Search Results - "McCay, Paul B."

Characteristics of an oxidant formed during iron (II) autoxidation by Reinke, L A, Rau, J M, McCay, P B

“…When ethanol (100 mM) and the spin trapping agent DMPO were added to a solution of FeSO4 (0.1 mM) in phosphate buffer (40 mM), pH 7.4, the spectrum of the…”
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Direct Evidence That the Hydroxyl Radical Plays a Pathogenetic Role in Myocardial “Stunning” in the Conscious Dog and Demonstration That Stunning Can Be Markedly Attenuated Without Subsequent Adverse Effects by Sekili, Selim, McCay, Paul B, Li, Xiao-Ying, Zughaib, Marcel, Sun, Jian-Zhong, Tang, Liang, Thornby, John I, Bolli, Roberto

“…Recent studies suggest that the hydroxyl radical (·OH) plays a pathogenetic role in postischemic ventricular dysfunction (myocardial “stunning”). This concept,…”
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Spin trapping studies of alcohol-initiated radicals in rat liver: influence of dietary fat by Reinke, L A, McCay, P B

“…We conducted spin trapping experiments to test the effects of acute and chronic alcohol consumption in livers from rats that had been fed either high fat (35%…”
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Prevention of DMBA-induced rat mammary carcinomas comparing leuprolide, oophorectomy, and tamoxifen by HOLLINGSWORTH, A. B, LERNER, M. R, LIGHTFOOT, S. A, WILKERSON, K. B, HANAS, J. S, MCCAY, P. B, BRACKETT, D. J

“…Leuprolide, a gonadotropin releasing hormone agonist, is currently being evaluated in a pilot study of premenopausal women for the prevention of breast cancer…”
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Glutathionyl- and hydroxyl radical formation coupled to the redox transitions of 1,4-naphthoquinone bioreductive alkylating agents during glutathione two-electron reductive addition by Goin, J, Gibson, D D, McCay, P B, Cadenas, E

“…The kinetic parameters of the redox transitions subsequent to the two-electron transfer implied in the glutathione (GSH) reductive addition to 2- and…”
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GSH‐dependent inhibition of lipid peroxidation: Properties of a potent cytosolic system which protects cell membranes by Gibson, Donald D., Hawrylko, Josephine, McCay, Paul B.

“…Properties of a heat labile, nondialyzable cytosolic factor which prevents lipid peroxidation in membranous organelles are described. The factor is present in…”
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Lack of myocardial lipid peroxidation during acute reperfusion injury in perfused guinea pig hearts by Barrington, P L, Lai, E, McCay, P B

“…The aim was to test the hypothesis that free radical induced lipid peroxidation contributes to the arrhythmias and contractile changes associated with…”
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Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radical by Noguchi, T, Fong, K L, Lai, E K, Alexander, S S, King, M M, Olson, L, Poyer, J L, McCay, P B

“…Evidence is presented which demonstrates that the first polypeptide to disappear in liver microsomes of phenobarbital-induced rats treated with CC14 was the…”
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Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity by Fong, Kuo-Lan, McCay, Paul B., Poyer, J. Lee, Keele, Bernard B., Misra, Hara

“…Since evidence had been published that lysosomes are disrupted by a free radical-like agent produced during the oxidation of NADPH by liver microsomes, the…”
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Lipid peroxidation and the degradation of cytochrome P-450 heme by Levin, W, Lu, A Y, Jacobson, M, Kuntzman, R, Poyer, J L, McCay, P B

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Evidence that the effectiveness of antioxidants as inhibitors of 7,12-dimethylbenz(a) anthracene-induced mammary tumors is a function of dietary fat composition by McCay, P B, King, M M, Pitha, J V

“…A study of tumor incidence and tumor growth rates in 7,12-dimethylbenz(a)anthracene-treated female Sprague-Dawley rats fed different types and amounts of…”
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In vivo spin-trapping of radicals formed during halothane metabolism by Poyer, J L, McCay, P B, Weddle, C C, Downs, P E

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Effect of glutathione peroxidase activity on lipid peroxidation in biological membranes by McCray, P B, Gibson, D D, Fong, K L, Hornbrook, K R

“…Results are presented indicating that, although glutathione peroxidase activity inhibits lipid peroxidation in membranes, it does not appear to do so by…”
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Recurrent ischemia in the canine heart causes recurrent bursts of free radical production that have a cumulative effect on contractile function. A pathophysiological basis for chronic myocardial "stunning" by Bolli, R, Zughaib, M, Li, X Y, Tang, X L, Sun, J Z, Triana, J F, McCay, P B

“…Open-chest dogs (total number used, 117) underwent 10 5-min coronary occlusions (O) interspersed with 10 min of reperfusion (R). When systolic thickening…”
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Marked Reduction of Free Radical Generation and Contractile Dysfunction by Antioxidant Therapy Begun at the Time of Reperfusion Evidence That Myocardial "Stunning" Is a Manifestation of Reperfusion Injury by Bolli, Roberto, Jeroudi, Mohamed O, Patel, Bharat S, Aruoma, Okezie I, Halliwell, Barry, Lai, Edward K, McCay, Paul B

“…Recent evidence suggests that postischemic myocardial dysfunction (“stunning”) may be mediated by oxygen free radicals, but the exact time window during which…”
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Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids by Poyer, J. Lee, McCay, Paul B.

“…Fe 3+ was shown to be required for enzyme-catalyzed peroxidative chain-scission of polyunsaturated fatty acids of phospholipids in liver microsomal membranes…”
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Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids by Tam, Billy K., McCay, Paul B.

“…Transient formation of phospholipid peroxides was observed during the TPNH-dependent cleavage of phospholipid-bound polyunsaturated fatty acids in liver…”
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Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids by Pfeifer, Peter M., McCay, Paul B., With the technical assistance of Diana Coutee

“…These studies are part of an effort to determine how the activities of certain membrane-bound oxidoreductase systems affect the structure and function of the…”
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Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog by Bolli, R, Jeroudi, M.O, Patel, B.S, DuBose, C.M, Lai, E.K, Roberts, R, McCay, P.B

“…Electron paramagnetic resonance (EPR) spectroscopy was used to investigate whether (i) the free radicals produced in the ``stunned'' myocardium (myocardium…”
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Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids by Pfeifer, Peter M., McCay, Paul B., With the technical assistance of Diana Coutee

“…Evidence is given for the generation of a component having the properties of a free radical during the oxidation of TPNH by liver microsomes. The component is…”
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