Search Results - "McCleland, Mark"

Atezolizumab Plus Chemotherapy for First-Line Treatment of Nonsquamous NSCLC: Results From the Randomized Phase 3 IMpower132 Trial by Nishio, Makoto, Barlesi, Fabrice, West, Howard, Ball, Simon, Bordoni, Rodolfo, Cobo, Manuel, Longeras, Pascale Dubray, Goldschmidt, Jr, Jerome, Novello, Silvia, Orlandi, Francisco, Sanborn, Rachel E, Szalai, Zsuzsanna, Ursol, Grigoriy, Mendus, Diana, Wang, Lijia, Wen, Xiaohui, McCleland, Mark, Hoang, Tien, Phan, See, Socinski, Mark A

“…We report the final results of the phase 3 IMpower132 study evaluating atezolizumab plus carboplatin or cisplatin plus pemetrexed (APP) in patients with…”
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CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer by McCleland, Mark L, Mesh, Kathryn, Lorenzana, Edward, Chopra, Vivek S, Segal, Ehud, Watanabe, Colin, Haley, Benjamin, Mayba, Oleg, Yaylaoglu, Murat, Gnad, Florian, Firestein, Ron

“…Colon tumors arise in a stepwise fashion from either discrete genetic perturbations or epigenetic dysregulation. To uncover the key epigenetic regulators that…”
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Updated Overall Survival Analysis From IMpower110: Atezolizumab Versus Platinum-Based Chemotherapy in Treatment-Naive Programmed Death-Ligand 1-Selected NSCLC by Jassem, Jacek, de Marinis, Filippo, Giaccone, Giuseppe, Vergnenegre, Alain, Barrios, Carlos H, Morise, Masahiro, Felip, Enriqueta, Oprean, Cristina, Kim, Young-Chul, Andric, Zoran, Mocci, Simonetta, Enquist, Ida, Komatsubara, Kimberly, McCleland, Mark, Kuriki, Hiroshi, Villalobos, Monette, Phan, See, Spigel, David R, Herbst, Roy S

“…IMpower110 previously revealed significant overall survival (OS) benefit with atezolizumab versus chemotherapy in patients with treatment-naive EGFR- and…”
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Molecular determinants of response to PD-L1 blockade across tumor types by Banchereau, Romain, Leng, Ning, Zill, Oliver, Sokol, Ethan, Liu, Gengbo, Pavlick, Dean, Maund, Sophia, Liu, Li-Fen, Kadel, Edward, Baldwin, Nicole, Jhunjhunwala, Suchit, Nickles, Dorothee, Assaf, Zoe June, Bower, Daniel, Patil, Namrata, McCleland, Mark, Shames, David, Molinero, Luciana, Huseni, Mahrukh, Sanjabi, Shomyseh, Cummings, Craig, Mellman, Ira, Mariathasan, Sanjeev, Hegde, Priti, Powles, Thomas

“…Immune checkpoint inhibitors targeting the PD-1/PD-L1 axis lead to durable clinical responses in subsets of cancer patients across multiple indications,…”
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An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer by MCCLELAND, Mark L, ADLER, Adam S, BELVIN, Marcia, HATZIVASSILIOU, Georgia, BLACKWOOD, Elizabeth M, CORSON, Laura, EVANGELISTA, Marie, JIPING ZHA, FIRESTEIN, Ron, YONGLEI SHANG, HUNSAKER, Thomas, TRUONG, Tom, PETERSON, David, TORRES, Eric, LI LI, HALEY, Benjamin, STEPHAN, Jean-Philippe

“…Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive,…”
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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition by Boudreau, Aaron, Purkey, Hans E, Hitz, Anna, Robarge, Kirk, Peterson, David, Labadie, Sharada, Kwong, Mandy, Hong, Rebecca, Gao, Min, Del Nagro, Christopher, Pusapati, Raju, Ma, Shuguang, Salphati, Laurent, Pang, Jodie, Zhou, Aihe, Lai, Tommy, Li, Yingjie, Chen, Zhongguo, Wei, Binqing, Yen, Ivana, Sideris, Steve, McCleland, Mark, Firestein, Ron, Corson, Laura, Vanderbilt, Alex, Williams, Simon, Daemen, Anneleen, Belvin, Marcia, Eigenbrot, Charles, Jackson, Peter K, Malek, Shiva, Hatzivassiliou, Georgia, Sampath, Deepak, Evangelista, Marie, O'Brien, Thomas

