Search Results - "McClue, S"

601 Comparative tissue distribution of the HDAC inhibitor JNJ-26481585 by Bohets, H, Van Uytsel, K, Meulder, M. De, King, P, Hickson, I, Forslund, A, Palmer, P, McClue, S

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5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition by VARRAULT, A, DUNG LE NGUYEN, MCCLUE, S, HARRIS, B, JOUIN, P, BLOCKAERT, J

“…The 5-hydroxytryptamine1A receptor (5-HT1AR) is a G-protein-coupled receptor negatively coupled to adenylyl cyclase (AC). We have studied the functional…”
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Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins by MacNulty, E E, McClue, S J, Carr, I C, Jess, T, Wakelam, M J, Milligan, G

“…The alpha 2-C10 adrenergic receptor from human platelets was expressed permanently in Rat-1 fibroblasts. A series of clones that varied in expression of the…”
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Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in Rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins: studies with site-directed antisera by McClue, S J, Milligan, G

“…DNA encoding the human alpha 2-C-10-adrenergic receptor was transfected into Rat-1 fibroblasts by CaPO4 precipitation, and clones expressing the receptor were…”
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Subacute and chronic in vivo lithium treatment inhibits agonist- and sodium fluoride-stimulated inositol phosphate production in rat cortex by Godfrey, P P, McClue, S J, White, A M, Wood, A J, Grahame-Smith, D G

“…We have investigated the effects of in vivo lithium treatment on cerebral inositol phospholipid metabolism. Twice-daily treatment of rats with LiCl (3 mEq/kg)…”
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5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in the mouse cortex has pharmacological characteristics compatible with mediation via 5-HT2 receptors but this response does not reflect altered 5-HT2 function after 5,7-dihydroxytryptamine lesioning or repeated antidepressant treatments by Godfrey, P P, McClue, S J, Young, M M, Heal, D J

“…5-Hydroxytryptamine (5-HT; 3 x 10(-8)-1 x 10(-5)M) produced a dose-dependent increase in phosphatidylinositol/polyphosphoinositide (PI) turnover in mouse…”
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Gi3 does not contribute to the inhibition of adenylate cyclase when stimulation of an α2-adrenergic receptor causes activation of both Gi2 and Gi3 by MCCLUE, S. J, SELZER, E, FREISSMUTH, M, MILLIGAN, G

“…Agonist occupancy of the alpha 2-C10 adrenergic receptor in a stable clone (1C) of Rat 1 fibroblasts produced by transfection of cells with genomic DNA…”
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Gi3 does not contribute to the inhibition of adenylate cyclase when stimulation of an alpha 2-adrenergic receptor causes activation of both Gi2 and Gi3 by McClue, S J, Selzer, E, Freissmuth, M, Milligan, G

“…Agonist occupancy of the alpha 2-C10 adrenergic receptor in a stable clone (1C) of Rat 1 fibroblasts produced by transfection of cells with genomic DNA…”
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In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202 by RAYNAUD, Florence I, WHITTAKER, Steven R, VALENTI, Melanie, BRUNTON, Lisa, ECCLES, Suzanne, LANE, David P, WORKMAN, Paul, FISCHER, Peter M, MCCLUE, Steven, WALTON, Michael I, BARRIE, S. Elaine, GARRETT, Michelle D, ROGERS, Paul, CLARKE, Simon J, KELLAND, Lloyd R

“…Purpose: To investigate pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine,…”
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Hallucinogenic drugs are partial agonists of the human platelet shape change response: a physiological model of the 5-HT2 receptor by McClue, S J, Brazell, C, Stahl, S M

“…We have assayed several phenylalkylamine and indolealkylamine hallucinogens, as well as structurally similar nonhallucinogens, for their effect on human…”
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Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats by Gilbert, F, Dourish, C T, Brazell, C, McClue, S, Stahl, S M

