Search Results - "McCleary‐Wheeler, Angela L."

A preoperative serum signature of CEA+/CA125+/CA19‐9 ≥ 1000 U/mL indicates poor outcome to pancreatectomy for pancreatic cancer by Liu, Liang, Xu, Huaxiang, Wang, Wenquan, Wu, Chuntao, Chen, Yong, Yang, Jingxuan, Cen, Putao, Xu, Jin, Liu, Chen, Long, Jiang, Guha, Sushovan, Fu, Deliang, Ni, Quanxing, Jatoi, Aminah, Chari, Suresh, McCleary‐Wheeler, Angela L., Fernandez‐Zapico, Martin E., Li, Min, Yu, Xianjun

“…Pancreatectomy is associated with significant morbidity and unpredictable outcome, with few diagnostic tools to determine, which patients gain the most benefit…”
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Evaluation of canonical Hedgehog signaling pathway inhibition in canine osteosarcoma by Baldanza, Vincent E, Rogic, Anita, Yan, Weiwei, Levine, Corri B, Levine, Roy A, Miller, Andrew D, McCleary-Wheeler, Angela L

“…Canine osteosarcoma (OSA), the most common canine primary bone malignancy, has a highly aggressive biologic behavior. Despite current standard of care…”
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Age at cancer diagnosis by breed, weight, sex, and cancer type in a cohort of more than 3,000 dogs: Determining the optimal age to initiate cancer screening in canine patients by Rafalko, Jill M, Kruglyak, Kristina M, McCleary-Wheeler, Angela L, Goyal, Vidit, Phelps-Dunn, Ashley, Wong, Lilian K, Warren, Chelsea D, Brandstetter, Gina, Rosentel, Michelle C, DiMarzio, Lauren, McLennan, Lisa M, O'Kell, Allison L, Cohen, Todd A, Grosu, Daniel S, Chibuk, Jason, Tsui, Dana W Y, Chorny, Ilya, Flory, Andi

“…The goal of cancer screening is to detect disease at an early stage when treatment may be more effective. Cancer screening in dogs has relied upon annual…”
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Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma by Peralta, Santiago, Duhamel, Gerald E., Katt, William P., Heikinheimo, Kristiina, Miller, Andrew D., Ahmed, Faraz, McCleary-Wheeler, Angela L., Grenier, Jennifer K.

“…Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA)…”
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Cancer detection in clinical practice and using blood‐based liquid biopsy: A retrospective audit of over 350 dogs by Flory, Andi, McLennan, Lisa, Peet, Betsy, Kroll, Marissa, Stuart, Deirdre, Brown, Devon, Stuebner, Kathy, Phillips, Brenda, Coomber, Brenda L., Woods, J. Paul, Miller, Mairin, Tripp, Chelsea D., Wolf‐Ringwall, Amber, Kruglyak, Kristina M., McCleary‐Wheeler, Angela L., Phelps‐Dunn, Ashley, Wong, Lilian K., Warren, Chelsea D., Brandstetter, Gina, Rosentel, Michelle C., DiMarzio, Lauren R., O'Kell, Allison L., Cohen, Todd A., Grosu, Daniel S., Chibuk, Jason, Tsui, Dana W. Y., Chorny, Ilya, Rafalko, Jill M.

“…Background Guidelines‐driven screening protocols for early cancer detection in dogs are lacking, and cancer often is detected at advanced stages…”
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Ultra‐frequent HRAS p.Q61R somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma by Peralta, Santiago, McCleary‐Wheeler, Angela L., Duhamel, Gerald E., Heikinheimo, Kristiina, Grenier, Jennifer K.

“…Ameloblastoma is a locally aggressive odontogenic tumour that occurs in humans and dogs. Most ameloblastomas (AM) in humans harbour mutually‐exclusive driving…”
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Aberrant signaling pathways in pancreatic cancer: A two compartment view by McCleary-Wheeler, Angela L., McWilliams, Robert, Fernandez-Zapico, Martin E.