“…The application of a potent lactate dehydrogenase (LDHA) inhibitor GNE-140 on pancreatic cancer cells revealed that resistance to GNE-140 is attributable to an…”
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Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung Adenocarcinomas by MCCLELAND, Mark L, ADLER, Adam S, JACKSON, Erica, FORREST, William F, FIRESTEIN, Ron, DEMING, Laura, COSINO, Ely, LEE, Leslie, BLACKWOOD, Elizabeth M, SOLON, Margaret, TAO, Janet, LI LI, SHAMES, David

“…This study is aimed to identify genes within the KRAS genomic amplicon that are both coupregulated and essential for cell proliferation when KRAS is amplified…”
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Clinical efficacy of atezolizumab plus bevacizumab and chemotherapy in KRAS-mutated non-small cell lung cancer with STK11, KEAP1, or TP53 comutations: subgroup results from the phase III IMpower150 trial by West, Howard Jack, McCleland, Mark, Cappuzzo, Federico, Reck, Martin, Mok, Tony SK, Jotte, Robert M, Nishio, Makoto, Kim, Eugene, Morris, Stefanie, Zou, Wei, Shames, David, Das Thakur, Meghna, Shankar, Geetha, Socinski, Mark A

“…BackgroundThe efficacy of atezolizumab (A) and/or bevacizumab (B) with carboplatin/paclitaxel (CP) chemotherapy was explored in the phase III, randomized…”
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An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth by Adler, Adam S, McCleland, Mark L, Yee, Sharon, Yaylaoglu, Murat, Hussain, Sofia, Cosino, Ely, Quinones, Gabriel, Modrusan, Zora, Seshagiri, Somasekar, Torres, Eric, Chopra, Vivek S, Haley, Benjamin, Zhang, Zemin, Blackwood, Elizabeth M, Singh, Mallika, Junttila, Melissa, Stephan, Jean-Philippe, Liu, Jinfeng, Pau, Gregoire, Fearon, Eric R, Jiang, Zhaoshi, Firestein, Ron

“…The spliceosome machinery is composed of multimeric protein complexes that generate a diverse repertoire of mRNA through coordinated splicing of heteronuclear…”
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CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency by Adler, Adam S, McCleland, Mark L, Truong, Tom, Lau, Shari, Modrusan, Zora, Soukup, Tim M, Roose-Girma, Merone, Blackwood, Elizabeth M, Firestein, Ron

“…CDK8 is a cyclin-dependent kinase that mediates transcriptional control of pathways linked to both cancer and stem cells. In this study, we show that CDK8 is…”
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Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis by McCleland, Mark L, Soukup, Tim M, Liu, Scot D, Esensten, Jonathan H, de Sousa e Melo, Felipe, Yaylaoglu, Murat, Warming, Soren, Roose-Girma, Merone, Firestein, Ron

“…CDK8 is a dissociable kinase module of the Mediator complex and has been shown to play an important role in transcriptional regulation in organisms as diverse…”
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Developmental Control of Late Replication and S Phase Length by Shermoen, Antony W., McCleland, Mark L., O'Farrell, Patrick H.

“…Fast, early embryonic cell cycles have correspondingly fast S phases. In early Drosophila embryos, forks starting from closely spaced origins replicate the…”
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Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade by Banchereau, Romain, Chitre, Avantika S., Scherl, Alexis, Wu, Thomas D., Patil, Namrata S., de Almeida, Patricia, Kadel, III, Edward E., Madireddi, Shravan, Au-Yeung, Amelia, Takahashi, Chikara, Chen, Ying-Jiun, Modrusan, Zora, McBride, Jacqueline, Nersesian, Rhea, El-Gabry, Ehab A., Robida, Mark D., Hung, Jeffrey C., Kowanetz, Marcin, Zou, Wei, McCleland, Mark, Caplazi, Patrick, Eshgi, Shadi Toghi, Koeppen, Hartmut, Hegde, Priti S., Mellman, Ira, Mathews, W. Rodney, Powles, Thomas, Mariathasan, Sanjeev, Grogan, Jane, O'Gorman, William E

