Search Results - "McClure, Don B."

An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors by Falcon, Beverly L, Swearingen, Michelle, Gough, Wendy H, Lee, Linda, Foreman, Robert, Uhlik, Mark, Hanson, Jeff C, Lee, Jonathan A, McClure, Don B, Chintharlapalli, Sudhakar

“…Vascular endothelial growth factor (VEGF) plays a dominant role in angiogenesis. While inhibitors of the VEGF pathway are approved for the treatment of a…”
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Identification of heme as the ligand for the orphan nuclear receptors REV-ERBα and REV-ERBβ by Burris, Thomas P, Huang, Pengxiang, Rastinejad, Fraydoon, Rogers, Pamela M, Khorasanizadeh, Sepideh, Raghuram, Srilatha, Stayrook, Keith R, McClure, Don B, Nosie, Amanda K, Burris, Lorri L

“…The nuclear receptors REV-ERBα (encoded by NR1D1 ) and REV-ERBβ ( NR1D2 ) have remained orphans owing to the lack of identified physiological ligands. Here we…”
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Biochemical and kinetic characterization of BACE1: investigation into the putative species‐specificity for β‐ and β′‐cleavage sites by human and murine BACE1 by Yang, Hsiu‐Chiung, Chai, Xiyun, Mosior, Marian, Kohn, Wayne, Boggs, Leonard N., Erickson, Jon A., McClure, Don B., Yeh, Wu‐Kuang, Zhang, Lianshen, Gonzalez‐DeWhitt, Patricia, Mayer, John P., Martin, Jose Alfredo, Hu, Jingdan, Chen, Shu‐hui, Bueno, Ana Belen, Little, Sheila P., McCarthy, James R., May, Patrick C.

“…β‐amyloid peptides (Aβ) are produced by a sequential cleavage of amyloid precursor protein (APP) by β‐ and γ‐secretases. The lack of Aβ production in beta‐APP…”
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P4-339 Stereoselective inhibition of amyloid beta peptide secretion by LY450139, a novel functional gamma secretase inhibitor by Gitter, Bruce D., Czilli, Dan L., Li, Weiying, Dieckman, Donna K., Bender, Mark H., Nissen, Jeffrey S., Mabry, Thomas E., Yin, Tinggui, Boggs, Leonard N., McClure, Don B., Little, Sheila P., Johnstone, Edward M., Audia, James E., May, Patrick C., Hyslop, Paul A.

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Derivation and characterization of monoclonal antibodies against human folypolyglutamate synthetase by Dotzlaf, Joe, Carpenter, John, Luo, Shuang, Miles, Rebecca R, Fisher, Deborah, Qian, Yue-Wei, Ehsani, Mariam, Wang, Xiliang, Lin, Aimin, McClure, Don B, Chen, Victor J, Zuckerman, Steven H

“…Folypolyglutamate synthetase (FPGS) plays a critical role in the cellular retention of both folates and antifolates. Resistance to antifolates is in part…”
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Characterization and Novel Purification of Recombinant Human Protein C from Three Mammalian Cell Lines by Yan, S.C. Betty, Razzano, Pam, Chao, Y. Bernice, Walls, Jenna D, Berg, David T, McClure, Don B, Grinnell, Brain W

“…Human Protein C (HPC), an antithrombotic factor with potential clinical utility, is a vitamin K-dependent protein that has several complex post-translational…”
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Derivation and characterization of a monoclonal antibody against human glycinamide ribonucleotide formyltransferase by Dotzlaf, Joe, Carpenter, John, Luo, Shuang, Roberts, Edda F, Solenberg, Patricia J, Qian, Yue-Wei, Lin, Aimin, He, Xiaohua, Sandusky, George E, McClure, Don B, Chen, Victor J, Zuckerman, Steven H

“…Glycinamide ribonucleotide formyltransferase (GARFT) is a trifunctional enzyme involved in purine biosynthesis. Its central role in folate metabolism has made…”
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Synthesis and in vitro biological activity of 4α-(2-propenyl)-5α-cholest-24-en-3α-ol: A 24,25-dehydro analog of the hypocholesterolemic agent 4α-(2-propenyl)-5α-cholestan-3α-ol by Lin, Ho-Shen, Rampersaud, Ashraff A, Richett, Michael E, Harper, Richard W, Beavers, Lisa S, McClure, Don B, Gardner, Anthony J, Eacho, Patrick I, Foxworthy, Patricia S, Gadski, Robert A

“…4α-(2-Propenyl)-5α-cholestan-3α-ol (LY295427) was previously identified from a Chinese hamster ovary (CHO) cell-based low density lipoprotein…”
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Synthesis and in vitro biological activity of 4α-(2-propenyl)-5α-cholest-24-en-3α,12α-diol, a 12α-hydroxyl analog of 4α-(2-propenyl)-5α-cholest-24-en-3α-ol: The latter is a potent activator of the low-density lipoprotein receptor promoter by Lin, Ho-Shen, Rampersaud, Ashraff A, Beavers, Lisa S, McClure, Don B, Gardner, Anthony J, Eacho, Patrick I, Foxworthy, Patricia S, Gadski, Robert A

