Search Results - "McCombe, P.A"

Gender differences in autoimmune disease by Ngo, S.T, Steyn, F.J, McCombe, P.A

“…Highlights • Gender differences that exist in autoimmunity follow a female bias. • Differences in immune response may underlie gender bias in autoimmune…”
Get full text

Body mass index and dietary intervention: Implications for prognosis of amyotrophic lateral sclerosis by Ngo, S.T, Steyn, F.J, McCombe, P.A

“…Abstract Amyotrophic lateral sclerosis (ALS) is an adult onset, neurodegenerative disease that is characterized by the loss of upper (corticospinal) and lower…”
Get full text

Cloning of a new form of EAAT2/GLT-1 from human and rodent brains by Lee, A., Klinkradt, S., McCombe, P.A., Pow, D.V.

“…•We have cloned a new variant of GLT-1, which we call GLT-1d that varies at its C-terminus as a consequence of alternate RNA splicing.•The 5′ end of GLT-1d…”
Get full text

Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood by Mantovani, S, Gordon, R, Macmaw, J.K, Pfluger, C.M.M, Henderson, R.D, Noakes, P.G, McCombe, P.A, Woodruff, T.M

“…Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by the progressive loss of motor neurons within the central…”
Get full text

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis by Ngo, S.T, Steyn, F.J, Huang, L, Mantovani, S, Pfluger, C.M.M, Woodruff, T.M, O'Sullivan, J.D, Henderson, R.D, McCombe, P.A

“…Abstract Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the loss of upper cortical and lower motor neurons…”
Get full text

Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis by McCombe, P.A, Pfluger, C, Singh, P, Lim, C.Y.H, Airey, C, Henderson, R.D

“…Abstract There is a need for a blood biomarker of disease activity in ALS. This marker needs to measure the loss of motor neurones. Phosphorylated…”
Get full text

Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke by Singh, P, Yan, J, Hull, R, Read, S, O'Sullivan, J, Henderson, R.D, Rose, S, Greer, J.M, McCombe, P.A

“…Abstract For the study of stroke outcomes, there is the need for measurements of severity of stroke damage. Phosphorylated neurofilament heavy protein (pNfH)…”
Get full text

The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1G93A mice by Ngo, S.T, Baumann, F, Ridall, P.G, Pettitt, A.N, Henderson, R.D, Bellingham, M.C, McCombe, P.A

“…Abstract Objective To assess the relationship between Bayesian MUNE and histological motor neuron counts in wild-type mice and in an animal model of ALS…”
Get full text

Reduced levels of interleukin 33 and increased levels of soluble ST2 in subjects with amyotrophic lateral sclerosis by Lin, C.Y, Pfluger, C.M, Henderson, R.D, McCombe, P.A

“…Abstract Interleukin 33 (IL-33) is a cytokine that functions as an alarmin and is released from damaged tissue. The receptor for IL-33 is ST2, which exists as…”
Get full text

Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barré syndrome patients compared to controls by Harness, J, McCombe, P.A

“…Abstract Guillain-Barré syndrome (GBS) is a severe, self-limiting, autoimmune motor neuropathy. This study was performed to investigate the numbers of…”
Get full text

T cells from patients with Guillain-Barré syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1 by McCombe, P.A, Csurhes, P.A

“…Abstract Guillain-Barré syndrome (GBS) is an acquired demyelinating neuropathy, characterized by infiltration of peripheral nerves with macrophages and T…”
Get full text

P02-53 Growth Hormone: a potential biomarker for disease progression in Amyotrophic Lateral Sclerosis (ALS) by Ngo, S.T, Steyn, F.J, Lee, K, Veldhuis, J.D, Bellingham, M.C, McCombe, P.A, Chen, C

Get full text

P7-22 Novel upper and lower motor neuron markers in amyotrophic lateral sclerosis by Baumann, F, Henderson, R.D, Rose, S.E, Pettitt, A, Pannek, K, McCombe, P.A

Get full text

Predictions of resting energy expenditure in amyotrophic lateral sclerosis are greatly impacted by reductions in fat free mass by Ioannides, Z.A., Steyn, F.J., Mi, J.D., Henderson, R.D., McCombe, P.A., Ngo, S.T.

“…Background: Hypermetabolism, defined as an increase in measured resting energy expenditure (mREE) relative to predicted REE (pREE), is recognised as an…”
Get full text

The Role of immune and inflammatory mechanisms in ALS by McCombe, P A, Henderson, R D

“…Amyotrophic lateral sclerosis (ALS) is a severe progressive neurodegenerative disease. The cause is unknown, but genetic abnormalities have been identified in…”
Get more information

Monocyte CD14 and HLA-DR expression increases with disease duration and severity in amyotrophic lateral sclerosis by Mcgill, R.B., Steyn, F.J., Ngo, S.T., Thorpe, K.A., Heggie, S., Henderson, R.D., Mccombe, P.A., Woodruff, T.M.

“…Objective: To investigate changes in immune markers and frequencies throughout disease progression in patients with amyotrophic lateral sclerosis (ALS)…”
Get full text

Recombinant EPF /Chaperonin 10 Promotes the Survival of O4-Positive Pro-Oligodendrocytes Prepared from Neonatal Rat Brain by McCombe, P. A.

“…Chaperonin 10 (cpn 10) is a small heat-shock protein that is usually intracellular. Early pregnancy factor (EPF), a biologically active protein that was first…”
Get full text

Apoptosis in the nervous system in experimental allergic encephalomyelitis by Pender, M P, Nguyen, K B, McCombe, P A, Kerr, J F

“…We report here for the first time the occurrence of apoptosis of cells in the spinal cord in experimental allergic encephalomyelitis (EAE), an autoimmune,…”
Get more information

T cell apoptosis, but not microglial adoptosis, is mediated by the FAS pathway in the central nervous system in experimental autoimmune encephalomyelitis by White, C.A., McCombe, P.A., Pender, M.

Get full text

Apoptosis of Vβ8.2 + T lymphocytes in the spinal cord during recovery from experimental autoimmune encephalomyelitis induced in Lewis rats by inoculation with myelin basic protein by McCombe, P.A., Nickson, I., Tabi, Z., Pender, M.P.

“…To study T cell apoptosis during spontaneous recovery from experimental autoimmune encephalomyelitis (EAE), we extracted lymphocytes from the spinal cords of…”
Get full text