Search Results - "McClay, J L"

The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process by Abudahab, Sara, Price, E. T., Dozmorov, M. G., Deshpande, L. S., McClay, J. L.

“…The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, classically associated with the regulation of xenobiotic metabolism in response…”
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Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics by McClay, J L, Adkins, D E, Åberg, K, Stroup, S, Perkins, D O, Vladimirov, V I, Lieberman, J A, Sullivan, P F, van den Oord, E J C G

“…Schizophrenia is an often devastating neuropsychiatric illness. Understanding the genetic variation affecting response to antipsychotics is important to…”
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Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs by Adkins, D E, Åberg, K, McClay, J L, Bukszár, J, Zhao, Z, Jia, P, Stroup, T S, Perkins, D, McEvoy, J P, Lieberman, J A, Sullivan, P F, van den Oord, E J C G

“…Understanding individual differences in the susceptibility to metabolic side effects as a response to antipsychotic therapy is essential to optimize the…”
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Pharmacogenomic study of side-effects for antidepressant treatment options in STARD by Clark, S L, Adkins, D E, Aberg, K, Hettema, J M, McClay, J L, Souza, R P, van den Oord, E J C G

“…Understanding individual differences in susceptibility to antidepressant therapy side-effects is essential to optimize the treatment of depression. We…”
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Genome-wide association study of antipsychotic-induced QTc interval prolongation by Åberg, K, Adkins, D E, Liu, Y, McClay, J L, Bukszár, J, Jia, P, Zhao, Z, Perkins, D, Stroup, T S, Lieberman, J A, Sullivan, P F, van den Oord, E J C G

“…QT prolongation is associated with increased risk of cardiac arrhythmias. Identifying the genetic variants that mediate antipsychotic-induced prolongation may…”
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Behavioral metabolomics analysis identifies novel neurochemical signatures in methamphetamine sensitization by Adkins, D. E., McClay, J. L., Vunck, S. A., Batman, A. M., Vann, R. E., Clark, S. L., Souza, R. P., Crowley, J. J., Sullivan, P. F., van den Oord, E. J. C. G., Beardsley, P. M.

“…Behavioral sensitization has been widely studied in animal models and is theorized to reflect neural modifications associated with human psychostimulant…”
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Genome-wide pharmacogenomic study of citalopram-induced side effects in STARD by Adkins, D E, Clark, S L, Åberg, K, Hettema, J M, Bukszár, J, McClay, J L, Souza, R P, van den Oord, E J C G

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Catechol-O-methyltransferase and the clinical features of psychosis by McClay, J.L., Fanous, A., van den Oord, E.J.C.G., Webb, B.T., Walsh, D., O'Neill, F.A., Kendler, K.S., Chen, X.

“…A functional polymorphism (Val‐158‐Met) at the Catechol‐O‐methyltransferase (COMT) locus has been identified as a potential etiological factor in…”
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Split genes uncovered through science fusion by McClay, J L, van den Oord, E J C G

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Genome-wide pharmacogenomic study of citalopram-induced side effects in STARD by Adkins, D E, Clark, S L, Åberg, K, Hettema, J M, Bukszár, J, McClay, J L, Souza, R P, van den Oord, E J C G

“…Affecting about 1 in 12 Americans annually, depression is a leading cause of the global disease burden. While a range of effective antidepressants are now…”
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Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults by Aberg, Karolina A, McClay, Joseph L, Nerella, Srilaxmi, Clark, Shaunna, Kumar, Gaurav, Chen, Wenan, Khachane, Amit N, Xie, Linying, Hudson, Alexandra, Gao, Guimin, Harada, Aki, Hultman, Christina M, Sullivan, Patrick F, Magnusson, Patrik K E, van den Oord, Edwin J C G

“…Epigenetic studies present unique opportunities to advance schizophrenia research because they can potentially account for many of its clinical features and…”
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A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects by McClay, Joseph L, Aberg, Karolina A, Clark, Shaunna L, Nerella, Srilaxmi, Kumar, Gaurav, Xie, Lin Y, Hudson, Alexandra D, Harada, Aki, Hultman, Christina M, Magnusson, Patrik K E, Sullivan, Patrick F, Van Den Oord, Edwin J C G

