Search Results - "McConell, Glenn"

Muscle redox signalling pathways in exercise. Role of antioxidants by Mason, Shaun A., Morrison, Dale, McConell, Glenn K., Wadley, Glenn D.

“…Recent research highlights the importance of redox signalling pathway activation by contraction-induced reactive oxygen species (ROS) and nitric oxide (NO) in…”
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Exercise Increases Human Skeletal Muscle Insulin Sensitivity via Coordinated Increases in Microvascular Perfusion and Molecular Signaling by Sjøberg, Kim A, Frøsig, Christian, Kjøbsted, Rasmus, Sylow, Lykke, Kleinert, Maximilian, Betik, Andrew C, Shaw, Christopher S, Kiens, Bente, Wojtaszewski, Jørgen F P, Rattigan, Stephen, Richter, Erik A, McConell, Glenn K

“…Insulin resistance is a major health risk, and although exercise clearly improves skeletal muscle insulin sensitivity, the mechanisms are unclear. Here we show…”
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Normal increases in insulin-stimulated glucose uptake after ex vivo contraction in neuronal nitric oxide synthase mu (nNOSμ) knockout mice by Zhang, Xinmei, Lin, Xuzhu, McConell, Glenn K.

“…Nitric oxide (NO) is involved in skeletal muscle glucose uptake during exercise and also in the increase in insulin sensitivity after exercise. Given that…”
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Insulin‐induced membrane permeability to glucose in human muscles at rest and following exercise by McConell, Glenn K., Sjøberg, Kim A., Ceutz, Frederik, Gliemann, Lasse, Nyberg, Michael, Hellsten, Ylva, Frøsig, Christian, Kiens, Bente, Wojtaszewski, Jørgen F. P., Richter, Erik A.

“…Key points Increased insulin action is an important component of the health benefits of exercise, but its regulation is complex and not fully elucidated…”
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Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65% V̇O2peak in endurance trained men by McConell, Glenn K., Wadley, Glenn D., Le plastrier, Kieran, Linden, Kelly C.

“…Key points AMP‐activated protein kinase (AMPK) is considered a major regulator of skeletal muscle metabolism during exercise. However, we previously showed…”
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Lifelong physiology of a former marathon world-record holder: the pros and cons of extreme cardiac remodeling by Foulkes, Stephen J, Haykowsky, Mark J, Kistler, Peter M, McConell, Glenn K, Trappe, Scott, Hargreaves, Mark, Costill, David L, La Gerche, Andre

“…In a 77-year-old former world-record-holding male marathoner (2:08:33.6), this study sought to investigate the impact of lifelong intensive endurance exercise…”
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Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring by Falcão‐Tebas, Filippe, Marin, Evelyn C., Kuang, Jujiao, Bishop, David J., McConell, Glenn K.

“…Key points Paternal obesity negatively influences metabolic outcomes in adult rat offspring. Maternal voluntary physical activity has previously been reported…”
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Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content by Goodman, Craig A, Pol, Derk, Zacharewicz, Evelyn, Lee-Young, Robert S, Snow, Rod J, Russell, Aaron P, McConell, Glenn K

“…One serious side effect of statin drugs is skeletal muscle myopathy. Although the mechanism(s) responsible for statin myopathy remains to be fully determined,…”
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Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men by Trewin, Adam J, Levinger, Itamar, Parker, Lewan, Shaw, Christopher S, Serpiello, Fabio R, Anderson, Mitchell J, McConell, Glenn K, Hare, David L, Stepto, Nigel K

“…Obesity, sedentary lifestyle and aging are associated with mitochondrial dysfunction and impaired insulin sensitivity. Acute exercise increases insulin…”
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Passive stretch regulates skeletal muscle glucose uptake independent of nitric oxide synthase by Kerris, Jarrod P, Betik, Andrew C, Li, Jinhua, McConell, Glenn K

“…Skeletal muscle contraction increases glucose uptake via an insulin-independent mechanism. Signaling pathways arising from mechanical strain are activated…”
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No effect of acute beetroot juice ingestion on oxygen consumption, glucose kinetics, or skeletal muscle metabolism during submaximal exercise in males by Betteridge, Scott, Bescós, Raúl, Martorell, Miquel, Pons, Antoni, Garnham, Andrew P, Stathis, Christos C, McConell, Glenn K

