Search Results - "McCay, J Ann"

Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice by Guo, T L, McCay, J A, Zhang, L X, Brown, R D, You, L, Karrow, N A, Germolec, D R, White, Jr, K L

“…The isoflavone genistein (4,7,4'-trihydroxyisoflavone) is a phytoestrogen found in high levels in soy products that has been associated with decreased…”
Get more information

Nonylphenol alters the activity of splenic NK cells and the numbers of leukocyte subpopulations in Sprague–Dawley rats: a two-generation feeding study by Karrow, N.A, Guo, T.L, Delclos, K.B, Newbold, R.R, Weis, C, Germolec, D.R, White, K.L, McCay, J.Ann

“…Nonylphenol (NP) has been identified at low levels in surface waters throughout North America. This industrial chemical is primarily used for the production of…”
Get full text

Immunotoxicity evaluation of nelfinavir in rats by Burns-Naas, Leigh Ann, White, Jr, Kimber L, McCay, J Ann, Ivett, James, Webber, Stephanie, Zorbas, Mark

“…The objective of these investigations was to determine whether exposure to the HIV-1 protease inhibitor nelfinavir compromises immune function in Sprague…”
Get more information

DELAYED ASSESSMENT OF IMMUNOLOGICAL FUNCTION ALLOWING FOR TRANSPORTATION OF LYMPHOID TISSUES TO DISTANT LABORATORY SITES by Woolhiser, Michael, Ann, Mccay

“…The immune system is a frequent target for chemical toxicity. Accordingly, a number of immunotoxicological assays are performed during the research and…”
Get full text

Toxicology and Humoral Immunity Assessment of Decamethylcyclopentasiloxane (D5) Following a 1-Month Whole Body Inhalation Exposure in Fischer 344 Rats by Burns-Naas, Leigh Ann, Mast, Richard W., Klykken, Paal C., McCay, J. Ann, White, Kimber L., Mann, Peter C., Naas, Dennis J.

“…D5 is a low-molecular-weight cyclic siloxane used for industrial and consumer product applications. The objective of the present study was to assess potential…”
Get full text

Contact hypersensitivity response to glutaraldehyde in guinea pigs and mice by Stern, M L, Holsapple, M P, McCay, J A, Munson, A E

“…Glutaraldehyde has a wide spectrum of uses which can result in dermal contact with the agent. The low number of reports of hypersensitive reactions to…”
Get more information

Effects of pentachlorophenol on the in vitro and in vivo antibody response by Holsapple, M P, McNerney, P J, McCay, J A

“…The effects of pentachlorophenol (PCP) on selected parameters reflecting immunocompetence of female B6C3F1 mice were measured following subchronic exposure (14…”
Get more information

Correlation of Suppressed Natural Killer Cell Activity with Altered Host Resistance Models in B6C3F1 Mice by Wilson, Susan D., McCay, J.Ann, Butterworth, Leon F., Munson, Albert E., White, Kimber L.

“…A number of methods have been developed to assess the impact of a xenobiotic on the various components of the immune system. For risk analysis, it is necessary…”
Get full text

Influence of MHC background on the antibody response to detergent enzymes in the mouse intranasal test by SARLO, Katherine, PARRI, Jennifer S, CLARK, Edwin D, HORN, Patricia A, ROBINSON, Michael K, MCCAY, J. Ann, PEACHEE, Vanessa L, VELOSO, Yvonne L, WHITE, Kimber L

“…The mouse intranasal test (MINT) was developed to assess the immunogenic potential of detergent enzymes. The BDF1 mouse (H-2(b/d)), a cross of C57Bl/6 (H-2(b))…”
Get full text

Immunotoxicologic studies with CI-959, a novel benzothiophene cell activation inhibitor by Bleavins, Michael R., De La Iglesia, Felix A., Mccay, J.Ann, White, kimber L., Munson, Albert E.

“…CI-959 is an orally effective inhibitor of cellular activation in both in vitro and animal models. To assess the effects of CI-959 on immune function, male…”
Get full text

IMMUNOTOXICITY OF SODIUM BROMATE IN FEMALE B6C3F1 MICE: A 28-DAY DRINKING WATER STUDY by Guo, Tai L., McCay, J. Ann, Karrow, Neil A., Brown, Ronnetta D., Musgrove, Deborah L., Luebke, Robert W., Germolec, Dori R., White, Kimber L.

