Search Results - "McClung, John A."

Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats by L'Abbate, Antonio, Neglia, Danilo, Vecoli, Cecilia, Novelli, Michela, Ottaviano, Virginia, Baldi, Simona, Barsacchi, Renata, Paolicchi, Aldo, Masiello, Pellegrino, Drummond, George S, McClung, John A, Abraham, Nader G

“…Transient reduction in coronary perfusion pressure in the isolated mouse heart increases microvascular resistance (paradoxical vasoconstriction) by an…”
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Predictors of In-hospital Mortality and Acute Myocardial Infarction in Thrombotic Thrombocytopenic Purpura by Balasubramaniyam, Nivas, MD, Kolte, Dhaval, MD, PhD, Palaniswamy, Chandrasekar, MD, Yalamanchili, Kiran, MD, Aronow, Wilbert S., MD, McClung, John A., MD, Khera, Sahil, MD, Sule, Sachin, MD, Peterson, Stephen J., MD, Frishman, William H., MD

“…Abstract Background Despite the widespread availability of plasmapheresis as a therapy, thrombotic thrombocytopenic purpura is associated with significant…”
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Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects by Kruger, Adam L, Peterson, Stephen J, Schwartzman, Michal L, Fusco, Heidi, McClung, John A, Weiss, Melvin, Shenouda, Sylvia, Goodman, Alvin I, Goligorsky, Michael S, Kappas, Attallah, Abraham, Nader G

“…Heme oxygenase (HO) plays a critical role in the regulation of cellular oxidative stress. The effects of the reactive oxygen species scavenger ebselen and the…”
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Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats by Peterson, Stephen J, Husney, Daniel, Kruger, Adam L, Olszanecki, Rafal, Ricci, Francesca, Rodella, Luigi F, Stacchiotti, Alessandra, Rezzani, Rita, McClung, John A, Aronow, Wilbert S, Ikehara, Susumu, Abraham, Nader G

“…Apolipoprotein A1 mimetic peptide (D-4F), synthesized from D-amino acid, enhances the ability of high-density lipoprotein to protect low-density lipoprotein…”
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Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy by Romashko, Mikhail, Schragenheim, Joseph, Abraham, Nader G, McClung, John A

“…Cardiovascular disease remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising strategy…”
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Criteria for Referral of Patients With Advanced Heart Failure for Specialized Palliative Care by Chang, Yuchieh Kathryn, Allen, Larry A, McClung, John A, Denvir, Martin A, Philip, Jennifer, Mori, Masanori, Perez-Cruz, Pedro, Cheng, Shao-Yi, Collins, Anna, Hui, David

“…Patients with advanced heart failure have substantial supportive care needs. Specialist palliative care can be beneficial, but it is unclear who is most…”
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Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications by McClung, John A., Levy, Lior, Garcia, Victor, Stec, David E., Peterson, Stephen J., Abraham, Nader G.

“…Obesity-mediated metabolic syndrome remains the leading cause of death worldwide. Among many potential targets for pharmacological intervention, a promising…”
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Reply: Early Integration of Specialist Palliative Care in Advanced Heart Failure: A Multipronged Approach by Chang, Yuchieh Kathryn, McClung, John A, Allen, Larry A, Philip, Jennifer, Hui, David

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Usefulness of Clopidogrel to Protect Against Diabetes-Induced Vascular Damage by McClung, John A., MD, Kruger, Adam L., DO, Ferraris, Ambra, MD, Vanella, Luca, PhD, Tsenovoy, Petr, MD, Weiss, Melvin B., MD, Abraham, Nader G., PhD

“…Clopidogrel enhances the levels of endothelial nitric oxide and prostacyclin in tissue culture. We have previously described a marked increase in circulating…”
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The pivotal role of heme Oxygenase-1 in reversing the pathophysiology and systemic complications of NAFLD by Sasson, Ariel, Kristoferson, Eva, Batista, Rogerio, McClung, John A., Abraham, Nader G., Peterson, Stephen J.

