Search Results - "McCole, Declan F"

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli by Shawki, Ali, McCole, Declan F

“…Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The…”
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Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2 by McCole, Declan F.

“…Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) has been identified as an inflammatory bowel disease (IBD) candidate gene. However, the mechanism…”
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Deficiency of intestinal mucin‐2 ameliorates experimental alcoholic liver disease in mice by Hartmann, Phillipp, Chen, Peng, Wang, Hui J., Wang, Lirui, McCole, Declan F., Brandl, Katharina, Stärkel, Peter, Belzer, Clara, Hellerbrand, Claus, Tsukamoto, Hidekazu, Ho, Samuel B., Schnabl, Bernd

“…The intestinal mucus layer protects the epithelium from noxious agents, viruses, and pathogenic bacteria present in the gastrointestinal tract. It is composed…”
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JAK-STAT Pathway Regulation of Intestinal Permeability: Pathogenic Roles and Therapeutic Opportunities in Inflammatory Bowel Disease by Lei, Hillmin, Crawford, Meli'sa S, McCole, Declan F

“…The epithelial barrier forms the interface between luminal microbes and the host immune system and is the first site of exposure to many of the environmental…”
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PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer by Spalinger, Marianne R., Manzini, Roberto, Hering, Larissa, Riggs, Julianne B., Gottier, Claudia, Lang, Silvia, Atrott, Kirstin, Fettelschoss, Antonia, Olomski, Florian, Kündig, Thomas M., Fried, Michael, McCole, Declan F., Rogler, Gerhard, Scharl, Michael

“…Variants in the gene locus encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) are associated with inflammatory disorders, including inflammatory…”
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ZOning in on Novel Roles for Zonula Occludens Proteins in Epithelial Repair by Mccole, Declan F.

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Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis by Barrett, Kim E, McCole, Declan F

“…Summary Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) contribute to epithelial damage and ion transport dysfunction (key events in…”
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Cholera Toxin Disrupts Barrier Function by Inhibiting Exocyst-Mediated Trafficking of Host Proteins to Intestinal Cell Junctions by Guichard, Annabel, Cruz-Moreno, Beatriz Cruz, Aguilar, Berenice, van Sorge, Nina M., Kuang, Jennifer, Kurkciyan, Adrianne A., Wang, Zhipeng, Hang, Saiyu, Pineton de Chambrun, Guillaume P., McCole, Declan F., Watnick, Paula, Nizet, Victor, Bier, Ethan

“…Cholera toxin (CT), a virulence factor elaborated by Vibrio cholerae, is sufficient to induce the severe diarrhea characteristic of cholera. The enzymatic…”
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AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species by King, Stephanie J, Bunz, Michael, Chappell, Alfred, Scharl, Michael, Docherty, Michael, Jung, Barbara, Lytle, Christian, McCole, Declan F

“…Reactive oxygen species such as H O are believed to play a prominent role in the injury and loss of transport function that affect the intestinal epithelium in…”
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Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice by Deol, Poonamjot, Ruegger, Paul, Logan, Geoffrey D., Shawki, Ali, Li, Jiang, Mitchell, Jonathan D., Yu, Jacqueline, Piamthai, Varadh, Radi, Sarah H., Hasnain, Sana, Borkowski, Kamil, Newman, John W., McCole, Declan F., Nair, Meera G., Hsiao, Ansel, Borneman, James, Sladek, Frances M.

