Search Results - "McClendon, Sebastian"
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Charge neutralization and collapse of the C‐terminal tail of alpha‐synuclein at low pH
Published in Protein science (01-07-2009)“…Alpha‐synuclein (αS) is the primary component of Lewy bodies, the pathological hallmark of Parkinson's Disease. Aggregation of αS is thought to proceed from a…”
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Journal Article -
2
E46K Parkinson’s-Linked Mutation Enhances C-Terminal-to-N-Terminal Contacts in α-Synuclein
Published in Journal of molecular biology (22-05-2009)“…Parkinson's disease (PD) is associated with the deposition of fibrillar aggregates of the protein α-synuclein (αS) in neurons. Intramolecular contacts between…”
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Journal Article -
3
Structural Characterization of Two Alternate Conformations in a Calbindin D 9k -Based Molecular Switch
Published in Biochemistry (Easton) (28-06-2011)Get full text
Journal Article -
4
The Cold Denatured State of the C-terminal Domain of Protein L9 Is Compact and Contains Both Native and Non-native Structure
Published in Journal of the American Chemical Society (07-04-2010)“…Cold denaturation is a general property of globular proteins, and the process provides insight into the origins of the cooperativity of protein folding and the…”
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Journal Article -
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Structural Characterization of Two Alternate Conformations in a Calbindin D9k-Based Molecular Switch
Published in Biochemistry (Easton) (28-06-2011)“…We have demonstrated that calbindin D9k can be converted into a calcium-sensing switch (calbindin-AFF) by duplicating the C-terminal half of the protein…”
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Journal Article -
6
The Approach to the Michaelis Complex in Lactate Dehydrogenase: The Substrate Binding Pathway
Published in Biophysical journal (01-09-2005)“…We examine here the dynamics of forming the Michaelis complex of the enzyme lactate dehydrogenase by characterizing the binding kinetics and thermodynamics of…”
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Journal Article -
7
The E46K Parkinson’s-linked mutation enhances C- to N-terminal contacts in α-synuclein
Published in Journal of molecular biology (05-04-2009)“…Parkinson’s disease (PD) is associated with the deposition of fibrillar aggregates of the protein α-synuclein (αS) in neurons. Intramolecular contacts between…”
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Journal Article -
8
Structural Transformations in the Dynamics of Michaelis Complex Formation in Lactate Dehydrogenase
Published in Biophysical journal (01-07-2005)“…The dynamical nature of the binding of a substrate surrogate to lactate dehydrogenase is examined on the nanoseconds to milliseconds timescale by laser-induced…”
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Journal Article -
9
Characterization of the substrate binding dynamics of lactate dehydrogenase
Published 01-01-2005“…We examine here the dynamics of forming the Michaelis complex of the enzyme lactate dehydrogenase (LDH) by characterizing the binding kinetics and…”
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Dissertation -
10
Characterization of the substrate binding dynamics of lactate dehydrogenase
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Dissertation