Search Results - "McConnell, James C"

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling by Eyre, Rachel, Alférez, Denis G., Santiago-Gómez, Angélica, Spence, Kath, McConnell, James C., Hart, Claire, Simões, Bruno M., Lefley, Diane, Tulotta, Claudia, Storer, Joanna, Gurney, Austin, Clarke, Noel, Brown, Mick, Howell, Sacha J., Sims, Andrew H., Farnie, Gillian, Ottewell, Penelope D., Clarke, Robert B.

“…Dissemination of tumour cells to the bone marrow is an early event in breast cancer, however cells may lie dormant for many years before bone metastases…”
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How stiff is skin? by Graham, Helen K., McConnell, James C., Limbert, Georges, Sherratt, Michael J.

“…The measurement of the mechanical properties of skin (such as stiffness, extensibility and strength) is a key step in characterisation of both dermal ageing…”
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Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs by Clarke, Louise E, McConnell, James C, Sherratt, Michael J, Derby, Brian, Richardson, Stephen M, Hoyland, Judith A

“…Currently, there is huge research focus on the development of novel cell-based regeneration and tissue-engineering therapies for the treatment of…”
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The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle by Keen, Adam N, Fenna, Andrew J, McConnell, James C, Sherratt, Michael J, Gardner, Peter, Shiels, Holly A

“…Chronic pressure or volume overload can cause the vertebrate heart to remodel. The hearts of fish remodel in response to seasonal temperature change. Here we…”
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Lysyl oxidase‐like 2 (LOXL2)‐mediated cross‐linking of tropoelastin by Schmelzer, Christian E. H., Heinz, Andrea, Troilo, Helen, Lockhart‐Cairns, Michael P., Jowitt, Thomas A., Marchand, Marion F., Bidault, Laurent, Bignon, Marine, Hedtke, Tobias, Barret, Alain, McConnell, James C., Sherratt, Michael J., Germain, Stéphane, Hulmes, David J. S., Baldock, Clair, Muller, Laurent

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Raised mammographic density: causative mechanisms and biological consequences by Sherratt, Michael J, McConnell, James C, Streuli, Charles H

“…High mammographic density is the most important risk factor for breast cancer, after ageing. However, the composition, architecture, and mechanical properties…”
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Lysyl oxidase‐like 2 (LOXL2)‐mediated cross‐linking of tropoelastin by Schmelzer, Christian E. H., Heinz, Andrea, Troilo, Helen, Lockhart‐Cairns, Michael P., Jowitt, Thomas A., Marchand, Marion F., Bidault, Laurent, Bignon, Marine, Hedtke, Tobias, Barret, Alain, McConnell, James C., Sherratt, Michael J., Germain, Stéphane, Hulmes, David J. S., Baldock, Clair, Muller, Laurent

“…ABSTRACTLysyl oxidases (LOXs) play a central role in extracellular matrix remodeling during development and tumor growth and fibrosis through cross‐linking of…”
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Increased peri-ductal collagen micro-organization may contribute to raised mammographic density by McConnell, James C, O'Connell, Oliver V, Brennan, Keith, Weiping, Lisa, Howe, Miles, Joseph, Leena, Knight, David, O'Cualain, Ronan, Lim, Yit, Leek, Angela, Waddington, Rachael, Rogan, Jane, Astley, Susan M, Gandhi, Ashu, Kirwan, Cliona C, Sherratt, Michael J, Streuli, Charles H

“…High mammographic density is a therapeutically modifiable risk factor for breast cancer. Although mammographic density is correlated with the relative…”
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Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles by PEARCE, Mark S, MCCONNELL, James C, POTTER, Catherine, BARRETT, Laura M, PARKER, Louise, MATHERS, John C, RELTON, Caroline L

“…Patterns of DNA methylation change with age and these changes are believed to be associated with the development of common complex diseases. The hypothesis…”
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Macro- and micromechanical remodelling in the fish atrium is associated with regulation of collagen 1 alpha 3 chain expression by Keen, Adam N., Fenna, Andrew J., McConnell, James C., Sherratt, Michael J., Gardner, Peter, Shiels, Holly A.

“…Numerous pathologies lead to remodelling of the mammalian ventricle, often associated with fibrosis. Recent work in fish has shown that fibrotic remodelling of…”
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Bioinformatic selection of putative epigenetically regulated loci associated with obesity using gene expression data by Turcot, Valérie, Groom, Alexandra, McConnell, James C., Pearce, Mark S., Potter, Catherine, Embleton, Nicholas D., Swan, Daniel C., Relton, Caroline L.

“…There is considerable interest in defining the relationship between epigenetic variation and the risk of common complex diseases. Strategies which assist in…”
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Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles by Pearce, M. S., McConnell, J. C., Potter, C., Barrett, L. M., Parker, L., Mathers, J. C., Relton, C. L.

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Abstract P4-04-14: High mammographic density is associated with deposition of organised fibrillar collagen and increased stiffness in periductal breast stroma by Gandhi, Ashu, Kirwan, Cliona C, McConnell, James C, O'Connell, Oliver V, Sherratt, Michael J, Streuli, Charles H

“…Abstract Introduction High mammographic density (MD) in women is strongly associated with breast cancer risk. However the structural and compositional…”
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Performance of rats alternately fed diets higher and lower in energy or protein by Barth, K M, McConnell, J C

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