“…Inflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are…”
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CXCR2-Dependent Mucosal Neutrophil Influx Protects against Colitis-Associated Diarrhea Caused by an Attaching/Effacing Lesion-Forming Bacterial Pathogen by Spehlmann, Martina E, Dann, Sara M, Hruz, Petr, Hanson, Elaine, McCole, Declan F, Eckmann, Lars

“…Enteropathogenic Escherichia coli (EPEC) is a major cause of diarrheal disease in young children, yet symptoms and duration are highly variable for unknown…”
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IBD candidate genes and intestinal barrier regulation by McCole, Declan F

“…Technological advances in the large scale analysis of human genetics have generated profound insights into possible genetic contributions to chronic diseases…”
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Epithelial-microbial diplomacy: escalating border tensions drive inflammation in inflammatory bowel disease by King, Stephanie J, McCole, Declan F

“…Inflammatory bowel diseases (IBD) are chronic conditions of the gastrointestinal tract-the main site of host-microbial interaction in the body. Development of…”
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Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis by Morón, Belén, Spalinger, Marianne, Kasper, Stephanie, Atrott, Kirstin, Frey-Wagner, Isabelle, Fried, Michael, McCole, Declan F, Rogler, Gerhard, Scharl, Michael

“…Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2). As PTPN2 is known to be a negative…”
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A crucial role for HVEM and BTLA in preventing intestinal inflammation by Steinberg, Marcos W, Turovskaya, Olga, Shaikh, Raziya B, Kim, Gisen, McCole, Declan F, Pfeffer, Klaus, Murphy, Kenneth M, Ware, Carl F, Kronenberg, Mitchell

“…The interaction between the tumor necrosis factor (TNF) family member LIGHT and the TNF family receptor herpes virus entry mediator (HVEM) co-stimulates T…”
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Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK by Guo, June, Pereira, Troy J, Mori, Yusaku, Gonzalez Medina, Marel, Breen, Danna M, Dalvi, Prasad S, Zhang, Hangjun, McCole, Declan F, McBurney, Michael W, Heximer, Scott P, Tsiani, Evangelia L, Dolinsky, Vernon W, Giacca, Adria

“…We have shown that both insulin and resveratrol (RSV) decrease neointimal hyperplasia in chow-fed rodents via mechanisms that are in part overlapping and…”
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The ClC-2 Chloride Channel Activator, Lubiprostone, Improves Intestinal Barrier Function in Biopsies from Crohn's Disease but Not Ulcerative Colitis Patients by Park, Young Su, Kang, Sang Bum, Marchelletta, Ronald R, Penrose, Harrison M, Ruiter-Visser, Roos, Jung, Barbara, Docherty, Michael J, Boland, Brigid S, Sandborn, William J, McCole, Declan F

“…The prostone analog, lubiprostone, is approved to manage constipation-predominant irritable bowel syndrome. Lubiprostone also protects intestinal mucosal…”
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All Hands on Deck: Commensals, Th17 Cells, and Neutrophils Provide Short-term Compensation of Constitutive Permeability Defects Against Acute Infection by McCole, Declan F., PhD

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Crohn's disease‐associated polymorphism within the PTPN2 gene affects muramyl‐dipeptide‐induced cytokine secretion and autophagy by Scharl, Michael, Mwinyi, Jessica, Fischbeck, Anne, Leucht, Katharina, Eloranta, Jyrki J., Arikkat, Joba, Pesch, Theresa, Kellermeier, Silvia, Mair, Alma, Kullak‐Ublick, Gerd A., Truninger, Kaspar, Noreen, Faiza, Regula, Jaroslaw, Gaj, Pawel, Pittet, Valerie, Mueller, Christoph, Hofmann, Claudia, Fried, Michael, McCole, Declan F., Rogler, Gerhard

“…Background: The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non‐receptor type 2 (PTPN2)…”
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Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells by Scharl, Michael, Wojtal, Kacper A., Becker, Helen M., Fischbeck, Anne, Frei, Pascal, Arikkat, Joba, Pesch, Theresa, Kellermeier, Silvia, Boone, David L., Weber, Achim, Loessner, Martin J., Vavricka, Stephan R., Fried, Michael, McCole, Declan F., Rogler, Gerhard

“…Background: Autophagy is a process of central importance for maintaining cell homeostasis, survival, and the regulation of inflammation. Recent studies…”
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