“…4α-(2-Propenyl)-5α-cholest-24-en-3α-ol ( 3) was shown recently in a Chinese hamster ovary (CHO) cell-based low-density lipoprotein receptor/luciferase…”
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Anchorage-independent colony formation of SV40 transformed BALB/c-3T3 cells in serum-free medium: role of cell- and serum-derived factors by McClure, D B

“…The colony-forming response of SV40 transformed BALB/c-3T3 cells in agarose suspension culture was studied in a serum-free medium (with insulin, transferrin…”
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Development of a serum-free medium for growth of NS-1 mouse myeloma cells and its application to the isolation of NS-1 hybridomas by Kawamoto, T, Sato, J D, Le, A, McClure, D B, Sato, G H

“…In this study, we have devised a hormone-supplemented, lipid-enriched serum-free medium, designated KSLM, that supports the growth of NS-1 mouse myeloma cells…”
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Identification of heme as the ligand for the orphan nuclear receptors REV-ERB[alpha] and REV-ERB[beta] by Raghuram, Srilatha, Stayrook, Keith R, Huang, Pengxiang, Rogers, Pamela M, Nosie, Amanda K, McClure, Don B, Burris, Lorri L, Khorasanizadeh, Sepideh, Burris, Thomas P, Rastinejad, Fraydoon

“…The nuclear receptors REV-ERBalpha (encoded by NR1D1) and REV-ERBbeta (NR1D2) have remained orphans owing to the lack of identified physiological ligands. Here…”
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Purified HDL-apolipoproteins, A-I and C-III, substitute for HDL in promoting the growth of SV40-transformed REF52 cells in serum-free medium by Chen, J K, LaBrake-Farmer, S, McClure, D B

“…The lipid-free apolipoproteins of human high density lipoprotein (HDL) have been assayed for their ability to substitute for native HDL in promoting the growth…”
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Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line by Chen, J K, Okamoto, T, Sato, J D, Sato, G H, McClure, D B

“…The biochemical basis for the cholesterol-dependent growth phenotype of the NS-1 myeloma cell line has been investigated. In one series of experiments, the…”
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Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta by Raghuram, Srilatha, Stayrook, Keith R, Huang, Pengxiang, Rogers, Pamela M, Nosie, Amanda K, McClure, Don B, Burris, Lorri L, Khorasanizadeh, Sepideh, Burris, Thomas P, Rastinejad, Fraydoon

“…The nuclear receptors REV-ERBalpha (encoded by NR1D1) and REV-ERBbeta (NR1D2) have remained orphans owing to the lack of identified physiological ligands. Here…”
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Post-translational processing events in the secretion pathway of human protein C, a complex vitamin K-dependent antithrombotic factor by MCCLURE, D. B, WALLS, J. D, GRINNELL, B. W

“…Human protein C (HPC) undergoes several post-translational modifications, including gamma-carboxylation, N-linked glycosylation, and internal proteolytic…”
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Synthesis of 4α-(2-propenyl)-5,6-secocholestan-3α-ol, a Novel B-ring Seco Analog of the Hypocholesterolemic Agent 4α-(2-propenyl)-5α-cholestan-3α-ol by Lin, Ho-Shen, Rampersaud, Ashraff A., Richett, Michael E., Beavers, Lisa S., McClure, Don B., Gadski, Robert A.

“…4α-(2-Propenyl)-5α-cholestan-3α-ol (LY295427) was previously identified from a CHO cell-based assay to be a potent LDL receptor up-regulator and had…”
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LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins by Bowling, N, Matter, W F, Gadski, R A, McClure, D B, Schreyer, T, Dawson, P A, Vlahos, C J

“…LY295427, (3 alpha,4 alpha,5 alpha)-4-(2-propenylcholestan-3-ol), acts through an unknown mechanism to derepress the transcription of the low density…”
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Synthesis and Biological Evaluation of a New Series of Sterols as Potential Hypocholesterolemic Agents by Lin, Ho-Shen, Rampersaud, Ashraff A, Archer, Robert A, Pawlak, Joseph M, Beavers, Lisa S, Schmidt, Robert J, Kauffman, Raymond F, Bensch, William R, Bumol, Thomas F

“…A new series of sterols was synthesized and tested in a CHO cell-based LDL receptor/luciferase (LDLR/Luc) assay to investigate the capability of derepressing…”
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Role of lipoproteins in growth of human adult arterial endothelial and smooth muscle cells in low lipoprotein-deficient serum by Chen, J K, Hoshi, H, McClure, D B, McKeehan, W L

“…Recently improved culture conditions for human adult arterial endothelial and smooth muscle cells from a wide variety of donors have been used to study the…”
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