in the brain associated with most chronic neurodegenerative diseases is termed neuroinflammation. Neuropathological and…”
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Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β‑Cell Glucose-Sensing Pathways by Kalwat, Michael A, Wichaidit, Chonlarat, Nava Garcia, Alejandra Y, McCoy, Melissa K, McGlynn, Kathleen, Hwang, In Hyun, MacMillan, John B, Posner, Bruce A, Cobb, Melanie H

“…High throughput screening of insulin secretion is intractable with current methods. We developed a secreted insulin–luciferase system (Ins-GLuc) in β cells…”
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Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β‑Cell Glucose-Sensing Pathways by Kalwat, Michael A, Wichaidit, Chonlarat, Nava Garcia, Alejandra Y, McCoy, Melissa K, McGlynn, Kathleen, Hwang, In Hyun, MacMillan, John B, Posner, Bruce A, Cobb, Melanie H

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Messenger RNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex by Dillman, Allissa A., Hauser, David N., Gibbs, J. Raphael, Nalls, Michael A., McCoy, Melissa K., Rudenko, Iakov N., Galter, Dagmar, Cookson, Mark R.

“…The complexity of the adult brain is a result of both developmental processes and experience-dependent circuit formation. One way to look at the differences…”
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Regulator of G‐protein signaling (RGS10) regulates microglial response to chronic inflammatory stimuli and impacts dopaminergic neuron survival by Lee, Jae Kyung, McCoy, Melissa K, Harms, Ashley S, Ruhn, Kelly A, Gold, Stephen J, Tansey, Malu G

“…Abstract only Epidemiological studies suggest that chronic use of non‐steroidal anti‐inflammatory drugs (NSAIDs) lowers the incidence of Parkinson's disease…”
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