Search Results - "McConkey, D."

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells by Zhu, K, Dunner, K, McConkey, D J

“…The ubiquitin-proteasome and lysosome-autophagy pathways are the two major intracellular protein degradation systems that work cooperatively to maintain…”
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Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials by Potts, B C, Albitar, M X, Anderson, K C, Baritaki, S, Berkers, C, Bonavida, B, Chandra, J, Chauhan, D, Cusack, Jr, J C, Fenical, W, Ghobrial, I M, Groll, M, Jensen, P R, Lam, K S, Lloyd, G K, McBride, W, McConkey, D J, Miller, C P, Neuteboom, S T C, Oki, Y, Ovaa, H, Pajonk, F, Richardson, P G, Roccaro, A M, Sloss, C M, Spear, M A, Valashi, E, Younes, A, Palladino, M A

“…The proteasome has emerged as an important clinically relevant target for the treatment of hematologic malignancies. Since the Food and Drug Administration…”
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Phase II trial of imatinib mesylate in patients with metastatic melanoma by Kim, K B, Eton, O, Davis, D W, Frazier, M L, McConkey, D J, Diwan, A H, Papadopoulos, N E, Bedikian, A Y, Camacho, L H, Ross, M I, Cormier, J N, Gershenwald, J E, Lee, J E, Mansfield, P F, Billings, L A, Ng, C S, Charnsangavej, C, Bar-Eli, M, Johnson, M M, Murgo, A J, Prieto, V G

“…Metastatic melanoma cells express a number of protein tyrosine kinases (PTKs) that are considered to be targets for imatinib. We conducted a phase II trial of…”
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PHP41 THE CHANGING LANDSCAPE OF ORPHAN DRUG PROVISION IN THE EU5 AND THE UNITED STATES by McConkey, D

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Epigenetic profiling demarcates molecular subtypes of muscle-invasive bladder cancer by van der Vos, K. E., Vis, D. J., Nevedomskaya, E., Kim, Y., Choi, W., McConkey, D., Wessels, L. F. A., van Rhijn, B. W. G., Zwart, W., van der Heijden, M. S.

“…Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease that often recurs despite aggressive treatment with neoadjuvant chemotherapy and (radical)…”
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Bcl-2 Expression Causes Redistribution of Glutathione to the Nucleus by Voehringer, D. W., McConkey, D. J., McDonnell, T. J., Brisbay, S., Meyn, R. E.

“…In this study we used HeLa cells transfected with a conditional Bcl-2 expression construct to study the effects of Bcl-2 on reduced glutathione (GSH)…”
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Biochemical determinants of apoptosis and necrosis by McConkey, David J

“…Although apoptosis and necrosis were originally thought to be entirely distinct mechanisms of cell death, recent work has shown that the processes are…”
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PA1 Assessing the Progression of the UK NHS Health Care Reforms and the Impact on Health Care Delivery by McConkey, D, White, R

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Epidermal Growth Factor Receptor Blockade with C225 Plus Gemcitabine Results in Regression of Human Pancreatic Carcinoma Growing Orthotopically in Nude Mice by Antiangiogenic Mechanisms by BRUNS, C. J, HARBISON, M. T, DAVIS, D. W, PORTERA, C. A, TSAN, R, MCCONKEY, D. J, EVANS, D. B, ABBRUZZESE, J. L, HICKLIN, D. J, RADINSKY, R

“…Both epidermal growth factor receptor (EGF-R) signaling mechanisms and angiogenesis have been evaluated as independent targets for therapy of human pancreatic…”
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Surrogate markers in antiangiogenesis clinical trials by DAVIS, D. W, MCCONKEY, D. J, ABBRUZZESE, J. L, HERBST, R. S

“…Novel antiangiogenic agents currently being developed may ultimately be more effective against solid tumours and less toxic than cytotoxic chemotherapy. As a…”
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Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells by MCCONKEY, D. J, YUN LIN, NUTT, L. K, OZEL, H. Z, NEWMAN, R. A

“…Cardiac glycosides are used clinically to increase contractile force in patients with cardiac disorders. Their mechanism of action is well established and…”
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Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine by CAREW, J. S, NAWROCKI, S. T, XU, R. H, DUNNER, K. JR, MCCONKEY, D. J, WIERDA, W. G, KEATING, M. J, HUANG, P

“…B cell chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in the Western hemisphere, yet many biological and molecular features of the…”
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Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis by SHAHEEN, R. M, DAVIS, D. W, WENBIAO LIU, ZEBROWSKI, B. K, WILSON, M. R, BUCANA, C. D, MCCONKEY, D. J, MCMAHON, G, ELLIS, L. M

“…Increased vascular endothelial growth factor (VEGF) expression is associated with colon cancer metastases. We hypothesized that inhibition of VEGF receptor…”
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Paclitaxel Enhances the Effects of the Anti-Epidermal Growth Factor Receptor Monoclonal Antibody ImClone C225 in Mice with Metastatic Human Bladder Transitional Cell Carcinoma by INOUE, Keiji, SLATON, Joel W, PERROTTE, Paul, DAVIS, Darren W, BRUNS, Christiane J, HICKLIN, Daniel J, MCCONKEY, David J, SWEENEY, Paul, RADINSKY, Robert, DINNEY, Colin P. N

“…Previously we reported that when cells from the human transitional cell carcinoma cell line 253J B-V growing orthotopically within the bladder of athymic nude…”
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PCN156 Value Based Pricing in the UK; Industry Stakeholders' Perspectives by Chate, S, Mcconkey, D, Mukku, S

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PRM19 Modelling the Impact of Multiple Indication Drug Launch on Total Revenue by McConkey, D, Wild, L

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Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis by YANO, Seiji, SHINOHARA, Hisashi, HERBST, Roy S, KUNIYASU, Hiroki, BUCANA, Corazon D, ELLIS, Lee M, DAVIS, Darren W, MCCONKEY, David J, FIDLER, Isaiah J

“…We investigated the molecular mechanisms of angiogenesis in experimental brain metastasis. Cells from six different human cancer cell lines (proven to produce…”
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Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases by Bruns, Christiane J., Liu, Wenbiao, Davis, Darren W., Shaheen, Raymond M., McConkey, David J., Wilson, Michael R., Bucana, Corazon D., Hicklin, Daniel J., Ellis, Lee M.

“…BACKGROUND Recent studies have suggested that vascular endothelial growth factor (VEGF), in addition to its proangiogenic properties, also functions as a…”
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The role of calcium in the regulation of apoptosis by McConkey, David J., Orrenius, Sten

“…The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegant to humans suggests that…”
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Histone Deacetylase Inhibitor Downregulation of bcl-xl Gene Expression Leads to Apoptotic Cell Death in Mesothelioma by Cao, Xiaobo X, Mohuiddin, Imran, Ece, Ferah, McConkey, David J, Smythe, W. Roy

“…It has been shown that mesothelioma expresses the antiapoptotic protein BCL-XL, but not BCL-2, rendering bcl-xl gene expression a potential therapeutic target…”
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