Search Results - "McClain, Donald"

Iron and Diabetes Risk by Simcox, Judith A., McClain, Donald A.

“…Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions—hereditary hemochromatosis and…”
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Iron and the Pathophysiology of Diabetes by Harrison, Alexandria V, Lorenzo, Felipe Ramos, McClain, Donald A

“…High iron is a risk factor for type 2 diabetes mellitus (T2DM) and affects most of its cardinal features: decreased insulin secretion, insulin resistance, and…”
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Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes by Fernández-Real, José Manuel, McClain, Donald, Manco, Melania

“…The bidirectional relationship between iron metabolism and glucose homeostasis is increasingly recognized. Several pathways of iron metabolism are modified…”
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Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis by Ahmadi, Shokouh, Razazan, Atefeh, Nagpal, Ravinder, Jain, Shalini, Wang, Bo, Mishra, Sidharth P, Wang, Shaohua, Justice, Jamie, Ding, Jingzhong, McClain, Donald A, Kritchevsky, Stephen B, Kitzman, Dalane, Yadav, Hariom

“…Abstract Aging-related illnesses are increasing and effective strategies to prevent and/or treat them are lacking. This is because of a poor understanding of…”
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Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces by Nagpal, Ravinder, Wang, Shaohua, Solberg Woods, Leah C, Seshie, Osborne, Chung, Stephanie T, Shively, Carol A, Register, Thomas C, Craft, Suzanne, McClain, Donald A, Yadav, Hariom

“…Gut microbiome plays a fundamental role in several aspects of host health and diseases. There has been an exponential surge in the use of animal models that…”
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116-LB: Interaction between Iron Stores and Metformin Action by MCCLAIN, DONALD A., USOH, CHINENYE O., LORENZO, FELIPE, HARRISON, ALEXANDRIA V.

“…The mechanism of action of MET (MET) remains controversial. MET induces an iron starvation response in yeast, so we hypothesized that tissue iron might…”
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223-LB: Interactive Effects of Dietary Iron and Chronic Hypoxia on Glucose Homeostasis in a T2D Mouse Model by HARRISON, ALEXANDRIA V., MCCLAIN, DONALD A., SINK, SANDY T., LORENZO, FELIPE

“…The micronutrient iron is a risk factor for type II diabetes (T2D) . The effects of iron are, in part, mediated by the iron-sensing hypoxia inducible factor…”
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A genetic mechanism for Tibetan high-altitude adaptation by Lorenzo, Felipe R, Huff, Chad, Myllymäki, Mikko, Olenchock, Benjamin, Swierczek, Sabina, Tashi, Tsewang, Gordeuk, Victor, Wuren, Tana, Ri-Li, Ge, McClain, Donald A, Khan, Tahsin M, Koul, Parvaiz A, Guchhait, Prasenjit, Salama, Mohamed E, Xing, Jinchuan, Semenza, Gregg L, Liberzon, Ella, Wilson, Andrew, Simonson, Tatum S, Jorde, Lynn B, Kaelin, William G, Koivunen, Peppi, Prchal, Josef T

“…Josef Prchal and colleagues identify a mutation in EGLN1 associated with adaptation to high altitude in Tibetan individuals. Their functional studies suggest a…”
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Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB by Gao, Yan, Liu, Jingfang, Bai, Zhenzhong, Sink, Sandy, Zhao, Chengyu, Lorenzo, Felipe Ramos, McClain, Donald A.