“…The pathogenesis and molecular pathways involved in non-alcoholic fatty liver disease (NAFLD) are reviewed, as well as what is known about mitochondrial…”
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Referral Criteria to Palliative Care for Patients With Heart Failure: A Systematic Review by Chang, Yuchieh Kathryn, Kaplan, Holland, Geng, Yimin, Mo, Li, Philip, Jennifer, Collins, Anna, Allen, Larry A., McClung, John A., Denvir, Martin A., Hui, David

“…Patients with heart failure have significant symptom burden, care needs, and often a progressive course to end-stage disease. Palliative care referrals may be…”
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Criteria That Promote Timely Referral to Specialist Palliative Care for Patients With Advanced Heart Failure by CHANG, YUCHIEH KATHRYN, PHILIP, JENNIFER, ALLEN, LARRY A., MCCLUNG, JOHN A., HUI, DAVID

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Cardioprotective Heme Oxygenase‐1‐PGC1α Signaling in Epicardial Fat Attenuates Cardiovascular Risk in Humans as in Obese Mice by Singh, Shailendra P., McClung, John A., Thompson, Ellen, Glick, Yosef, Greenberg, Menachem, Acosta‐Baez, Giancarlo, Edris, Basel, Shapiro, Joseph I., Abraham, Nader G.

“…Objective This study investigated whether levels of signaling pathways and inflammatory adipokines in epicardial fat regulate cardiovascular risks in humans…”
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Differences of Lateral and Septal Mitral Annulus Velocity by Tissue Doppler Imaging in the Evaluation of Left Ventricular Diastolic Function by Park, Hyeun S., Naik, Sanjay D., Aronow, Wilbert S., Visintainer, Paul F., Das, Manisha, McClung, John A., Belkin, Robert N.

“…Left ventricular diastolic dysfunction (LVDD) was investigated in 276 outpatients at a university cardiology practice by tissue Doppler imaging of mitral valve…”
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EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice by Cao, Jian, Singh, Shailendra P, McClung, John A, Joseph, Gregory, Vanella, Luca, Barbagallo, Ignazio, Jiang, Houli, Falck, John R, Arad, Michael, Shapiro, Joseph I, Abraham, Nader G

“…We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on vascular function; in addition to its antiapoptotic action,…”
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Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells by Kim, Dong Hyun, Burgess, Angela P, Li, Ming, Tsenovoy, Peter L, Addabbo, Francesco, McClung, John A, Puri, Nitin, Abraham, Nader G

“…Adiponectin, an abundant adipocyte-derived plasma protein that modulates vascular function in type 2 diabetes, has been shown to provide cytoprotection to both…”
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Comparison of Prevalence of >70% Diameter Narrowing of One or More Major Coronary Arteries in Patients With Versus Without Mitral Annular Calcium and Clinically Suspected Coronary Artery Disease by Kannam, Hari, MD, Aronow, Wilbert S., MD, Chilappa, Kiran, MD, Singh, Tarunjit, MD, McClung, John A., MD, Pucillo, Anthony L., MD, Weiss, Melvin B., MD, Kalapatapu, Kumar, MD, Sullivan, Thomas, BS, Monsen, Craig E., MD

“…The prevalence of >70% narrowing of 1, 2, or 3 major coronary arteries and of 3 major coronary arteries was investigated in 2,465 patients (1,437 men, 1,028…”
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EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter by Schragenheim, Joseph, Bellner, Lars, Cao, Jian, Singh, Shailendra P., Bamshad, David, McClung, John A., Maayan, Omri, Meissner, Aliza, Grant, Ilana, Stier, Charles T., Abraham, Nader G.

“…•EET-agonist reduces sodium retention and decreased both NCC and ENaC proteins.•EET agonist improvement of insulin receptor phosphorylation and decreased…”
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Can echocardiographically estimated pulmonary arterial elastance be a non-invasive predictor of pulmonary vascular resistance? by Sinha, Neeraj, Devabhaktuni, Srikala, Kadambi, Aparna, McClung, John A, Aronow, Wilbert S, Lehrman, Stuart G

“…Measurement of pulmonary vascular resistance (PVR) is essential in evaluating a patient with pulmonary hypertension. Data from right heart catheterization…”
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Aortic valve commissural tear mimicking type A aortic dissection by Kupersmith, Andrew C, Belkin, Robert N, McClung, John A, Moggio, Richard A

“…A 52-year-old man came to the local emergency department with symptoms of heart failure and transient chest pain. Transthoracic echocardiography showed severe…”
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