“…Pancreatic cancer is a devastating disease with historically limited success in treatment and a poor prognosis. Pancreatic cancer appears to have a progressive…”
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The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism by Zheng, Xin, Vittar, Natalia B Rumie, Gai, Xiaohong, Fernandez-Barrena, Maite G, Moser, Catherine D, Hu, Chunling, Almada, Luciana L, McCleary-Wheeler, Angela L, Elsawa, Sherine F, Vrabel, Anne M, Shire, Abdirashid M, Comba, Andrea, Thorgeirsson, Snorri S, Kim, Youngsoo, Liu, Qingguang, Fernandez-Zapico, Martin E, Roberts, Lewis R

“…The role of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established, however the regulatory…”
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Editorial: Comparative Oncology-Advances in Veterinary Molecular Oncology by Meichner, Kristina, McCleary-Wheeler, Angela L, Mochizuki, Hiroyuki, Stokol, Tracy

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Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts by McGee-Lawrence, Meghan E, McCleary-Wheeler, Angela L, Secreto, Frank J, Razidlo, David F, Zhang, Minzhi, Stensgard, Bridget A, Li, Xiaodong, Stein, Gary S, Lian, Jane B, Westendorf, Jennifer J

“…Abstract Histone deacetylase (Hdac) inhibitors are used clinically to treat cancer and epilepsy. Although Hdac inhibition accelerates osteoblast maturation and…”
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Effects of neoadjuvant zoledronate and radiation therapy on cell survival, cell cycle distribution, and clinical status in canine osteosarcoma by Norquest, Carissa J, Rogic, Anita, Gimotty, Phyllis A, Maitz, Charles A, Rindt, Hansjorg, Ashworth, Hayley L, Bryan, Jeffrey N, Donnelly, Lindsay L, McCleary-Wheeler, Angela L, Flesner, Brian K

“…Zoledronic acid (ZOL) is a third-generation bisphosphonate with a higher affinity for bone resorption areas than earlier bisphosphonates (i.e., pamidronate,…”
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Detection of Age-Related Somatic Alterations in Canine Blood Using Next-Generation Sequencing-Based Liquid Biopsy: An Analysis of over 4800 Dogs by Kruglyak, Kristina M, O'Kell, Allison L, Cohen, Todd A, Marshall, Maggie A, Ruiz-Perez, Carlos A, Marass, Francesco, Tynan, John A, Hicks, Susan C, Lytle, Katherine M, Phelps-Dunn, Ashley, Brandstetter, Gina, Warren, Chelsea D, DiMarzio, Lauren R, Rosentel, Michelle C, Wong, Lilian K, McLennan, Lisa M, Rafalko, Jill M, Grosu, Daniel S, Chibuk, Jason, Chorny, Ilya, McCleary-Wheeler, Angela L, Flory, Andi, Tsui, Dana W Y

“…Age-related somatic genomic alterations in hematopoietic cell lines have been well characterized in humans; however, this phenomenon has not been well studied…”
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Metabolic Abnormalities Detected in Phase II Evaluation of Doxycycline in Dogs with Multicentric B-Cell Lymphoma by Hume, Kelly R, Sylvester, Skylar R, Borlle, Lucia, Balkman, Cheryl E, McCleary-Wheeler, Angela L, Pulvino, Mary, Casulo, Carla, Zhao, Jiyong

“…Doxycycline has antiproliferative effects in human lymphoma cells and in murine xenografts. We hypothesized that doxycycline would decrease canine lymphoma…”
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Barking up the right tree: advancing our understanding and treatment of lymphoma with a spontaneous canine model by Villarnovo, Dania, McCleary-Wheeler, Angela L, Richards, Kristy L

“…PURPOSE OF REVIEWSpontaneous lymphoma in pet dogs is increasingly recognized as an ideal model for studying the disease in humans and for developing new…”
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Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas by Shah, Shivem B., Carlson, Christopher R., Lai, Kristine, Zhong, Zhe, Marsico, Grazia, Lee, Katherine M., Félix Vélez, Nicole E., Abeles, Elisabeth B., Allam, Mayar, Hu, Thomas, Walter, Lauren D., Martin, Karen E., Gandhi, Khanjan, Butler, Scott D., Puri, Rishi, McCleary-Wheeler, Angela L., Tam, Wayne, Elemento, Olivier, Takata, Katsuyoshi, Steidl, Christian, Scott, David W., Fontan, Lorena, Ueno, Hideki, Cosgrove, Benjamin D., Inghirami, Giorgio, García, Andrés J., Coskun, Ahmet F., Koff, Jean L., Melnick, Ari, Singh, Ankur

