Search Results - "McClay, DR"

A Genomic Regulatory Network for Development by Davidson, Eric H., Rast, Jonathan P., Oliveri, Paola, Ransick, Andrew, Calestani, Cristina, Yuh, Chiou-Hwa, Minokawa, Takuya, Amore, Gabriele, Hinman, Veronica, Arenas-Mena, César, Otim, Ochan, Brown, C. Titus, Livi, Carolina B., Lee, Pei Yun, Revilla, Roger, Rust, Alistair G., Pan, Zheng jun, Schilstra, Maria J., Peter J. C. Clarke, Arnone, Maria I., Rowen, Lee, Cameron, R. Andrew, McClay, David R., Hood, Leroy, Bolouri, Hamid

“…Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and…”
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Regulatory Gene Networks and the Properties of the Developmental Process by Davidson, Eric H., McClay, David R., Hood, Leroy

“…Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription…”
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p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos by Bradham, Cynthia A, McClay, David R

“…Most eggs in the animal kingdom establish a primary, animal-vegetal axis maternally, and specify the remaining two axes during development. In sea urchin…”
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Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo by Logan, C Y, Miller, J R, Ferkowicz, M J, McClay, D R

“…Beta-catenin is thought to mediate cell fate specification events by localizing to the nucleus where it modulates gene expression. To ask whether beta-catenin…”
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Activation of pmar1 controls specification of micromeres in the sea urchin embryo by Oliveri, Paola, Davidson, Eric H, McClay, David R

“…pmar1 is a transcription factor in the paired class homeodomain family that was identified and found to be transcribed in micromeres beginning at the fourth…”
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A Provisional Regulatory Gene Network for Specification of Endomesoderm in the Sea Urchin Embryo by Davidson, Eric H., Rast, Jonathan P., Oliveri, Paola, Ransick, Andrew, Calestani, Cristina, Yuh, Chiou-Hwa, Minokawa, Takuya, Amore, Gabriele, Hinman, Veronica, Arenas-Mena, César, Otim, Ochan, Brown, C.Titus, Livi, Carolina B., Lee, Pei Yun, Revilla, Roger, Schilstra, Maria J., Clarke, Peter J.C., Rust, Alistair G., Pan, Zhengjun, Arnone, Maria I., Rowen, Lee, Cameron, R.Andrew, McClay, David R., Hood, Leroy, Bolouri, Hamid

“…We present the current form of a provisional DNA sequence-based regulatory gene network that explains in outline how endomesodermal specification in the sea…”
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Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development by Croce, Jenifer, Duloquin, Louise, Lhomond, Guy, McClay, David R, Gache, Christian

“…Wnt signaling pathways play key roles in numerous developmental processes both in vertebrates and invertebrates. Their signals are transduced by Frizzled…”
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Nuclear β-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages by Wikramanayake, Athula H., Peterson, Robert, Chen, Jing, Huang, Ling, Bince, Joanna M., McClay, David R., Klein, William H.

“…The entry of β‐catenin into vegetal cell nuclei beginning at the 16‐cell stage is one of the earliest known molecular asymmetries seen along the animal–vegetal…”
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LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo by Sherwood, D R, McClay, D R

“…Cell-cell interactions are thought to regulate the differential specification of secondary mesenchyme cells (SMCs) and endoderm in the sea urchin embryo. The…”
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The Role of Brachyury (T) during Gastrulation Movements in the Sea Urchin Lytechinus variegatus by Gross, Jeffrey M., McClay, David R.

“…The studies described here sought to identify and characterize genes involved in the gastrulation and morphogenetic movements that occur during sea urchin…”
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The canonical Wnt pathway in embryonic axis polarity by Croce, Jenifer C., McClay, David R.

“…The canonical Wnt pathway plays crucial roles in multiple developmental processes, including in axis specification. Throughout the animal kingdom, this pathway…”
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SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis by Otim, Ochan, Amore, Gabriele, Minokawa, Takuya, McClay, David R., Davidson, Eric H.

“…The Strongylocentrotus purpuratus hnf6 ( Sphnf6) gene encodes a new member of the ONECUT family of transcription factors. The expression of hnf6 in the…”
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RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation by Beane, Wendy S., Gross, Jeffrey M., McClay, David R.

“…During gastrulation, the archenteron is formed using cell shape changes, cell rearrangements, filopodial extensions, and convergent extension movements to…”
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LvGroucho and nuclear β-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo by Range, Ryan C., Venuti, Judith M., McClay, David R.

“…In the sea urchin embryo, specification of the endomesoderm is accomplished by the activity of a network of regulatory genes in the vegetal hemisphere, called…”
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Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks by Amore, Gabriele, Yavrouian, Robert G, Peterson, Kevin J, Ransick, Andrew, McClay, David R, Davidson, Eric H

“…The Spdeadringer (Spdri) gene encodes an ARID-class transcription factor not previously known in sea urchin embryos. We show that Spdri is a key player in two…”
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Characterization of the Role of Cadherin in Regulating Cell Adhesion during Sea Urchin Development by Miller, Jeffrey R., McClay, David R.

“…During development, the modulation of cadherin adhesive function is proposed to control various morphogenetic events including epithelial–mesenchymal…”
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The Role of Thin Filopodia in Motility and Morphogenesis by McClay, David R.

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Methods for embryo dissociation and analysis of cell adhesion by McClay, David R

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LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo by Sherwood, D R, McClay, D R

“…The molecular mechanisms guiding the positioning of the ectoderm-endoderm boundary along the animal-vegetal axis of the sea urchin embryo remain largely…”
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A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo by McClay, D R, Peterson, R E, Range, R C, Winter-Vann, A M, Ferkowicz, M J

“…At fourth cleavage of sea urchin embryos four micromeres at the vegetal pole separate from four macromeres just above them in an unequal cleavage. The…”
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