Search Results - "McClure, Ryan S"
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Hi-C metagenome sequencing reveals soil phage–host interactions
Published in Nature communications (23-11-2023)“…Bacteriophages are abundant in soils. However, the majority are uncharacterized, and their hosts are unknown. Here, we apply high-throughput chromosome…”
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Gene co-expression network analysis in zebrafish reveals chemical class specific modules
Published in BMC genomics (13-09-2021)“…Abstract Background Zebrafish is a popular animal model used for high-throughput screening of chemical hazards, however, investigations of transcriptomic…”
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Coupling Genome-wide Transcriptomics and Developmental Toxicity Profiles in Zebrafish to Characterize Polycyclic Aromatic Hydrocarbon (PAH) Hazard
Published in International journal of molecular sciences (25-05-2019)“…Polycyclic Aromatic Hydrocarbons (PAHs) are diverse environmental pollutants associated with adverse human health effects. Many studies focus on the…”
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Tripogon loliiformis tolerates rapid desiccation after metabolic and transcriptional priming during initial drying
Published in Scientific reports (23-11-2023)“…Crop plants and undomesticated resilient species employ different strategies to regulate their energy resources and growth. Most crop species are sensitive to…”
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Toward a Better Understanding of Species Interactions through Network Biology
Published in mSystems (28-05-2019)“…Within the last decade, there has been an explosion of multi-omics data generated for several microbial systems. At the same time, new methods of analysis have…”
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Unified feature association networks through integration of transcriptomic and proteomic data
Published in PLoS computational biology (17-09-2019)“…High-throughput multi-omics studies and corresponding network analyses of multi-omic data have rapidly expanded their impact over the last 10 years. As…”
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Selection, Succession, and Stabilization of Soil Microbial Consortia
Published in mSystems (01-07-2019)“…Soil microorganisms play fundamental roles in cycling of soil carbon, nitrogen, and other nutrients, yet we have a poor understanding of how soil microbiomes…”
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Improving network inference algorithms using resampling methods
Published in BMC bioinformatics (12-10-2018)“…Relatively small changes to gene expression data dramatically affect co-expression networks inferred from that data which, in turn, can significantly alter the…”
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3' RNA-seq is superior to standard RNA-seq in cases of sparse data but inferior at identifying toxicity pathways in a model organism
Published in Frontiers in bioinformatics (27-07-2023)“…The application of RNA-sequencing has led to numerous breakthroughs related to investigating gene expression levels in complex biological systems. Among these…”
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Phenotypic responses to interspecies competition and commensalism in a naturally-derived microbial co-culture
Published in Scientific reports (10-01-2018)“…The fundamental question of whether different microbial species will co-exist or compete in a given environment depends on context, composition and…”
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Unlocking the Constraints of Cyanobacterial Productivity: Acclimations Enabling Ultrafast Growth
Published in mBio (26-07-2016)“…Harnessing the metabolic potential of photosynthetic microbes for next-generation biotechnology objectives requires detailed scientific understanding of the…”
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Concentration-response gene expression analysis in zebrafish reveals phenotypically-anchored transcriptional responses to retene
Published in Frontiers in toxicology (25-08-2022)“…Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants and are associated with human disease. Canonically, many PAHs induce toxicity…”
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Indirect Interspecies Regulation: Transcriptional and Physiological Responses of a Cyanobacterium to Heterotrophic Partnership
Published in mSystems (01-03-2017)“…The mechanisms by which microbes interact in communities remain poorly understood. Here, we interrogated specific interactions between photoautotrophic and…”
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Integrated in silico Analyses of Regulatory and Metabolic Networks of Synechococcus sp. PCC 7002 Reveal Relationships between Gene Centrality and Essentiality
Published in Life (Basel, Switzerland) (27-03-2015)“…Cyanobacteria dynamically relay environmental inputs to intracellular adaptations through a coordinated adjustment of photosynthetic efficiency and carbon…”
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Computational Analysis of Interactions of the Oral Microbiota
Published in Current oral health reports (01-06-2019)“…Purpose of Review The human oral microbiome is a complex site containing many hundreds of species with the community response of these species having a large…”
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Species-specific transcriptomic network inference of interspecies interactions
Published in The ISME Journal (01-08-2018)“…The advent of high-throughput ‘omics approaches coupled with computational analyses to reconstruct individual genomes from metagenomes provides a basis for…”
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Integrated network modeling approach defines key metabolic responses of soil microbiomes to perturbations
Published in Scientific reports (02-07-2020)“…The soil environment is constantly changing due to shifts in soil moisture, nutrient availability and other conditions. To contend with these changes, soil…”
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Network analysis of transcriptomics expands regulatory landscapes in Synechococcus sp. PCC 7002
Published in Nucleic acids research (14-10-2016)“…Cyanobacterial regulation of gene expression must contend with a genome organization that lacks apparent functional context, as the majority of cellular…”
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Graphene oxide exposure alters gut microbial community composition and metabolism in an in vitro human model
Published in NanoImpact (01-04-2023)“…Graphene oxide (GO) nanomaterials have unique physicochemical properties that make them highly promising for biomedical, environmental, and agricultural…”
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Multi-Omic Dynamics Associate Oxygenic Photosynthesis with Nitrogenase-Mediated H2 Production in Cyanothece sp. ATCC 51142
Published in Scientific reports (03-11-2015)“…To date, the proposed mechanisms of nitrogenase-driven photosynthetic H 2 production by the diazotrophic unicellular cyanobacterium Cyanothece sp . ATCC 51142…”
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