Search Results - "McCleary, Scott"

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway by Schweighoffer, Edina, Vanes, Lesley, Nys, Josquin, Cantrell, Doreen, McCleary, Scott, Smithers, Nicholas, Tybulewicz, Victor L.J.

“…Follicular B cell survival requires signaling from BAFFR, a receptor for BAFF and the B cell antigen receptor (BCR). This “tonic” BCR survival signal is…”
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Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression by Jones, Katherine L, Beaumont, Dominic M, Bernard, Sharon G, Bit, Rino A, Campbell, Simon P, Chung, Chun-Wa, Cutler, Leanne, Demont, Emmanuel H, Dennis, Kate, Gordon, Laurie, Gray, James R, Haase, Michael V, Lewis, Antonia J, McCleary, Scott, Mitchell, Darren J, Moore, Susanne M, Parr, Nigel, Robb, Olivia J, Smithers, Nicholas, Soden, Peter E, Suckling, Colin J, Taylor, Simon, Walker, Ann L, Watson, Robert J, Prinjha, Rab K

“…The functions of the bromodomain and extra terminal (BET) family of proteins have been implicated in a wide range of diseases, particularly in the oncology and…”
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Evaluation of gabapentin and S-(+)-3-isobutylgaba in a rat model of postoperative pain by Field, M J, Holloman, E F, McCleary, S, Hughes, J, Singh, L

“…Gabapentin and S-(+)-3-isobutylgaba are anticonvulsant agents that selectively interact with the alpha2delta subunit of voltage-dependent calcium channels…”
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Progression and variability of TNBS colitis‐associated inflammation in rats assessed by contrast‐enhanced and T2‐weighted MRI by Pohlmann, Andreas, Tilling, Lorna C., Robinson, Alison, Woolmer, Olga, McCleary, Scott, Kruidenier, Laurens, Warnock, Linda C., Lewis, Huw D., Hobson, Anthony R., James, Michael F.

“…Background: A common feature of preclinical models of colitis is that the time‐course, magnitude, and persistence of inflammation vary considerably within the…”
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Utilization of an Intramolecular Hydrogen Bond To Increase the CNS Penetration of an NK1 Receptor Antagonist by Ashwood, Valerie A, Field, Mark J, Horwell, David C, Julien-Larose, Christine, Lewthwaite, Russell A, McCleary, Scott, Pritchard, Martyn C, Raphy, Jenny, Singh, Lakhbir

“…This paper describes the synthesis and physical and biological effects of introducing different substituents at the α-position of the tryptophan containing…”
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Automated reconstruction of cast-off blood spatter patterns based on Euclidean geometry and statistical likelihood by McCleary, Scott, Liscio, Eugene, De Brabanter, Kris, Attinger, Daniel

“…•Cast-off spatter pattern reconstruction method based on Euclidian geometry.•Reconstruction of weapon motion is represented as three-dimensional region of…”
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Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival by Ackermann, Jochen A, Nys, Josquin, Schweighoffer, Edina, McCleary, Scott, Smithers, Nicholas, Tybulewicz, Victor L J

“…Signals from the BCR are required for Ag-specific B cell recruitment into the immune response. Binding of Ag to the BCR induces phosphorylation of immune…”
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Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A) by Seal, Jonathan, Lamotte, Yann, Donche, Frédéric, Bouillot, Anne, Mirguet, Olivier, Gellibert, Françoise, Nicodeme, Edwige, Krysa, Gael, Kirilovsky, Jorge, Beinke, Soren, McCleary, Scott, Rioja, Inma, Bamborough, Paul, Chung, Chun-Wa, Gordon, Laurie, Lewis, Toni, Walker, Ann L., Cutler, Leanne, Lugo, David, Wilson, David M., Witherington, Jason, Lee, Kevin, Prinjha, Rab K.

“…A novel series of quinoline isoxazole BET family bromodomain inhibitors are discussed. Crystallography is used to illustrate binding modes and rationalize…”
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Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening by Wellaway, Christopher R, Amans, Dominique, Bamborough, Paul, Barnett, Heather, Bit, Rino A, Brown, Jack A, Carlson, Neil R, Chung, Chun-wa, Cooper, Anthony W. J, Craggs, Peter D, Davis, Robert P, Dean, Tony W, Evans, John P, Gordon, Laurie, Harada, Isobel L, Hirst, David J, Humphreys, Philip G, Jones, Katherine L, Lewis, Antonia J, Lindon, Matthew J, Lugo, Dave, Mahmood, Mahnoor, McCleary, Scott, Medeiros, Patricia, Mitchell, Darren J, O’Sullivan, Michael, Le Gall, Armelle, Patel, Vipulkumar K, Patten, Chris, Poole, Darren L, Shah, Rishi R, Smith, Jane E, Stafford, Kayleigh A. J, Thomas, Pamela J, Vimal, Mythily, Wall, Ian D, Watson, Robert J, Wellaway, Natalie, Yao, Gang, Prinjha, Rab K

