Search Results - "McClain, MT"

Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus by Arbuckle, Melissa R, McClain, Micah T, Rubertone, Mark V, Scofield, R. Hal, Dennis, Gregory J, James, Judith A, Harley, John B

“…In 130 military personnel, systemic lupus erythematosus (SLE) developed after blood samples had been stored in the U.S. Department of Defense Serum Repository…”
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Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry by James, Judith A, McClain, Micah T, Heinlen, Latisha D, Dennis, Gregory J, Roebuck, Jon, Harley, John B

“…The origins of autoimmunity in systemic lupus erythematosus (SLE) are thought to involve both genetic and environmental factors. To identify environmental…”
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Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus by James, JA, Kim-Howard, XR, Bruner, BF, Jonsson, MK, McClain, MT, Arbuckle, MR, Walker, C., Dennis, GJ, Merrill, JT, Harley, JB

“…Systemic lupus erythematosus (SLE) is a clinically diverse, complex autoimmune disease which may present with coincident onset of many criteria or slow,…”
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Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading by Hal Scofield, R., Kurien, Biji T., Ganick, Samantha, McClain, Micah T., Pye, Quentin, James, Judith A., Schneider, Rebecca I., Broyles, Robert H., Bachmann, Michael, Hensley, Kenneth

“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with autoantibodies as a near universal feature of the disease. The Ro ribonucleoprotein…”
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Anti-Sm Autoantibodies in Systemic Lupus Target Highly Basic Surface Structures of Complexed Spliceosomal Autoantigens by McClain, Micah T, Ramsland, Paul A, Kaufman, Kenneth M, James, Judith A

“…Autoantibodies directed against spliceosomal proteins are a common and specific feature of systemic lupus erythematosus. These autoantibodies target a…”
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Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1 by McClain, Micah T., Rapp, Erin C., Harley, John B., James, Judith A.

“…The spectrum of antibodies against Epstein‐Barr virus nuclear antigen‐1 (EBNA‐1) in patients with a recent history of infectious mononucleosis and nonaffected…”
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Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus by Arbuckle, M R, James, J A, Dennis, G J, Rubertone, M V, McClain, M T, Kim, X R, Harley, J B

“…The initial clinical course of systemic lupus erythematosus (SLE) is variable, ranging from relatively minor manifestations progressing over years to rapid…”
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Structural Availability Influences the Capacity of Autoantigenic Epitopes to Induce a Widespread Lupus-Like Autoimmune Response by McClain, Micah T., Lutz, Carol S., Kaufman, Kenneth M., Faig, Ofer Z., Gross, Timothy F., James, Judith A., Cooper, Max D.

“…A subset of lupus patients with severe nephritis and anti-nRNP reactivity produces autoantibodies primarily against two major epitopes of the nRNP A (also…”
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The Genes, Environment, and Host Immune Responses in the Etiology of Systemic Lupus Erythematosus by Harley, JB, Kelly, JA, McClain, MT, James, JA

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Selective Small Antigenic Structures are Capable of Inducing Widespread Autoimmunity which Closely Mimics the Humoral Fine Specificity of Human SLE by MCCLAIN, M. T., SCOFIELD, R. H., KURIEN, B. T., GROSS, T. F., JAMES, J. A.

“…Recent data have suggested that autoantibodies in lupus can progress from simple immunity against a few antigenic structures to a complex response against…”
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Anti-Ro and anti-nRNP response in unaffected family members of SLE patients by Heinlen, Latisha D, McClain, Micah T, Kim, Xana, Quintero, Del-Rio Ana I, James, Judith A, Harley, John B, Scofield, R Hal

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Lupus Autoantibodies Recognize the Product of an Alternative Open Reading Frame of SmB/B by Kaufman, Kenneth M., Kirby, Monica Y., McClain, Micah T., Harley, John B., James, Judith A.

“…An unusual feature of the gene for the spliceosomal protein SmB/B′ is the presence of an unusually long alternative open reading frame (aORF) which could…”
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Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA by Lutz, Carol S., McClain, Micah T., Harley, John B., James, Judith A.

“…The U1A (or nRNP A) protein is known to play a critical role in eukaryotic pre‐mRNA splicing and polyadenylation. Previous studies revealed that several mouse…”
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An altered immune response to Epstein‐Barr nuclear antigen 1 in pediatric systemic lupus erythematosus by McClain, Micah T., Poole, Brian D., Bruner, Benjamin F., Kaufman, Kenneth M., Harley, John B., James, Judith A.

“…Objective New examples support the concept that host immune responses to pathogenic organisms can act as the nidus for autoimmunity. Two such examples…”
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Side-chain Specificities and Molecular Modelling of Peptide Determinants for Two Anti-Sm B/B′ Autoantibodies by James, Judith A., McClain, Micah T., Koelsch, Gerald, Williams, David G., Harley, John B.

“…Autoantibodies binding the Sm B and B′ peptides (B/B′) are commonly associated with systemic lupus erythematosus in man and in MRLlpr/lprmice. The linear…”
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The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus by McClain, Micah T., Arbuckle, Melissa R., Heinlen, Latisha D., Dennis, Gregory J., Roebuck, Jon, Rubertone, Mark V., Harley, John B., James, Judith A.

“…Objective To determine whether antiphospholipid antibodies (aPL) occur before the diagnosis of systemic lupus erythematosus (SLE) and before initial clotting…”
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The role of Epstein-Barr Virus in systemic lupus erythematosus by McClain, Micah, T.

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