Search Results - "McCourt, Matthew"

Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody by Stewart, Ross, Morrow, Michelle, Hammond, Scott A, Mulgrew, Kathy, Marcus, Danielle, Poon, Edmund, Watkins, Amanda, Mullins, Stefanie, Chodorge, Matthieu, Andrews, John, Bannister, David, Dick, Emily, Crawford, Nicola, Parmentier, Julie, Alimzhanov, Marat, Babcook, John S, Foltz, Ian N, Buchanan, Andrew, Bedian, Vahe, Wilkinson, Robert W, McCourt, Matthew

“…Programmed cell-death 1 ligand 1 (PD-L1) is a member of the B7/CD28 family of proteins that control T-cell activation. Many tumors can upregulate expression of…”
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Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery by Mosely, Suzanne I S, Prime, John E, Sainson, Richard C A, Koopmann, Jens-Oliver, Wang, Dennis Y Q, Greenawalt, Danielle M, Ahdesmaki, Miika J, Leyland, Rebecca, Mullins, Stefanie, Pacelli, Luciano, Marcus, Danielle, Anderton, Judith, Watkins, Amanda, Coates Ulrichsen, Jane, Brohawn, Philip, Higgs, Brandon W, McCourt, Matthew, Jones, Hazel, Harper, James A, Morrow, Michelle, Valge-Archer, Viia, Stewart, Ross, Dovedi, Simon J, Wilkinson, Robert W

“…Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these models are still not…”
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Valuing the diverse economies and climate possibilities of a winter festival in Western Maine, USA by McCourt, Matthew, Perkins, Gabriel

“…A group of citizens in western Maine was recently galvanized by their shared, volunteer labor of preparing a course for a major regional ski race during a low…”
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cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions by Grütter, Christian, Wilkinson, Trevor, Turner, Richard, Podichetty, Sadhana, Finch, Donna, McCourt, Matthew, Loning, Scott, Jermutus, Lutz, Grütter, Markus G

“…TGF-β isoforms are key modulators of a broad range of biological pathways and increasingly are exploited as therapeutic targets. Here, we describe the crystal…”
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Preclinical and Clinical Studies of MMP Inhibitors in Cancer by DRUMMOND, ALAN H., BECKETT, PAUL, BROWN, PETER D., BONE, ELISABETH A., DAVIDSON, ALAN H., GALLOWAY, W. ALAN, GEARING, ANDY J.H., HUXLEY, PHIL, LABER, DAVID, MCCOURT, MATTHEW, WHITTAKER, MARK, WOOD, L. MICHAEL, WRIGHT, ANNETTE

“…The role of matrix metalloproteinases in tumor angiogenesis and growth is now well recognized for models of both human and animal cancer. Clinical studies…”
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Abstract 4953: Differential expression of ICOS on circulating immune cells and tumor infiltrating lymphocytes in patient with solid tumors by Sainson, Richard C., Kosmac, Miha, Kimber, Rachael, Carvalho, Joana, Bohris, Gwenoline, Thotakura, Anil, Melvin, David, McCourt, Matthew

“…Abstract Background: The Inducible T-cell costimulator (ICOS/CD278) is upregulated during T cell activation and is an important regulator of the immune…”
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Th1 cytokines are more effective than Th2 cytokines at licensing anti‐tumour functions in CD40‐activated human macrophages in vitro by Luheshi, Nadia, Davies, Gareth, Poon, Edmund, Wiggins, Kimberley, McCourt, Matthew, Legg, James

“…CD40 agonists are showing activity in early clinical trials in patients with advanced cancer. In animal models, CD40 agonists synergise with T‐cell‐activating…”
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Abstract LB-153: KY1055, a novel ICOS-PD-L1 bispecific antibody, efficiently enhances T cell activation and delivers a potent anti-tumour response in vivo by Sainson, Richard C., Parveen, Nahida, Borhis, Gwenoline, Kosmac, Miha, OKell, Tracey, Taggart, Emma, Carvalho, Joana, McCourt, Matthew, Ali, Hanif, Craig, Hannah, Labokha, Aksana

“…Abstract Antibodies blocking the PD-1/PD-L1 axis present significant breakthroughs in the treatment of hitherto untreatable cancers. However, despite the…”
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A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension by Arnold, Nadine D., Pickworth, Josephine A., West, Laura E., Dawson, Sarah, Carvalho, Joana A., Casbolt, Helen, Braithwaite, Adam T., Iremonger, James, Renshall, Lewis, Germaschewski, Volker, McCourt, Matthew, Bland-Ward, Philip, Kowash, Hager, Hameed, Abdul G., Rothman, Alexander M. K., Frid, Maria G., Roger Thompson, A. A., Evans, Holly R., Southwood, Mark, Morrell, Nicholas W., Crossman, David C., Whyte, Moira K. B., Stenmark, Kurt R., Newman, Christopher M., Kiely, David G., Francis, Sheila E., Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive…”
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Abstract 2792: The combination of immune checkpoint blockers with the anti-ICOS KY1044 antibody results in a strong tumor response by Sainson, Richard C., McCourt, Matthew, Thotakura, Anil, Parveen, Nahida, Kismac, Miha, Borhis, Gwenoline, Carvalho, Joana, Myers, Tracey, Rowlands, Robert, Ali, Hanif, Craig, Hannah, Wong, Vivian, Liang, Qi, Germaschewski, Volker

