Search Results - "McCoy, Jay R."

DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response by Smith, Trevor Rf, Schultheis, Katherine, Kiosses, William B, Amante, Dinah H, Mendoza, Janess M, Stone, John C, McCoy, Jay R, Sardesai, Niranjan Y, Broderick, Kate E

“…The immunocompetence and clinical accessibility of dermal tissue offers an appropriate and attractive target for vaccination. We previously demonstrated that…”
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Piezoelectric permeabilization of mammalian dermal tissue for in vivo DNA delivery leads to enhanced protein expression and increased immunogenicity by Broderick, Kate E., Kardos, Thomas, McCoy, Jay R., Fons, Michael P., Kemmerrer, Stephen, Sardesai, Niranjan Y.

“…Electropermeabilization of mammalian cells is a technique that has been used for the delivery of therapeutics, such as DNA plasmids or DNA vaccines. Typically,…”
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Development of an intradermal DNA vaccine delivery strategy to achieve single-dose immunity against respiratory syncytial virus by Smith, Trevor R.F, Schultheis, Katherine, Morrow, Matthew P, Kraynyak, Kimberly A, McCoy, Jay R, Yim, Kevin C, Muthumani, Karuppiah, Humeau, Laurent, Weiner, David B, Sardesai, Niranjan Y, Broderick, Kate E

“…Highlights • Delineation of a DNA-based RSV vaccine delivery strategy targeting the epidermis. • Elicitation of robust immune responses after vaccine delivery…”
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A novel prototype device for electroporation-enhanced DNA vaccine delivery simultaneously to both skin and muscle by Lin, Feng, Shen, Xuefei, McCoy, Jay R, Mendoza, Janess M, Yan, Jian, Kemmerrer, Steve V, Khan, Amir S, Weiner, David B, Broderick, Kate E, Sardesai, Niranjan Y

“…Abstract Electroporation (EP) of either muscle or skin has proven to be an efficient method for increasing DNA-based vaccine delivery and immunogenicity in…”
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Skin Transfection Patterns and Expression Kinetics of Electroporation-Enhanced Plasmid Delivery Using the CELLECTRA-3P, a Portable Next-Generation Dermal Electroporation Device by Amante, Dinah H, Smith, Trevor R F, Mendoza, Janess M, Schultheis, Katherine, McCoy, Jay R, Khan, Amir S, Sardesai, Niranjan Y, Broderick, Kate E

“…The CELLECTRA-3P dermal electroporation device (Inovio Pharmaceuticals, Plymouth Meeting, PA) has been evaluated in the clinic and shown to enhance the…”
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Electroporation mediated DNA vaccination directly to a mucosal surface results in improved immune responses by Kichaev, Gleb, Mendoza, Janess M, Amante, Dinah, Smith, Trevor RF, McCoy, Jay R, Sardesai, Niranjan Y, Broderick, Kate E

“…In vivo electroporation (EP) has been shown to be a highly efficient non-viral method for enhancing DNA vaccine delivery and immunogenicity, when the site of…”
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A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin by McCoy, Jay R, Mendoza, Janess M, Spik, Kristin W, Badger, Catherine, Gomez, Alan F, Schmaljohn, Connie S, Sardesai, Niranjan Y, Broderick, Kate E

“…The identification of an effective and tolerable delivery method is a necessity for the success of DNA vaccines in the clinic. This article describes the…”
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A multi-head intradermal electroporation device allows for tailored and increased dose DNA vaccine delivery to the skin by McCoy, Jay R, Mendoza, Janess M, Spik, Kristin W, Badger, Catherine, Gomez, Alan F, Schmaljohn, Connie S, Sardesai, Niranjan Y, Broderick, Kate E

“…The identification of an effective and tolerable delivery method is a necessity for the success of DNA vaccines in the clinic. This manuscript describes the…”
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