“…The central importance of epigenetics to the aging process is increasingly being recognized. Here we perform a methylome-wide association study (MWAS) of aging…”
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High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction by McClay, Joseph L, Shabalin, Andrey A, Dozmorov, Mikhail G, Adkins, Daniel E, Kumar, Gaurav, Nerella, Srilaxmi, Clark, Shaunna L, Bergen, Sarah E, Hultman, Christina M, Magnusson, Patrik K E, Sullivan, Patrick F, Aberg, Karolina A, van den Oord, Edwin J C G

“…Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to…”
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A comprehensive family-based replication study of schizophrenia genes by Aberg, Karolina A, Liu, Youfang, Bukszár, Jozsef, McClay, Joseph L, Khachane, Amit N, Andreassen, Ole A, Blackwood, Douglas, Corvin, Aiden, Djurovic, Srdjan, Gurling, Hugh, Ophoff, Roel, Pato, Carlos N, Pato, Michele T, Riley, Brien, Webb, Todd, Kendler, Kenneth, O'Donovan, Mick, Craddock, Nick, Kirov, George, Owen, Mike, Rujescu, Dan, St Clair, David, Werge, Thomas, Hultman, Christina M, Delisi, Lynn E, Sullivan, Patrick, van den Oord, Edwin J

“…Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the specific genetic variants and pathways that increase susceptibility to SCZ is…”
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Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk by Xia, Hanzhang, Jahr, Fay M, Kim, Nak-Kyeong, Xie, Linying, Shabalin, Andrey A, Bryois, Julien, Sweet, Douglas H, Kronfol, Mohamad M, Palasuberniam, Preetha, McRae, MaryPeace, Riley, Brien P, Sullivan, Patrick F, van den Oord, Edwin J, McClay, Joseph L

“…Abstract The transcription factor 4 (TCF4) locus is a robust association finding with schizophrenia (SCZ), but little is known about the genes regulated by the…”
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Genome-Wide Pharmacogenomic Study of Neurocognition As an Indicator of Antipsychotic Treatment Response in Schizophrenia by MCCLAY, Joseph L, ADKINS, Daniel E, BEARDSLEY, Patrick M, LIEBERMAN, Jeffrey A, SULLIVAN, Patrick F, VAN DEN OORD, Edwin Jcg, BERG, Karolina A, BUKSZAR, Jozsef, KHACHANE, Amit N, KEEFE, Richard Se, PERKINS, Diana O, MCEVOY, Joseph P, STROUP, T. Scott, VANN, Robert E

“…Neurocognitive deficits are a core feature of schizophrenia and, therefore, represent potentially critical outcome variables for assessing antipsychotic…”
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Genomewide Association Study of Movement-Related Adverse Antipsychotic Effects by Åberg, Karolina, Adkins, Daniel E, Bukszár, József, Webb, Bradley T, Caroff, Stanley N, Miller, Del D, Sebat, Jonathan, Stroup, Scott, Fanous, Ayman H, Vladimirov, Vladimir I, McClay, Joseph L, Lieberman, Jeffrey A, Sullivan, Patrick F, van den Oord, Edwin J.C.G

“…Background Understanding individual differences in the development of extrapyramidal side effects (EPS) as a response to antipsychotic therapy is essential to…”
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Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment by Clark, Shaunna L, Souza, Renan P, Adkins, Daniel E, Åberg, Karolina, Bukszár, József, McClay, Joseph L, Sullivan, Patrick F, van den Oord, Edwin J.C.G

“…OBJECTIVETo examine the unique and congruent findings between multiple raters in a genome-wide association study (GWAS) in the context of understanding…”
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SNP-based analysis of neuroactive ligand–receptor interaction pathways implicates PGE2 as a novel mediator of antipsychotic treatment response: Data from the CATIE study by Adkins, Daniel E, Khachane, Amit N, McClay, Joseph L, Åberg, Karolina, Bukszár, Jozsef, Sullivan, Patrick F, van den Oord, Edwin J.C.G

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MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples by Aberg, Karolina A, McClay, Joseph L, Nerella, Srilaxmi, Xie, Lin Y, Clark, Shaunna L, Hudson, Alexandra D, Bukszár, Jozsef, Adkins, Daniel, Hultman, Christina M, Sullivan, Patrick F, Magnusson, Patrik K E, van den Oord, Edwin J C G

“…We studied the use of methyl-CpG binding domain (MBD) protein-enriched genome sequencing (MBD-seq) as a cost-effective screening tool for methylome-wide…”
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