“…The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize…”
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Design, Synthesis, and Characterization of I‑BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate by Humphreys, Philip G, Atkinson, Stephen J, Bamborough, Paul, Bit, Rino A, Chung, Chun-wa, Craggs, Peter D, Cutler, Leanne, Davis, Rob, Ferrie, Alan, Gong, GangLi, Gordon, Laurie J, Gray, Matthew, Harrison, Lee A, Hayhow, Thomas G, Haynes, Andrea, Henley, Nick, Hirst, David J, Holyer, Ian D, Lindon, Matthew J, Lovatt, Cerys, Lugo, David, McCleary, Scott, Molnar, Judit, Osmani, Qendresa, Patten, Chris, Preston, Alex, Rioja, Inmaculada, Seal, Jonathan T, Smithers, Nicholas, Sun, Fenglai, Tang, Dalin, Taylor, Simon, Theodoulou, Natalie H, Thomas, Clare, Watson, Robert J, Wellaway, Christopher R, Zhu, Linrong, Tomkinson, Nicholas C. O, Prinjha, Rab K

“…Through regulation of the epigenome, the bromodomain and extra terminal (BET) family of proteins represent important therapeutic targets for the treatment of…”
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Involvement of the central tachykinin NK1 receptor during maintenance of mechanical hypersensitivity induced by diabetes in the rat by Field, M J, McCleary, S, Boden, P, Suman-Chauhan, N, Hughes, J, Singh, L

“…Our study examines the role of central and peripheral neurokinin1 (NK1) receptors in diabetes-induced mechanical hypersensitivity. Glycine, N, N-dimethyl-,…”
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Identification of 5‐HT2C mediated mechanisms involved in urethral sphincter reflexes in a guinea‐pig model of urethral function by Conlon, Kelly, Miner, Wes, McCleary, Scott, McMurray, Gordon

“…What's known on the subject? and What does the study add? Preclinically, studies investigating urethral function have shown that the clinical benefit of agents…”
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Identification of 5‐HT 2C mediated mechanisms involved in urethral sphincter reflexes in a guinea‐pig model of urethral function by Conlon, Kelly, Miner, Wes, McCleary, Scott, McMurray, Gordon

“…What's known on the subject? and What does the study add? Preclinically, studies investigating urethral function have shown that the clinical benefit of agents…”
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Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors by Garton, Neil S., Barker, Michael D., Davis, Rob P., Douault, Clement, Hooper-Greenhill, Edward, Jones, Emma, Lewis, Huw D., Liddle, John, Lugo, Dave, McCleary, Scott, Preston, Alex G.S., Ramirez-Molina, Cesar, Neu, Margarete, Shipley, Tracy J., Somers, Don O., Watson, Robert J., Wilson, David M.

“…[Display omitted] The optimisation of the azanaphthyridine series of Spleen Tyrosine Kinase inhibitors is described. The medicinal chemistry strategy was…”
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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor by Liddle, John, Atkinson, Francis L., Barker, Michael D., Carter, Paul S., Curtis, Neil R., Davis, Rob P., Douault, Clement, Dickson, Marion C., Elwes, Dorothy, Garton, Neil S., Gray, Matthew, Hayhow, Thomas G., Hobbs, Clare I., Jones, Emma, Leach, Stuart, Leavens, Karen, Lewis, Huw D., McCleary, Scott, Neu, Margarete, Patel, Vipulkumar K., Preston, Alex G.S., Ramirez-Molina, Cesar, Shipley, Tracy J., Skone, Philip A., Smithers, Nick, Somers, Donald O., Walker, Ann L., Watson, Robert J., Weingarten, Gordon G.

“…The lead optimisation of the diaminopyrimidine carboxamide series of spleen tyrosine kinase inhibitors is described. The medicinal chemistry strategy was…”
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Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat by Field, M J, McCleary, S, Hughes, J, Singh, L

“…A single injection of streptozocin (50 mg/kg, i.p.) led to the development of static and dynamic allodynia in the rat. The two responses were detected,…”
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Identification of 5-HT(2C) mediated mechanisms involved in urethral sphincter reflexes in a guinea-pig model of urethral function by Conlon, Kelly, Miner, Wes, McCleary, Scott, McMurray, Gordon

“…Preclinically, studies investigating urethral function have shown that the clinical benefit of agents such as duloxetine may partly reflect increases in…”
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Ovariohysterectomy in the rat: a model of surgical pain for evaluation of pre-emptive analgesia? by Gonzalez, Maria Isabel, Field, Mark John, Bramwell, Steve, McCleary, Scott, Singh, Lakhbir

“…Ovariohysterectomy in the rat led to the induction of abdominal postures and referred mechanical allodynia in the hind paws. The latter was differentiated into…”
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Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain by Field, M J, Carnell, A J, Gonzalez, M I, McCleary, S, Oles, R J, Smith, R, Hughes, J, Singh, L

“…Enadoline is a highly selective and potent kappa-opioid receptor agonist. This report describes and compares the activities of enadoline and morphine in a rat…”
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Utilization of an Intramolecular Hydrogen Bond To Increase the CNS Penetration of an NK 1 Receptor Antagonist by Ashwood, Valerie A., Field, Mark J., Horwell, David C., Julien-Larose, Christine, Lewthwaite, Russell A., McCleary, Scott, Pritchard, Martyn C., Raphy, Jenny, Singh, Lakhbir

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