Search Results - "McCool, Elijah N"

Recent advances (2019–2021) of capillary electrophoresis‐mass spectrometry for multilevel proteomics by Chen, Daoyang, McCool, Elijah N., Yang, Zhichang, Shen, Xiaojing, Lubeckyj, Rachele A., Xu, Tian, Wang, Qianjie, Sun, Liangliang

“…Multilevel proteomics aims to delineate proteins at the peptide (bottom‐up proteomics), proteoform (top‐down proteomics), and protein complex (native…”
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Capillary zone electrophoresis-mass spectrometry for top-down proteomics by Shen, Xiaojing, Yang, Zhichang, McCool, Elijah N., Lubeckyj, Rachele A., Chen, Daoyang, Sun, Liangliang

“…Mass spectrometry (MS)-based top-down proteomics characterizes complex proteomes at the intact proteoform level and provides an accurate picture of protein…”
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Single-Shot Top-Down Proteomics with Capillary Zone Electrophoresis-Electrospray Ionization-Tandem Mass Spectrometry for Identification of Nearly 600 Escherichia coli Proteoforms by Lubeckyj, Rachele A, McCool, Elijah N, Shen, Xiaojing, Kou, Qiang, Liu, Xiaowen, Sun, Liangliang

“…Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry (CZE-ESI-MS/MS) has been recognized as an invaluable platform for top-down…”
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Deep Top-Down Proteomics Using Capillary Zone Electrophoresis-Tandem Mass Spectrometry: Identification of 5700 Proteoforms from the Escherichia coli Proteome by McCool, Elijah N, Lubeckyj, Rachele A, Shen, Xiaojing, Chen, Daoyang, Kou, Qiang, Liu, Xiaowen, Sun, Liangliang

“…Capillary zone electrophoresis (CZE)-tandem mass spectrometry (MS/MS) has been recognized as a useful tool for top-down proteomics. However, its performance…”
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Evaluation of Machine Learning Models for Proteoform Retention and Migration Time Prediction in Top-Down Mass Spectrometry by Chen, Wenrong, McCool, Elijah N., Sun, Liangliang, Zang, Yong, Ning, Xia, Liu, Xiaowen

“…Reversed-phase liquid chromatography (RPLC) and capillary zone electrophoresis (CZE) are two primary proteoform separation methods in mass spectrometry…”
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Automated Capillary Isoelectric Focusing-Tandem Mass Spectrometry for Qualitative and Quantitative Top-Down Proteomics by Xu, Tian, Shen, Xiaojing, Yang, Zhichang, Chen, Daoyang, Lubeckyj, Rachele A, McCool, Elijah N, Sun, Liangliang

“…Top-down proteomics (TDP) aims to delineate proteomes in a proteoform-specific manner, which is vital for accurately understanding protein function in cellular…”
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Predicting Electrophoretic Mobility of Proteoforms for Large-Scale Top-Down Proteomics by Chen, Daoyang, Lubeckyj, Rachele A, Yang, Zhichang, McCool, Elijah N, Shen, Xiaojing, Wang, Qianjie, Xu, Tian, Sun, Liangliang

“…Large-scale top-down proteomics characterizes proteoforms in cells globally with high confidence and high throughput using reversed-phase liquid chromatography…”
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Capillary zone electrophoresis-tandem mass spectrometry for top-down proteomics using attapulgite nanoparticles functionalized separation capillaries by Wang, Tingting, Chen, Daoyang, Lubeckyj, Rachele A., Shen, Xiaojing, Yang, Zhichang, McCool, Elijah N., Qiao, Xiaoqiang, Sun, Liangliang

“…Attapulgite nanoparticles have good chemical properties and can be modified easily for broad applications. In this work, for the first time, attapulgite…”
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Capillary Zone Electrophoresis-Tandem Mass Spectrometry with Activated Ion Electron Transfer Dissociation for Large-scale Top-down Proteomics by McCool, Elijah N., Lodge, Jean M., Basharat, Abdul Rehman, Liu, Xiaowen, Coon, Joshua J., Sun, Liangliang

“…Capillary zone electrophoresis (CZE)-tandem mass spectrometry (MS/MS) has been recognized as an efficient approach for top-down proteomics recently for its…”
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Deep top-down proteomics revealed significant proteoform-level differences between metastatic and nonmetastatic colorectal cancer cells by McCool, Elijah N, Xu, Tian, Chen, Wenrong, Beller, Nicole C, Nolan, Scott M, Hummon, Amanda B, Liu, Xiaowen, Sun, Liangliang

“…Understanding cancer metastasis at the proteoform level is crucial for discovering previously unknown protein biomarkers for cancer diagnosis and drug…”
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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry by McCool, Elijah N, Lubeckyj, Rachele, Shen, Xiaojing, Kou, Qiang, Liu, Xiaowen, Sun, Liangliang

“…Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry (CZE-ESI-MS/MS) has been recognized as a useful tool for top-down proteomics…”
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The “PepSAVI-MS” Pipeline for Natural Product Bioactive Peptide Discovery by Kirkpatrick, Christine L, Broberg, Christopher A, McCool, Elijah N, Lee, Woo Jean, Chao, Alex, McConnell, Evan W, Pritchard, David A, Hebert, Michael, Fleeman, Renee, Adams, Jessie, Jamil, Amer, Madera, Laurence, Strömstedt, Adam A, Göransson, Ulf, Liu, Yufeng, Hoskin, David W, Shaw, Lindsey N, Hicks, Leslie M

“…The recent increase in extensively drug-resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for…”
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Recent advances (2019-2021) of capillary electrophoresis-mass spectrometry for multi-level proteomics by Chen, Daoyang, McCool, Elijah N., Yang, Zhichang, Shen, Xiaojing, Lubeckyj, Rachele A., Xu, Tian, Wang, Qianjie, Sun, Liangliang

“…Multi-level proteomics aims to delineate proteins at the peptide (bottom-up proteomics), proteoform (top-down proteomics), and protein complex (native…”
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Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry by McCool, Elijah N., Lubeckyj, Rachele, Shen, Xiaojing, Kou, Qiang, Liu, Xiaowen, Sun, Liangliang

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Capillary Zone Electrophoresis-Tandem Mass Spectrometry with Activated Ion Electron Transfer Dissociation for Large-scale Top-down Proteomics by McCool, Elijah N, Lodge, Jean M, Basharat, Abdul Rehman, Liu, Xiaowen, Coon, Joshua J, Sun, Liangliang

“…Capillary zone electrophoresis (CZE)-tandem mass spectrometry (MS/MS) has been recognized as an efficient approach for top-down proteomics recently for its…”
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