Search Results - "McClymont, Sarah A"

Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA by Turner, Tychele N., Hormozdiari, Fereydoun, Duyzend, Michael H., McClymont, Sarah A., Hook, Paul W., Iossifov, Ivan, Raja, Archana, Baker, Carl, Hoekzema, Kendra, Stessman, Holly A., Zody, Michael C., Nelson, Bradley J., Huddleston, John, Sandstrom, Richard, Smith, Joshua D., Hanna, David, Swanson, James M., Faustman, Elaine M., Bamshad, Michael J., Stamatoyannopoulos, John, Nickerson, Deborah A., McCallion, Andrew S., Darnell, Robert, Eichler, Evan E.

“…We performed whole-genome sequencing (WGS) of 208 genomes from 53 families affected by simplex autism. For the majority of these families, no copy-number…”
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Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons by Boyd, Rachel J, McClymont, Sarah A, Barrientos, Nelson B, Hook, Paul W, Law, William D, Rose, Rebecca J, Waite, Eric L, Rathinavelu, Jay, Avramopoulos, Dimitrios, McCallion, Andrew S

“…To overcome the ethical and technical limitations of in vivo human disease models, the broader scientific community frequently employs model organism-derived…”
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m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency by Collignon, Evelyne, Cho, Brandon, Furlan, Giacomo, Fothergill-Robinson, Julie, Martin, Sylvia-Bryn, McClymont, Sarah A., Ross, Robert L., Limbach, Patrick A., Ramalho-Santos, Miguel

“…Embryos across metazoan lineages can enter reversible states of developmental pausing, or diapause, in response to adverse environmental conditions. The…”
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Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease by Hook, Paul W., McClymont, Sarah A., Cannon, Gabrielle H., Law, William D., Morton, A. Jennifer, Goff, Loyal A., McCallion, Andrew S.

“…Genetic variation modulating risk of sporadic Parkinson disease (PD) has been primarily explored through genome-wide association studies (GWASs). However, like…”
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SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer by Edelman, Hannah E, McClymont, Sarah A, Tucker, Tori R, Pineda, Santiago, Beer, Rebecca L, McCallion, Andrew S, Parsons, Michael J

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of cancer with high mortality. The cellular origins of PDAC are largely unknown;…”
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Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons by McClymont, Sarah A., Hook, Paul W., Soto, Alexandra I., Reed, Xylena, Law, William D., Kerans, Samuel J., Waite, Eric L., Briceno, Nicole J., Thole, Joey F., Heckman, Michael G., Diehl, Nancy N., Wszolek, Zbigniew K., Moore, Cedric D., Zhu, Heng, Akiyama, Jennifer A., Dickel, Diane E., Visel, Axel, Pennacchio, Len A., Ross, Owen A., Beer, Michael A., McCallion, Andrew S.

“…The progressive loss of midbrain (MB) dopaminergic (DA) neurons defines the motor features of Parkinson disease (PD), and modulation of risk by common variants…”
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Novel temporal, fine‐scale and growth variation phenotypes in roots of adult‐stage maize (Zea mays L.) in response to low nitrogen stress by GAUDIN, AMELIE C. M., MCCLYMONT, SARAH A., HOLMES, BRIDGET M., LYONS, ERIC, RAIZADA, MANISH N.

“…ABSTRACT There is interest in discovering root traits associated with acclimation to nutrient stress. Large root systems, such as in adult maize, have proven…”
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Nitrogen Adaptation Strategy of the Wild Teosinte Ancestor of Modern Maize, Zea mays subsp. parviglumis by Gaudin, Amelie C.M, McClymont, Sarah A, Raizada, Manish N

“…Examination of wild ancestors can identify which traits have been altered by selection as possible targets for genetic improvement. We investigated the whole…”
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The effect of altered dosage of a mutant allele of Teosinte branched 1 (tb1-ref) on the root system of modern maize by Gaudin, Amelie C M, McClymont, Sarah A, Soliman, Sameh S M, Raizada, Manish N

“…There was ancient human selection on the wild progenitor of modern maize, Balsas teosinte, for decreased shoot branching (tillering), in order to allow more…”
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ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm by Gould, Russell A., Aziz, Hamza, Woods, Courtney E., Seman-Senderos, Manuel Alejandro, Sparks, Elizabeth, Preuss, Christoph, Wünnemann, Florian, Bedja, Djahida, Moats, Cassandra R., McClymont, Sarah A., Rose, Rebecca, Sobreira, Nara, Ling, Hua, MacCarrick, Gretchen, Kumar, Ajay Anand, Luyckx, Ilse, Cannaerts, Elyssa, Verstraeten, Aline, Björk, Hanna M., Lehsau, Ann-Cathrin, Jaskula-Ranga, Vinod, Lauridsen, Henrik, Shah, Asad A., Bennett, Christopher L., Ellinor, Patrick T., Lin, Honghuang, Isselbacher, Eric M., Lino Cardenas, Christian Lacks, Butcher, Jonathan T., Hughes, G. Chad, Lindsay, Mark E., Mertens, Luc, Franco-Cereceda, Anders, Verhagen, Judith M. A., Wessels, Marja, Mohamed, Salah A., Eriksson, Per, Mital, Seema, Van Laer, Lut, Loeys, Bart L., Andelfinger, Gregor, McCallion, Andrew S., Dietz, Harry C.

“…Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–2%) 1 – 3 that frequently presents with ascending aortic aneurysm…”
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