“…Activated B-cell-like diffuse large B-cell lymphomas (ABC-DLBCLs) are characterized by constitutive activation of nuclear factor κB driven by the B-cell…”
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Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs by LeBlanc, Amy K, Mazcko, Christina N, Cherukuri, Aswini, Berger, Erika P, Kisseberth, William C, Brown, Megan E, Lana, Susan E, Weishaar, Kristen, Flesner, Brian K, Bryan, Jeffrey N, Vail, David M, Burton, Jenna H, Willcox, Jennifer L, Mutsaers, Anthony J, Woods, J Paul, Northrup, Nicole C, Saba, Corey, Curran, Kaitlin M, Leeper, Haley, Wilson-Robles, Heather, Wustefeld-Janssens, Brandan G, Lindley, Stephanie, Smith, Annette N, Dervisis, Nikolaos, Klahn, Shawna, Higginbotham, Mary Lynn, Wouda, Raelene M, Krick, Erika, Mahoney, Jennifer A, London, Cheryl A, Barber, Lisa G, Balkman, Cheryl E, McCleary-Wheeler, Angela L, Suter, Steven E, Martin, Olya, Borgatti, Antonella, Burgess, Kristine, Childress, Michael O, Fidel, Janean L, Allstadt, Sara D, Gustafson, Daniel L, Selmic, Laura E, Khanna, Chand, Fan, Timothy M

“…The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition of mTOR…”
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GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression by Tolosa, Ezequiel J, Fernandez-Barrena, Maite G, Iguchi, Eriko, McCleary-Wheeler, Angela L, Carr, Ryan M, Almada, Luciana L, Flores, Luis F, Vera, Renzo E, Alfonse, Germine W, Marks, David L, Hogenson, Tara L, Vrabel, Anne M, Horn, Isaac P, Koenig, Amanda N, Safgren, Stephanie L, Sigafoos, Ashley N, Erkan, Mert, Romecin-Duran, Paola A, Sarabia Gonzalez, Alejandro, Zhou, Bo, Javelaud, Delphine, Marsaud, Veronique, Graham, Rondell P, Mauviel, Alain, Elsawa, Sherine F, Fernandez-Zapico, Martin E

“…The Hedgehog-regulated transcription factors GLI1 and GLI2 play overlapping roles in development and disease; however, the mechanisms underlying their…”
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TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ by McCleary-Wheeler, Angela L, Paradise, Brooke D, Almada, Luciana L, Carlson, Annika J, Marks, David L, Vrabel, Anne, Vera, Renzo E, Sigafoos, Ashley N, Olson, Rachel L, Fernandez-Zapico, Martin E

“…Abstract The modulation of GLI2, an oncogenic transcription factor commonly upregulated in cancer, is in many cases not due to genetic defects, suggesting…”
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Next-generation sequencing-based liquid biopsy may be used for detection of residual disease and cancer recurrence monitoring in dogs by McCleary-Wheeler, Angela L, Fiaux, Patrick C, Flesner, Brian K, Ruiz-Perez, Carlos A, McLennan, Lisa M, Tynan, John A, Hicks, Susan C, Rafalko, Jill M, Grosu, Daniel S, Chibuk, Jason, O'Kell, Allison L, Cohen, Todd A, Chorny, Ilya, Tsui, Dana W Y, Kruglyak, Kristina M, Flory, Andi

“…The purpose of this study was to evaluate the performance of a next-generation sequencing-based liquid biopsy test for cancer monitoring in dogs. Pre- and…”
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Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis by McCleary-Wheeler, Angela L, Lomberk, Gwen A, Weiss, Frank U, Schneider, Günter, Fabbri, Muller, Poshusta, Tara L, Dusetti, Nelson J, Baumgart, Sandra, Iovanna, Juan L, Ellenrieder, Volker, Urrutia, Raul, Fernandez-Zapico, Martin E

“…Highlights ► Epigenetics regulates gene expression by a mechanism unrelated to DNA sequence changes. ► Epigenetic events are involved in promotion and…”
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