“…Various putative agonists of the 5-HT1A receptor subtype induce feeding in rats, probably by activating raphé somatodendritic 5-HT autoreceptors. These drugs…”
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Serotonergic agonists stimulate inositol lipid metabolism in rabbit platelets by Schächter, M, Godfrey, P P, Minchin, M C, McClue, S J, Young, M M

“…The metabolism of inositol phospholipids in response to serotonergic agonists was investigated in rabbit platelets. In platelets prelabelled with…”
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5-Hydroxytryptamine (5-HT)-induced shape change in human platelets determined by computerized data acquisition: correlation with [125I]-iodoLSD binding at 5-HT2 receptors by Brazell, C, McClue, S J, Preston, G C, King, B, Stahl, S M

“…The 5-HT-induced shape change and subsequent aggregation of platelets provides a functional assay for 5-HT2 receptors. In the present study we describe a…”
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Abstract 1361: Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFR) by Saxty, Gordon, Akkari, R, Angibaud, P, Arts, J, Benderitter, P, Berdini, V, Bonnet, P, Cleasby, A, Embrechts, W, Freyne, E, Gilissen, R, King, P, Lacrampe, J, Ligny, Y, Madin, A, Mcclue, S, Mevellec, L, Murray, C W., Newell, H, Page, M, Papanikos, A, Perera, T, Querolle, O, Rees, D C., Rich, S J., Saalau-Bethell, S M., Sement, E, Simmonet, Y, Squires, M, Tronel, V, Ward, G A., Willems, M, B, Wroblowski, Thompson, N T.

“…Abstract Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being…”
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Expression of human M2 muscarinic receptors in Sf9 cells: characterisation and reconstitution with G-proteins by Heitz, F, McClue, S J, Harris, B A, Guenet, C

“…The gene for the human m2 muscarinic receptor was expressed in Sf9 cells using the baculovirus expression system. As assessed by [3H]NMS binding, Sf9 cells…”
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In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R‐roscovitine) by McClue, Steven J., Blake, David, Clarke, Rosemary, Cowan, Angela, Cummings, Lorna, Fischer, Peter M., MacKenzie, Mairi, Melville, Jean, Stewart, Kevin, Wang, Shudong, Zhelev, Nikolai, Zheleva, Daniella, Lane, David P.

“…CDK2 inhibitors have been proposed as effective anti‐cancer therapeutics. We show here that CYC202 (R‐roscovitine) is a potent inhibitor of recombinant…”
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The role and specificity of guanine nucleotide binding proteins in receptor-effector coupling by Milligan, G, Mitchell, F M, Mullaney, I, McClue, S J, McKenzie, F R

“…Nine distinct alpha subunits of guanine nucleotide binding proteins (G-proteins) have now been identified by cDNA cloning. Each of these functions to allow…”
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Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor? by Haynes, Andrea C, Arch, Jonathan R.S, Wilson, Shelagh, Steven Mc Clue, Buckingham, Robin E

“…Food intake was measured in freely fed rats following intracerebroventricular administration of neuropeptide Y (NPY) and several of its analogues and…”
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Discovery of a Novel Family of CDK Inhibitors with the Program LIDAEUS: Structural Basis for Ligand-Induced Disordering of the Activation Loop by Wu, Su Ying, McNae, Iain, Kontopidis, George, McClue, Steven J, McInnes, Campbell, Stewart, Kevin J, Wang, Shudong, Zheleva, Daniella I, Marriage, Howard, Lane, David P, Taylor, Paul, Fischer, Peter M, Walkinshaw, Malcolm D

“…A family of 4-heteroaryl-2-amino-pyrimidine CDK2 inhibitor lead compounds was discovered with the new database-mining program LIDAEUS through in silico…”
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The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2 by McClue, S J, Milligan, G

“…In membranes of undifferentiated neuroblastoma x glioma hybrid cell line NG108-15, the apparent specific binding of [3H]yohimbine measured in the presence of 1…”
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