Search Results - "McConnell, John D"

Association of the Circulating Levels of the Urokinase System of Plasminogen Activation With the Presence of Prostate Cancer and Invasion, Progression, and Metastasis by SHARIAT, Shahrokh F, ROEHRBORN, Claus G, MCCONNELL, John D, PARK, Sangtae, ALAM, Nina, WHEELER, Thomas M, SLAWIN, Kevin M

“…To assess whether preoperative plasma levels of urokinase-type plasminogen activator (uPA) and its soluble receptor (uPAR) would predict cancer of the prostate…”
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Biopsy Misidentification Identified by DNA Profiling in a Large Multicenter Trial by Marberger, Michael, McConnell, John D, Fowler, Ivy, Andriole, Gerald L, Bostwick, David G, Somerville, Matthew C, Rittmaster, Roger S

“…The Reduction by Dutasteride of Prostate Cancer Events (REDUCE) prostate cancer risk reduction study randomly assigned 8,231 men to dutasteride or placebo for…”
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Prostate cancer disease-free survival after radical retropubic prostatectomy in patients older than 70 years compared to younger cohorts by Malaeb, Bahaa S., M.D, Rashid, Hani H., M.D, Lotan, Yair, M.D, Khoddami, Seyyed M., M.D, Shariat, Shahrokh F., M.D, Sagalowsky, Arthur I., M.D, McConnell, John D., M.D, Roehrborn, Claus G., M.D, Koeneman, Kenneth S., M.D

“…Abstract Objectives To evaluate the feasibility of radical retropubic prostatectomy (RRP) as an option for treating men older than 70 years with organ confined…”
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The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia by McConnell, John D, Roehrborn, Claus G, Bautista, Oliver M, Andriole, Gerald L, Dixon, Christopher M, Kusek, John W, Lepor, Herbert, McVary, Kevin T, Nyberg, Leroy M, Clarke, Harry S, Crawford, E. David, Diokno, Ananias, Foley, John P, Foster, Harris E, Jacobs, Stephen C, Kaplan, Steven A, Kreder, Karl J, Lieber, Michael M, Lucia, M. Scott, Miller, Gary J, Menon, Mani, Milam, Douglas F, Ramsdell, Joe W, Schenkman, Noah S, Slawin, Kevin M, Smith, Joseph A

“…In this long-term trial, the combination of an alpha-blocker (doxazosin) and a 5α-reductase inhibitor (finasteride) was superior to either drug alone in…”
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Potential Impact of Adding Genetic Markers to Clinical Parameters in Predicting Prostate Biopsy Outcomes in Men Following an Initial Negative Biopsy: Findings from the REDUCE Trial by Kader, A. Karim, Sun, Jielin, Reck, Brian H, Newcombe, Paul J, Kim, Seong-Tae, Hsu, Fang-Chi, D’Agostino, Ralph B, Tao, Sha, Zhang, Zheng, Turner, Aubrey R, Platek, Greg T, Spraggs, Colin F, Whittaker, John C, Lane, Brian R, Isaacs, William B, Meyers, Deborah A, Bleecker, Eugene R, Torti, Frank M, Trent, Jeffery M, McConnell, John D, Zheng, S. Lilly, Condreay, Lynn D, Rittmaster, Roger S, Xu, Jianfeng

“…Abstract Background Several germline single nucleotide polymorphisms (SNPs) have been consistently associated with prostate cancer (PCa) risk. Objective To…”
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Combination therapy with doxazosin and finasteride for benign prostatic hyperplasia in patients with lower urinary tract symptoms and a baseline total prostate volume of 25 ml or greater by Kaplan, Steven A, McConnell, John D, Roehrborn, Claus G, Meehan, Alan G, Lee, Michael W, Noble, William R, Kusek, John W, Nyberg, Jr, Leroy M

“…We examined data from the Medical Therapy of Prostatic Symptoms trial to determine the relationship between baseline TPV and the effect of medical therapy in…”
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Baseline factors as predictors of clinical progression of benign prostatic hyperplasia in men treated with placebo by Crawford, E David, Wilson, Shandra S, McConnell, John D, Slawin, Kevin M, Lieber, Michael C, Smith, Joseph A, Meehan, Alan G, Bautista, Oliver M, Noble, William R, Kusek, John W, Nyberg, Leroy M, Roehrborn, Claus G

“…We analyzed data from the placebo arm of the MTOPS trial to determine clinical predictors of BPH progression. A total of 3,047 patients with LUTS were…”
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Long-term treatment with finasteride results in a clinically significant reduction in total prostate volume compared to placebo over the full range of baseline prostate sizes in men enrolled in the MTOPS trial by Kaplan, Steven A, Roehrborn, Claus G, McConnell, John D, Meehan, Alan G, Surynawanshi, Shailaja, Lee, Jeannette Y, Rotonda, Jennifer, Kusek, John W, Nyberg, Jr, Leroy M

“…In the present analysis we examined data from the MTOPS (Medical Therapy of Prostatic Symptoms) trial to determine the effect of long-term finasteride…”
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The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment among Men with Benign Prostatic Hyperplasia by McConnell, John D, Bruskewitz, Reginald, Walsh, Patrick, Andriole, Gerald, Lieber, Michael, Holtgrewe, H. Logan, Albertsen, Peter, Roehrborn, Claus G, Nickel, J. Curtis, Wang, Daniel Z, Taylor, Alice M, Waldstreicher, Joanne

“…Benign prostatic hyperplasia is common among older men, and its symptoms interfere with normal activities and reduce the sense of well-being. 1 It can also be…”
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Factors influencing the outcomes of penile prosthesis surgery at a teaching institution by Lotan, Yair, Roehrborn, Claus G, McConnell, John D, Hendin, Benjamin N

