Search Results - "McClendon, Sebastian"

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  1. 1

    Charge neutralization and collapse of the C‐terminal tail of alpha‐synuclein at low pH by McClendon, Sebastian, Rospigliosi, Carla C., Eliezer, David

    Published in Protein science (01-07-2009)
    “…Alpha‐synuclein (αS) is the primary component of Lewy bodies, the pathological hallmark of Parkinson's Disease. Aggregation of αS is thought to proceed from a…”
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    Journal Article
  2. 2

    E46K Parkinson’s-Linked Mutation Enhances C-Terminal-to-N-Terminal Contacts in α-Synuclein by Rospigliosi, Carla C., McClendon, Sebastian, Schmid, Adrian W., Ramlall, Trudy F., Barré, Patrick, Lashuel, Hilal A., Eliezer, David

    Published in Journal of molecular biology (22-05-2009)
    “…Parkinson's disease (PD) is associated with the deposition of fibrillar aggregates of the protein α-synuclein (αS) in neurons. Intramolecular contacts between…”
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    Journal Article
  3. 3
  4. 4

    The Cold Denatured State of the C-terminal Domain of Protein L9 Is Compact and Contains Both Native and Non-native Structure by Shan, Bing, McClendon, Sebastian, Rospigliosi, Carla, Eliezer, David, Raleigh, Daniel P

    Published in Journal of the American Chemical Society (07-04-2010)
    “…Cold denaturation is a general property of globular proteins, and the process provides insight into the origins of the cooperativity of protein folding and the…”
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    Journal Article
  5. 5

    Structural Characterization of Two Alternate Conformations in a Calbindin D9k-Based Molecular Switch by Stratton, Margaret M, McClendon, Sebastian, Eliezer, David, Loh, Stewart N

    Published in Biochemistry (Easton) (28-06-2011)
    “…We have demonstrated that calbindin D9k can be converted into a calcium-sensing switch (calbindin-AFF) by duplicating the C-terminal half of the protein…”
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    Journal Article
  6. 6

    The Approach to the Michaelis Complex in Lactate Dehydrogenase: The Substrate Binding Pathway by McClendon, Sebastian, Zhadin, Nick, Callender, Robert

    Published in Biophysical journal (01-09-2005)
    “…We examine here the dynamics of forming the Michaelis complex of the enzyme lactate dehydrogenase by characterizing the binding kinetics and thermodynamics of…”
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    Journal Article
  7. 7

    The E46K Parkinson’s-linked mutation enhances C- to N-terminal contacts in α-synuclein by Rospigliosi, Carla C., McClendon, Sebastian, Schmid, Adrian W., Ramlall, Trudy F., Barré, Patrick, Lashuel, Hilal A., Eliezer, David

    Published in Journal of molecular biology (05-04-2009)
    “…Parkinson’s disease (PD) is associated with the deposition of fibrillar aggregates of the protein α-synuclein (αS) in neurons. Intramolecular contacts between…”
    Get full text
    Journal Article
  8. 8

    Structural Transformations in the Dynamics of Michaelis Complex Formation in Lactate Dehydrogenase by McClendon, Sebastian, Vu, Dung M., Clinch, Keith, Callender, Robert, Brian Dyer, R.

    Published in Biophysical journal (01-07-2005)
    “…The dynamical nature of the binding of a substrate surrogate to lactate dehydrogenase is examined on the nanoseconds to milliseconds timescale by laser-induced…”
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    Journal Article
  9. 9

    Characterization of the substrate binding dynamics of lactate dehydrogenase by McClendon, Sebastian

    Published 01-01-2005
    “…We examine here the dynamics of forming the Michaelis complex of the enzyme lactate dehydrogenase (LDH) by characterizing the binding kinetics and…”
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    Dissertation
  10. 10

    Characterization of the substrate binding dynamics of lactate dehydrogenase by McClendon, Sebastian

    “…We examine here the dynamics of forming the Michaelis complex of the enzyme lactate dehydrogenase (LDH) by characterizing the binding kinetics and…”
    Get full text
    Dissertation