“…We previously reported that iron down-regulates transcription of the leptin gene by increasing occupancy of phosphorylated cAMP response element-binding…”
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Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice by Wang, Shaohua, Ahmadi, Shokouh, Nagpal, Ravinder, Jain, Shalini, Mishra, Sidharth P., Kavanagh, Kylie, Zhu, Xuewei, Wang, Zhan, McClain, Donald A., Kritchevsky, Stephen B., Kitzman, Dalane W., Yadav, Hariom

“…Increased inflammation associated with leaky gut is a major risk factor for morbidity and mortality in older adults; however, successful preventive and…”
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1309-P: Dietary Iron and Kidney Function in Youth and Young Adults with Type 1 Diabetes by CONWAY, REBECCA B., CRUME, TESSA L., PERNG, WEI, MCCLAIN, DONALD A., DABELEA, DANA

“…The association of markers of body iron stores with kidney disease in type 1 diabetes (T1D) is complex, with both positive and inverse relationships observed…”
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Adipocyte iron regulates adiponectin and insulin sensitivity by Gabrielsen, J Scott, Gao, Yan, Simcox, Judith A, Huang, Jingyu, Thorup, David, Jones, Deborah, Cooksey, Robert C, Gabrielsen, David, Adams, Ted D, Hunt, Steven C, Hopkins, Paul N, Cefalu, William T, McClain, Donald A

“…Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is…”
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Genetic determinants of Tibetan high-altitude adaptation by Simonson, Tatum S., McClain, Donald A., Jorde, Lynn B., Prchal, Josef T.

“…Some highland populations have genetic adaptations that enable their successful existence in a hypoxic environment. Tibetans are protected against many of the…”
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Diabetes and pancreatic cancer risk in a multiracial cohort by Conway, Rebecca B. N., Hudson, Alana G., Munro, Heather, Fu, David, McClain, Donald A., Blot, William J.

“…Aims To determine the relationship of diabetes with pancreatic cancer incidence among African American and Whites of similar socio‐economic status. Methods…”
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Adipocyte iron regulates leptin and food intake by Gao, Yan, Li, Zhonggang, Gabrielsen, J Scott, Simcox, Judith A, Lee, Soh-hyun, Jones, Deborah, Cooksey, Bob, Stoddard, Gregory, Cefalu, William T, McClain, Donald A

“…Dietary iron supplementation is associated with increased appetite. Here, we investigated the effect of iron on the hormone leptin, which regulates food intake…”
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214-LB: Plasma Proteomic Markers of Iron and Risk of Diabetes in a Biracial Cohort by CONWAY, REBECCA B., YOUNG, KENDRA, PRATTE, KATHERINE A., KINNEY, GREGORY L., AUSTIN, ERIN, LI, YISHA, BOWLER, RUSSEL, MCCLAIN, DONALD A., CRAPPO, JAMES

“…Higher levels of iron have been linked to increased diabetes risk among European and European American (EA) populations; whether this is true for other…”
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The Academic Learning Health System: A Framework for Integrating the Multiple Missions of Academic Medical Centers by Rosenthal, Gary E., McClain, Donald A., High, Kevin P., Easterling, Douglas, Sharkey, Angela, Wagenknecht, Lynne E., O’Byrne, Christopher, Woodside, Rachel, Houston, Thomas K.

“…The learning health system (LHS) has emerged over the past 15 years as a concept for improving health care delivery. Core aspects of the LHS concept…”
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Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway by Daniels, Marc C., McClain, Donald A., Crook, Errol D.

“…The hexosamine biosynthesis pathway (HBP) is hypothesized to mediate many of the adverse effects of hyperglycemia. We have shown previously that increased flux…”
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Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis by JINGYU HUANG, JONES, Deborah, BAI LUO, SANDERSON, Michael, SOTO, Jamie, DALE ABEL, E, COOKSEY, Robert C, MCCLAIN, Donald A

“…Excess tissue iron levels are a risk factor for diabetes, but the mechanisms underlying the association are incompletely understood. We previously published…”
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Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison by Drummond, Micah J, Addison, Odessa, Brunker, Lucille, Hopkins, Paul N, McClain, Donald A, LaStayo, Paul C, Marcus, Robin L

“…Reduced lean mass and physical function is a characteristic of frailty. However, it is currently unknown if proteolysis through the E3 ubiquitin ligases and…”
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