“…To evaluate the long-term outcomes of penile prosthesis surgery at a teaching institution. Patients who had penile prosthesis surgery from 1988 to 1999 at a…”
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The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 by Wang, Zhi, Tseng, Ching-Ping, Pong, Rey-Chen, Chen, Hong, McConnell, John D, Navone, Nora, Hsieh, Jer-Tsong

“…DOC-2/DAB2 is a member of the disable gene family with tumor-inhibitory activity. Its down-regulation is associated with several neoplasms, and serine…”
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Surrogate marker for predicting the virus binding of urogenital cancer cells during adenovirus-based gene therapy by Lai, Yun-Jun, Pong, Rey-Chen, McConnell, John D, Hsieh, Jer-Tsong

“…Virus uptake is the first rate-limiting step for the successful gene delivery of any virus-based gene therapy. For adenovirus-based gene therapy, the…”
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Lymphovascular invasion is a pathological feature of biologically aggressive disease in patients treated with radical prostatectomy by Shariat, Shahrokh F, Khoddami, Seyed M, Saboorian, Hossein, Koeneman, Kenneth S, Sagalowsky, Arthur I, Cadeddu, Jeffrey A, McConnell, John D, Holmes, Marisa N, Roehrborn, Claus G

“…We examined whether invasion of lymphatic and/or vascular vessels (LVI), or perineural spaces (PNI) is associated with prostate cancer features and outcome. A…”
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Serum prostate-specific antigen concentration is a powerful predictor of acute urinary retention and need for surgery in men with clinical benign prostatic hyperplasia by Roehrborn, Claus G, McConnell, John D, Lieber, Michael, Kaplan, Steven, Geller, Jack, Malek, Gholem H, Castellanos, Ronald, Coffield, Scott, Saltzman, Brian, Resnick, Martin, Cook, Thomas J, Waldstreicher, Joanne

“…Objectives. Prostate-specific antigen (PSA) is produced exclusively in the prostate gland and is currently the most useful clinical marker for the detection of…”
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Long-term 6-year experience with finasteride in patients with benign prostatic hyperplasia by Lowe, Franklin C, McConnell, John D, Hudson, Perry B, Romas, Nicholas A, Boake, Rex, Lieber, Michael, Elhilali, Mostafa, Geller, Jack, Imperto-McGinely, Juliane, Andriole, Gerald L, Bruskewitz, Reginald C, Walsh, Patrick C, Bartsch, Georg, Nacey, John N, Shah, Sukrut, Pappas, Frances, Ko, Amy, Cook, Thomas, Stoner, Elizabeth, Waldstreicher, Joanne

“…To summarize the 6-year clinical trial data with finasteride. Benign prostatic hyperplasia is a chronic and progressive disease and therefore assessment of…”
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Sustained decrease in incidence of acute urinary retention and surgery with finasteride for 6 years in men with benign prostatic hyperplasia by Roehrborn, Claus G, Bruskewitz, Reginald, Nickel, J Curtis, McConnell, John D, Saltzman, Brian, Gittelman, Marc C, Malek, Gholem H, Gottesman, James E, Suryawanshi, Shilaja, Drisko, Jennifer, Meehan, Alan, Waldstreicher, Joanne

“…We determined the effect of long-term treatment with finasteride on the incidence of acute urinary retention (AUR) and benign prostatic hyperplasia (BPH)…”
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The Effect of Finasteride in Men with Benign Prostatic Hyperplasia by Gormley, Glenn J, Stoner, Elizabeth, Bruskewitz, Reginald C, Imperato-McGinley, Julianne, Walsh, Patrick C, McConnell, John D, Andriole, Gerald L, Geller, Jack, Bracken, Bruce R, Tenover, Joyce S, Vaughan, E. Darracott, Pappas, Frances, Taylor, Alice, Binkowitz, Bruce, Ng, Jennifer

“…BENIGN prostatic hyperplasia is common in aging men. The resulting enlargement of the prostate gland can lead to urethral obstruction and even complete urinary…”
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The percent of biopsy cores positive for cancer is a predictor of advanced pathological stage and poor clinical outcomes in patients treated with radical prostatectomy by Lotan, Yair, Shariat, Shahrokh F, Khoddami, Seyed M, Saboorian, Hossein, Koeneman, Kenneth S, Cadeddu, Jeffrey A, Sagalowsky, Arthur I, McConnell, John D, Roehrborn, Claus G

“…We examined if the percent of positive biopsies is associated with features of biologically aggressive prostate cancer, biochemical progression and development…”
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Storage (Irritative) and Voiding (Obstructive) Symptoms as Predictors of Benign Prostatic Hyperplasia Progression and Related Outcomes by Roehrborn, Claus G, McConnell, John D, Saltzman, Brian, Bergner, Donald, Gray, Todd, Narayan, Perinchery, Cook, Thomas J, Johnson-Levonas, Amy O, Quezada, Wilson A, Waldstreicher, Joanne

“…Objectives: To assess the utility of voiding and filling symptom subscores in predicting features of benign prostatic hyperplasia (BPH) progression, including…”
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Predictive value of primary Gleason pattern 4 in patients with Gleason score 7 tumours treated with radical prostatectomy by Khoddami, Seyed M., Shariat, Shahrokh F., Lotan, Yair, Saboorian, Hossein, McConnell, John D., Sagalowsky, Arthur I., Roehrborn, Claus G., Koeneman, Kenneth S.

“…OBJECTIVE To examine whether Gleason score (GS) 3 + 4 and 4 + 3 cancers at radical prostatectomy behave differently and whether this behaviour is independently…”
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