Search Results - "McCoy, Ciaran J"

Global analysis of neuropeptide receptor conservation across phylum Nematoda by Golinelli, Luca, Geens, Ellen, Irvine, Allister, McCoy, Ciaran J, Vandewyer, Elke, Atkinson, Louise E, Mousley, Angela, Temmerman, Liesbet, Beets, Isabel

“…The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs)…”
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EAT-18 is an essential auxiliary protein interacting with the non-alpha nAChR subunit EAT-2 to form a functional receptor by Choudhary, Shivani, Buxton, Samuel K, Puttachary, Sreekanth, Verma, Saurabh, Mair, Gunnar R, McCoy, Ciaran J, Reaves, Barbara J, Wolstenholme, Adrian J, Martin, Richard J, Robertson, Alan P

“…Nematode parasites infect approximately 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more…”
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Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release by McCoy, Ciaran J, Reaves, Barbara J, Giguère, Steeve, Coates, Ruby, Rada, Balázs, Wolstenholme, Adrian J

“…Wuchereria bancrofti, Brugia malayi and Brugia timori infect over 100 million people worldwide and are the causative agents of lymphatic filariasis. Some…”
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Pan-phylum In Silico Analyses of Nematode Endocannabinoid Signalling Systems Highlight Novel Opportunities for Parasite Drug Target Discovery by Crooks, Bethany A., Mckenzie, Darrin, Cadd, Luke C., McCoy, Ciaran J., McVeigh, Paul, Marks, Nikki J., Maule, Aaron G., Mousley, Angela, Atkinson, Louise E.

“…The endocannabinoid signalling (ECS) system is a complex lipid signalling pathway that modulates diverse physiological processes in both vertebrate and…”
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Phylum-Spanning Neuropeptide GPCR Identification and Prioritization: Shaping Drug Target Discovery Pipelines for Nematode Parasite Control by Atkinson, Louise E, McCoy, Ciaran J, Crooks, Bethany A, McKay, Fiona M, McVeigh, Paul, McKenzie, Darrin, Irvine, Allister, Harrington, John, Rosa, Bruce A, Mitreva, Makedonka, Marks, Nikki J, Maule, Aaron G, Mousley, Angela

“…Nematode parasites undermine human health and global food security. The frontline anthelmintic portfolio used to treat parasitic nematodes is threatened by the…”
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Evaluation of changes in drug susceptibility and population genetic structure in Haemonchus contortus following worm replacement as a means to reverse the impact of multiple-anthelmintic resistance on a sheep farm by George, Melissa M., Vatta, Adriano F., Howell, Sue B., Storey, Bob E., McCoy, Ciaran J., Wolstenholme, Adrian J., Redman, Elizabeth M., Gilleard, John S., Kaplan, Ray M.

“…A population of Haemonchus contortus that was highly resistant to benzimidazoles and avermectin/milbemycins with a subpopulation that was resistant to…”
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flp-32 Ligand/receptor silencing phenocopy faster plant pathogenic nematodes by Atkinson, Louise E, Stevenson, Michael, McCoy, Ciaran J, Marks, Nikki J, Fleming, Colin, Zamanian, Mostafa, Day, Tim A, Kimber, Michael J, Maule, Aaron G, Mousley, Angela

“…Restrictions on nematicide usage underscore the need for novel control strategies for plant pathogenic nematodes such as Globodera pallida (potato cyst…”
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Recognition and killing of Brugia malayi microfilariae by human immune cells is dependent on the parasite sample and is not altered by ivermectin treatment by Reaves, Barbara J., Wallis, Connor, McCoy, Ciaran J., Lorenz, W. Walter, Rada, Balazs, Wolstenholme, Adrian J.

“…Mass administration of macrocyclic lactones targets the transmission of the causative agents of lymphatic filariasis to their insect vectors by rapidly…”
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ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum by McCoy, Ciaran J, Paupelin-Vaucelle, Humbeline, Gorilak, Peter, Beneke, Tom, Varga, Vladimir, Gluenz, Eva

“…Unc-51-like kinase (ULK) family serine-threonine protein kinase homologues have been linked to the function of motile cilia in diverse species. Mutations in…”
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New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches by McCoy, Ciaran J., Atkinson, Louise E., Zamanian, Mostafa, McVeigh, Paul, Day, Tim A., Kimber, Michael J., Marks, Nikki J., Maule, Aaron G., Mousley, Angela

“…•We report the identification of flp and flp-GPCR gene homologues in parasitic nematodes.•We provide data to support re-evaluation of the number of flp-genes…”
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In silico analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodes by McKay, Fiona M., McCoy, Ciaran J., Crooks, Bethany, Marks, Nikki J., Maule, Aaron G., Atkinson, Louise E., Mousley, Angela

“…[Display omitted] •Parasites possess a reduced complement of Caenorhabditis elegans neuropeptide-like protein (NLP)-encoding genes.•Parasite NLP profiles are…”
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Novel integrated computational AMP discovery approaches highlight diversity in the helminth AMP repertoire by Irvine, Allister, McKenzie, Darrin, McCoy, Ciaran J, Graham, Robert L J, Graham, Ciaren, Huws, Sharon A, Atkinson, Louise E, Mousley, Angela

“…Antimicrobial Peptides (AMPs) are immune effectors that are key components of the invertebrate innate immune system providing protection against pathogenic…”
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Pharmacological profile of Ascaris suum ACR‐16, a new homomeric nicotinic acetylcholine receptor widely distributed in Ascaris tissues by Abongwa, Melanie, Buxton, Samuel K, Courtot, Elise, Charvet, Claude L, Neveu, Cédric, McCoy, Ciaran J, Verma, Saurabh, Robertson, Alan P, Martin, Richard J

“…Summary Background and Purpose Control of nematode parasite infections relies largely on anthelmintic drugs, several of which act on nicotinic ACh receptors…”
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How do the macrocyclic lactones kill filarial nematode larvae? by Wolstenholme, Adrian J., Maclean, Mary J., Coates, Ruby, McCoy, Ciaran J., Reaves, Barbara J.

“…The macrocyclic lactones (MLs) are one of the few classes of drug used in the control of the human filarial infections, onchocerciasis and lymphatic…”
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Tool-Driven Advances in Neuropeptide Research from a Nematode Parasite Perspective by McCoy, Ciaran J., Atkinson, Louise E., Robb, Emily, Marks, Nikki J., Maule, Aaron G., Mousley, Angela

“…Expanding ‘omics’ datasets for parasitic nematodes have accelerated the identification of putative drug targets derived from the nematode nervous system…”
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RNA interference in adult Ascaris suum – an opportunity for the development of a functional genomics platform that supports organism-, tissue- and cell-based biology in a nematode parasite by McCoy, Ciaran J., Warnock, Neil D., Atkinson, Louise E., Atcheson, Erwan, Martin, Richard J., Robertson, Alan P., Maule, Aaron G., Marks, Nikki J., Mousley, Angela

“…[Display omitted] •RNA interference (RNAi) is readily achievable in adult Ascaris suum.•RNAi is capable of spreading in adult A. suum.•Multiple A. suum…”
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Unraveling flp-11/flp-32 dichotomy in nematodes by Atkinson, Louise E., Miskelly, Iain R., Moffett, Christy L., McCoy, Ciaran J., Maule, Aaron G., Marks, Nikki J., Mousley, Angela

“…[Display omitted] •flp-11 expression pattern is restricted in Caenorhabditis elegans.•flp-11 expression is conserved and restricted across multiple…”
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