“…BackgroundCD8+ tissue-resident memory T (TRM) cells, marked by CD103 (ITGAE) expression, are thought to actively suppress cancer progression, leading to the…”
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Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae by White, Forest M, Ficarro, Scott B, McCleland, Mark L, Stukenberg, P. Todd, Burke, Daniel J, Ross, Mark M, Shabanowitz, Jeffrey, Hunt, Donald F

“…Protein kinases are coded by more than 2,000 genes and thus constitute the largest single enzyme family in the human genome. Most cellular processes are in…”
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Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells by Koehler, Michael F. T, Bergeron, Philippe, Blackwood, Elizabeth M, Bowman, Krista, Clark, Kevin R, Firestein, Ron, Kiefer, James R, Maskos, Klaus, McCleland, Mark L, Orren, Linda, Salphati, Laurent, Schmidt, Steve, Schneider, Elisabeth V, Wu, Jiansheng, Beresini, Maureen H

“…Beginning with promiscuous COT inhibitors, which were found to inhibit CDK8, a series of 6-aza-benzothiophene containing compounds were developed into potent,…”
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Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer by Liu, Jinfeng, McCleland, Mark, Stawiski, Eric W., Gnad, Florian, Mayba, Oleg, Haverty, Peter M., Durinck, Steffen, Chen, Ying-Jiun, Klijn, Christiaan, Jhunjhunwala, Suchit, Lawrence, Michael, Liu, Hanbin, Wan, Yinan, Chopra, Vivek, Yaylaoglu, Murat B., Yuan, Wenlin, Ha, Connie, Gilbert, Houston N., Reeder, Jens, Pau, Gregoire, Stinson, Jeremy, Stern, Howard M., Manning, Gerard, Wu, Thomas D., Neve, Richard M., de Sauvage, Frederic J., Modrusan, Zora, Seshagiri, Somasekar, Firestein, Ron, Zhang, Zemin

“…Gastric cancer is the second leading cause of worldwide cancer mortality, yet the underlying genomic alterations remain poorly understood. Here we perform…”
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Comparison of SP142 and 22C3 Immunohistochemistry PD-L1 Assays for Clinical Efficacy of Atezolizumab in Non–Small Cell Lung Cancer: Results From the Randomized OAK Trial by Gadgeel, Shirish, Hirsch, Fred R., Kerr, Keith, Barlesi, Fabrice, Park, Keunchil, Rittmeyer, Achim, Zou, Wei, Bhatia, Namrata, Koeppen, Hartmut, Paul, Sarah M., Shames, David, Yi, Jing, Matheny, Christina, Ballinger, Marcus, McCleland, Mark, Gandara, David R.

“…•OAK subgroup analysis compared SP142 and 22C3 assays at defined programmed death ligand 1 thresholds.•Survival benefit of atezolizumab over docetaxel across…”
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RNAi of Mitotic Cyclins in Drosophila Uncouples the Nuclear and Centrosome Cycle by McCleland, Mark L., O'Farrell, Patrick H.

“…Successful cell duplication requires orderly progression through a succession of dramatic cell-cycle events. Disruption of this precise coupling can compromise…”
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IMpower010: Primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in resected stage IB-IIIA non-small cell lung cancer (NSCLC) by Wakelee, Heather A., Altorki, Nasser K., Zhou, Caicun, Csőszi, Tibor, Vynnychenko, Ihor O., Goloborodko, Oleksandr, Luft, Alexander, Akopov, Andrey, Martinez-Marti, Alex, Kenmotsu, Hirotsugu, Chen, Yuh-Min, Chella, Antonio, Sugawara, Shunichi, Gitlitz, Barbara J., Bennett, Elizabeth, Wu, Fan, Yi, Jing, Deng, Yu, McCleland, Mark, Felip, Enriqueta

“…Abstract only 8500 Background: Adjuvant platinum-based chemotherapy (chemo) provides only a modest 5-year survival benefit in fully resected, high-risk…”
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Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis by Kallio, Marko J, McCleland, Mark L, Stukenberg, P Todd, Gorbsky, Gary J

“…How kinetochores correct improper microtubule attachments and regulate the spindle checkpoint signal is unclear. In budding yeast, kinetochores harboring…”
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