Search Results - "McCaw, James"
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Infectious disease pandemic planning and response: Incorporating decision analysis
Published in PLoS medicine (01-01-2020)“…Freya Shearer and co-authors discuss the use of decision analysis in planning for infectious disease pandemics…”
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Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance
Published in PLoS biology (01-04-2015)“…Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins…”
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Modelling within-host macrophage dynamics in influenza virus infection
Published in Journal of theoretical biology (07-01-2021)“…•A model of influenza infection including macrophage dynamics is proposed.•The relationship between viral shedding and macrophage activation is…”
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How effective were Australian Quarantine Stations in mitigating transmission aboard ships during the influenza pandemic of 1918-19?
Published in PLoS computational biology (01-11-2023)“…The influenza pandemic of 1918-19 was the most devastating pandemic of the 20th century. It killed an estimated 50-100 million people worldwide. In late 1918,…”
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Choice of spatial discretisation influences the progression of viral infection within multicellular tissues
Published in Journal of theoretical biology (21-09-2023)“…There has been an increasing recognition of the utility of models of the spatial dynamics of viral spread within tissues. Multicellular models, where cells are…”
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The Mechanisms for Within-Host Influenza Virus Control Affect Model-Based Assessment and Prediction of Antiviral Treatment
Published in Viruses (26-07-2017)“…Models of within-host influenza viral dynamics have contributed to an improved understanding of viral dynamics and antiviral effects over the past decade…”
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Enhanced viral infectivity and reduced interferon production are associated with high pathogenicity for influenza viruses
Published in PLoS computational biology (09-02-2023)“…Epidemiological and clinical evidence indicates that humans infected with the 1918 pandemic H1N1 influenza virus and highly pathogenic avian H5N1 influenza…”
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Spatial information allows inference of the prevalence of direct cell-to-cell viral infection
Published in PLoS computational biology (23-07-2024)“…The role of direct cell-to-cell spread in viral infections-where virions spread between host and susceptible cells without needing to be secreted into the…”
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Hypnozoite dynamics for Plasmodium vivax malaria: The epidemiological effects of radical cure
Published in Journal of theoretical biology (21-03-2022)“…•Stochastic, within-host model of P. vivax burden in an endemic setting.•Construct a network of infinite server queues to model hypnozoite…”
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Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A(H1N1)pdm09 influenza viruses
Published in PLoS pathogens (01-04-2014)“…Oseltamivir is relied upon worldwide as the drug of choice for the treatment of human influenza infection. Surveillance for oseltamivir resistance is routinely…”
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Mathematical models of Plasmodium vivax transmission: A scoping review
Published in PLoS computational biology (14-03-2024)“…Plasmodium vivax is one of the most geographically widespread malaria parasites in the world, primarily found across South-East Asia, Latin America, and parts…”
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Superinfection and the hypnozoite reservoir for Plasmodium vivax: a general framework
Published in Journal of mathematical biology (01-01-2024)“…A characteristic of malaria in all its forms is the potential for superinfection (that is, multiple concurrent blood-stage infections). An additional…”
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Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
Published in Nature communications (26-02-2018)“…Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circulating CD8 + T-cell profiles from patients hospitalized with…”
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Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
Published in Proceedings of the National Academy of Sciences - PNAS (26-03-2013)“…Reports of emerging resistance to first-line artemisinin antimalarials make it critical to define resistance mechanisms and identify in vitro correlates of…”
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A hybrid transmission model for Plasmodium vivax accounting for superinfection, immunity and the hypnozoite reservoir
Published in Journal of mathematical biology (01-07-2024)“…Malaria is a vector-borne disease that exacts a grave toll in the Global South. The epidemiology of Plasmodium vivax , the most geographically expansive agent…”
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Early analysis of the Australian COVID-19 epidemic
Published in eLife (13-08-2020)“…As of 1 May 2020, there had been 6808 confirmed cases of COVID-19 in Australia. Of these, 98 had died from the disease. The epidemic had been in decline since…”
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Coronavirus Disease Model to Inform Transmission-Reducing Measures and Health System Preparedness, Australia
Published in Emerging infectious diseases (01-12-2020)“…The ability of health systems to cope with coronavirus disease (COVID-19) cases is of major concern. In preparation, we used clinical pathway models to…”
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Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages
Published in The Journal of infectious diseases (30-01-2018)“…Using a ferret model of human influenza, we demonstrate that infection with one influenza B virus can prevent or limit infection with an influenza B virus of…”
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Investigating Viral Interference Between Influenza A Virus and Human Respiratory Syncytial Virus in a Ferret Model of Infection
Published in The Journal of infectious diseases (02-07-2018)“…Epidemiological studies have observed that the seasonal peak incidence of influenza virus infection is sometimes separate from the peak incidence of human…”
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Within‐host modeling of blood‐stage malaria
Published in Immunological reviews (01-09-2018)“…Summary Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmodium falciparum, is…”
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