“…Bromate is one of the water disinfection by-products (DBPs) produced during the process of ozonation. The purpose of this study was to evaluate the immunotoxic…”
Get full text

EVALUATION OF THE IMMUNOMODULATORY EFFECTS OF THE DISINFECTION BY-PRODUCT, SODIUM CHLORITE, IN FEMALE B6C3F1 MICE: A DRINKING WATER STUDY by Karrow, Niel A., Guo, Tai L., McCay, J. Ann, Johnson, Greg W., Brown, Ronnetta D., Musgrove, Debrorah L., Germolec, Dori R., Luebke, Robert W., White, Kimber L.

“…Sodium chlorite is an inorganic by-product of chlorine dioxide formed during the chlorination of drinking water. Relatively little is known about the adverse…”
Get full text

Modulation of serum complement levels following exposure to polychlorinated dibenzo-p-dioxins by White, Jr, K L, Lysy, H H, McCay, J A, Anderson, A C

“…Subchronic 14-day exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed serum total hemolytic complement activity (CH50) in female B6C3F1 mice at…”
Get more information

Immunosuppression without liver induction by subchronic exposure to 2,7-dichlorodibenzo-p-dioxin in adult female B6C3F1 mice by Holsapple, M P, McCay, J A, Barnes, D W

“…The overall objective of this investigation was to begin to characterize the structure-activity relationship associated with dioxin-induced suppression of…”
Get more information

Immunotoxicity of 2′,3′-Dideoxyinosine in Female B6C3F1 Mice by Phillips, Kathleen E., McCay, J. Ann, Brown, Ronnetta D., Musgrove, Deborah L., Meade, B. Jean, Butterworth, Leon F., Wilson, Susan, White, Kimber L., Munson, Albert E.

“…ABSTRACT 2′,3′-dideoxyinosine (ddI) is one of several purine analogues used for the treatment of HIV and the acquired immunodeficiency syndrome (AIDS). These…”
Get full text

A comparison of three nucleoside analogs with anti-retroviral activity on immune and hematopoietic functions in mice: in vitro toxicity to precursor cells and microstromal environment by Luster, M I, Germolec, D R, White, Jr, K L, Fuchs, B A, Fort, M M, Tomaszewski, J E, Thompson, M, Blair, P C, McCay, J A, Munson, A E

“…A number of 2'3'-dideoxynucleosides have been reported to markedly inhibit the in vitro growth of HIV, the causative agent of acquired immunodeficiency…”
Get more information

Effects of CI-949, a novel antiallergy agent, on immune function of male Fischer 344 rats by Bleavins, M R, de la Iglesia, F A, Munson, A E, McCay, J A, Stern, M L, Fuchs, B A, White, Jr, K L

“…CI-949 is an orally effective inhibitor of allergic mediator release as measured with in vitro and animal models. To assess the effects of CI-949 on immune…”
Get more information

Direct suppression of antibody responses by chlorinated dibenzodioxins in cultured spleen cells from (C57BL/6 x C3H)F1 and DBA/2 mice by Holsapple, M P, Dooley, R K, McNerney, P J, McCay, J A

“…Direct addition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 5-20 nM) to cultures of spleen cells from (C57BL/6 x C3H)F1 (B6C3F1) mice produced a suppression…”
Get more information

Dermal exposure to cinnamaldehyde alters lymphocyte subpopulations, number of interferon-gamma-producing cells, and expression of B7 costimulatory molecules and cytokine messenger RNAs in auricular lymph nodes of B6C3F1 mice by Karrow, N A, Leffel, E K, Guo, T L, Zhang, L X, McCay, J A, Germolec, D R, White, Jr, K L

“…Although the Murine Local Lymph Node Assay (LLNA) is efficient in identifying chemicals with sensitizing potential, there is increasing need for alternative…”
Get more information

An immunotoxicological evaluation of 4,4'-thiobis-(6-t-butyl-m-cresol) in female B6C3F1 mice. 2. Humoral and cell-mediated immunity, macrophage function, and host resistance by Holsapple, M P, White, Jr, K L, McCay, J A, Bradley, S G, Munson, A E

“…Adult female B6C3F1 mice were gavaged with TBBC in corn oil at doses of 10, 100, or 200 mg/kg daily for 14 consecutive days. All immunological parameters were…”
Get more information