“…Beetroot juice, which is rich in nitrate (NO3 (-)), has been shown in some studies to decrease oxygen consumption (V̇o2) for a given exercise workload, i.e.,…”
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Undercarboxylated Osteocalcin Improves Insulin‐Stimulated Glucose Uptake in Muscles of Corticosterone‐Treated Mice by Lin, Xuzhu, Parker, Lewan, McLennan, Emma, Hayes, Alan, McConell, Glenn, Brennan‐Speranza, Tara C, Levinger, Itamar

“…ABSTRACT Short‐term administration of glucocorticoids (GCs) impairs muscle insulin sensitivity at least in part via the reduction of undercarboxylated…”
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Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK by Merry, Troy L, Steinberg, Gregory R, Lynch, Gordon S, McConell, Glenn K

“…Reactive oxygen species (ROS) and nitric oxide (NO) have been implicated in the regulation of skeletal muscle glucose uptake during contraction, and there is…”
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Exercise-induced increase in muscle insulin sensitivity in men is amplified when assessed using a meal test by Voldstedlund, Christian T., Sjøberg, Kim A., Schlabs, Farina L., Sigvardsen, Casper M., Andersen, Nicoline R., Holst, Jens J., Hartmann, Bolette, Wojtaszewski, Jørgen F. P., Kiens, Bente, McConell, Glenn K., Richter, Erik A.

“…Aims/hypothesis Exercise has a profound effect on insulin sensitivity in skeletal muscle. The euglycaemic–hyperinsulinaemic clamp (EHC) is the gold standard…”
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Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by a paternal high‐fat diet by Falcão‐Tebas, Filippe, Kuang, Jujiao, Arceri, Chelsea, Kerris, Jarrod P., Andrikopoulos, Sofianos, Marin, Evelyn C., McConell, Glenn K.

“…Key points A paternal high‐fat diet/obesity before mating can negatively influence the metabolism of offspring. Exercise only early in life has a remarkable…”
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The Effect of Acute Exercise on Undercarboxylated Osteocalcin and Insulin Sensitivity in Obese Men by Levinger, Itamar, Jerums, George, Stepto, Nigel K, Parker, Lewan, Serpiello, Fabio R, McConell, Glenn K, Anderson, Mitchell, Hare, David L, Byrnes, Elizabeth, Ebeling, Peter R, Seeman, Ego

“…ABSTRACT Acute exercise improves insulin sensitivity for hours after the exercise is ceased. The skeleton contributes to glucose metabolism and insulin…”
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Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism by McConell, Glenn K, Rattigan, Stephen, Lee-Young, Robert S, Wadley, Glenn D, Merry, Troy L

“…Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO…”
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Leptin Enhances Insulin Sensitivity by Direct and Sympathetic Nervous System Regulation of Muscle IGFBP-2 Expression: Evidence From Nonrodent Models by Yau, Steven W, Henry, Belinda A, Russo, Vincenzo C, McConell, Glenn K, Clarke, Iain J, Werther, George A, Sabin, Matthew A

“…Leptin is produced from white adipose tissue and acts primarily to regulate energy balance. Obesity is associated with leptin resistance and increased…”
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Six high-intensity interval training sessions over 5 days increases maximal oxygen uptake, endurance capacity, and sub-maximal exercise fat oxidation as much as 6 high-intensity interval training sessions over 2 weeks by Atakan, Muhammed M., Güzel, Yasemin, Bulut, Süleyman, Koşar, Şükran N., McConell, Glenn K., Turnagöl, Hüseyin H.

“…•This is the first study showing that 6 high-intensity interval training (HIIT) sessions over just 5 days is just as effective in increasing maximal oxygen…”
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Short-term intensified cycle training alters acute and chronic responses of PGC1α and Cytochrome C oxidase IV to exercise in human skeletal muscle by Stepto, Nigel K, Benziane, Boubacar, Wadley, Glenn D, Chibalin, Alexander V, Canny, Benedict J, Eynon, Nir, McConell, Glenn K

“…Reduced activation of exercise responsive signalling pathways have been reported in response to acute exercise after training; however little is known about…”
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