“…Abstract The last few years have shown a strong paradigm shift in cancer therapies with the approval of antibodies targeting immune checkpoints (CTLA-4, PD-1…”
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Placing E Pluribus Unum on the Indianapolis Cultural Trail by Owen Dwyer, Matthew McCourt

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T h1 cytokines are more effective than T h2 cytokines at licensing anti‐tumour functions in CD 40‐activated human macrophages in vitro by Luheshi, Nadia, Davies, Gareth, Poon, Edmund, Wiggins, Kimberley, McCourt, Matthew, Legg, James

“…CD 40 agonists are showing activity in early clinical trials in patients with advanced cancer. In animal models, CD 40 agonists synergise with T…”
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Abstract 1542: Th1 and Th2 cytokines determine how CD40 activation changes human macrophage function in vitro by Luheshi, Nadia, Davies, Gareth C., Poon, Edd, McCourt, Matthew, Legg, James W.

“…Abstract Tumour associated macrophages (TAM) often adopt an M2-like immunosuppressive phenotype, promoting tumour growth and metastasis. However, TAM display…”
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Abstract 1562: Choosing the right preclinical model for cancer immunotherapy: The “SyngenOmic” toolbox by Harper, James A., Prime, John, Herath, Athula, Howell, Jane, Papaspyridonos, Marianna, Popple, Amy, Anderton, Judith, Morrow, Michelle, Lewis, Arthur, Henley, Liz, McCourt, Matthew, Sainson, Richard

“…Abstract Recent FDA approvals of ipilimumab and sipuleucel-T for the treatment of metastatic melanoma and castrate-resistant prostate cancer respectively have…”
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Abstract 1616: Survivin regulates endothelial cell proliferation, survival and angiogenesis by Eberlein, Cath, Opoku-Ansah, Grace, Legg, James, London, Tim, Gebhardt, Frank, Davies, Gareth, Tigue, Natalie, McCourt, Matthew, White, Julia, Cross, Darren, Schaeper, Ute, Valge-Archer, Viia E.

“…Abstract Background - Survivin is a member of the inhibitor of apoptosis protein (IAP) family, and is reported to be overexpressed in a number of human cancers…”
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Abstract 363: Activin receptor-like kinase 1 (Alk1) ligands modulate endothelial cell function in vitro and in vivo by Davies, Gareth C., Harper, James A., Sainson, Richard C., Brown, Lee, Opoku-Ansah, Grace, Smith, Alison, McCourt, Matthew, Legg, James W.

“…Abstract The TGF-ß type-1 receptor activin receptor-like kinase 1 (Alk1) is predominantly expressed on endothelial cells, regulates vascular morphogenesis, and…”
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Improved drug-like properties of therapeutic proteins by directed evolution by Buchanan, Andrew, Ferraro, Franco, Rust, Steven, Sridharan, Sudharsan, Franks, Ruth, Dean, Greg, McCourt, Matthew, Jermutus, Lutz, Minter, Ralph

“…Many natural human proteins have functional properties that make them useful as therapeutic drugs. However, not all these proteins are compatible with…”
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Combining TGF-β inhibition and angiotensin II blockade results in enhanced antifibrotic effect by Yu, Ling, Border, Wayne A., Anderson, Ian, Mccourt, Matthew, Huang, Yufeng, Noble, Nancy A.

“…Combining TGF-β inhibition and angiotensin II blockade results in enhanced antifibrotic effects. Although angiotensin II (Ang II) blockade is rapidly becoming…”
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Making Memory, Making Landscapes: Classroom Applications of Parallel Trends in the Study of Landscape, Memory, and Learning by DWYER, OWEN J., MCCOURT, MATTHEW

“…New approaches to cultural landscape have encouraged a widened range of encounters with the relationship between memory and landscape. At the same time,…”
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Abstract LB-158: MEDI4736: Delivering effective blockade of immunosupression to enhance tumour rejection: Monoclonal antibody discovery and preclinical development by Stewart, Ross A., Morrow, Michelle, Chodorge, Matthieu, Marcus, Danielle, Boyle, Melanie, Mulgrew, Kathy, Hammond, Scott, Wang, Suping, Alimzhanov, Marat, Robbins, Paul, Lanning, Karen, Bedian, Vahe, McCourt, Matthew, Lo, Mathew

“…Abstract Cancerous cells emerge within the body following accumulation of deleterious genetic mutations. These mutations alter the phenotype of a cancer cell…”
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