Search Results - "McCaughey, Laura C."

Multiple holins contribute to extracellular DNA release in Pseudomonas aeruginosa biofilms by Hynen, Amelia L, Lazenby, James J, Savva, George M, McCaughey, Laura C, Turnbull, Lynne, Nolan, Laura M, Whitchurch, Cynthia B

“…Bacterial biofilms are composed of aggregates of cells encased within a matrix of extracellular polymeric substances (EPS). One key EPS component is…”
Get full text

Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa by McCaughey, Laura C, Josts, Inokentijs, Grinter, Rhys, White, Paul, Byron, Olwyn, Tucker, Nicholas P, Matthews, Jacqueline M, Kleanthous, Colin, Whitchurch, Cynthia B, Walker, Daniel

“…Increasing rates of antibiotic resistance among Gram-negative pathogens such as Pseudomonas aeruginosa means alternative approaches to antibiotic development…”
Get more information

Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor by McCaughey, Laura C, Grinter, Rhys, Josts, Inokentijs, Roszak, Aleksander W, Waløen, Kai I, Cogdell, Richard J, Milner, Joel, Evans, Tom, Kelly, Sharon, Tucker, Nicholas P, Byron, Olwyn, Smith, Brian, Walker, Daniel

“…Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel…”
Get full text

Structural and biophysical analysis of nuclease protein antibiotics by Klein, Alexander, Wojdyla, Justyna Aleksandra, Joshi, Amar, Josts, Inokentijs, McCaughey, Laura C, Housden, Nicholas G, Kaminska, Renata, Byron, Olwyn, Walker, Daniel, Kleanthous, Colin

“…Protein antibiotics (bacteriocins) are a large and diverse family of multidomain toxins that kill specific Gram-negative bacteria during intraspecies…”
Get more information

Exploitation of an iron transporter for bacterial protein antibiotic import by White, Paul, Joshi, Amar, Rassam, Patrice, Housden, Nicholas G., Kaminska, Renata, Goult, Jonathan D., Redfield, Christina, McCaughey, Laura C., Walker, Daniel, Mohammed, Shabaz, Kleanthous, Colin

“…Unlike their descendants, mitochondria and plastids, bacteria do not have dedicated protein import systems. However, paradoxically, import of protein…”
Get full text

ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides by Nolan, Laura M, McCaughey, Laura C, Merjane, Jessica, Turnbull, Lynne, Whitchurch, Cynthia B

“…Twitching motility-mediated biofilm expansion occurs via coordinated, multi-cellular collective behaviour to allow bacteria to actively expand across surfaces…”
Get full text

Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection by McCaughey, Laura C., Ritchie, Neil. D., Douce, Gillian R., Evans, Thomas J., Walker, Daniel

“…Protein antibiotics, known as bacteriocins, are widely produced by bacteria for intraspecies competition. The potency and targeted action of bacteriocins…”
Get full text

Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake by Grinter, Rhys, Josts, Inokentijs, Zeth, Kornelius, Roszak, Aleksander W., McCaughey, Laura C., Cogdell, Richard J., Milner, Joel J., Kelly, Sharon M., Byron, Olwyn, Walker, Daniel

“…Summary The colicin‐like bacteriocins are potent protein antibiotics that have evolved to efficiently cross the outer membrane of Gram‐negative bacteria by…”
Get full text

Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146 by Agbowuro, Ayodeji A., Mazraani, Rami, McCaughey, Laura C., Huston, Wilhelmina M., Gamble, Allan B., Tyndall, Joel D.A.

“…JO146, a mixture of two diastereomers of a peptidic phosphonate inhibitor for Chlamydial HtrA (CtHtrA), has reported activity against Chlamydia species in both…”
Get full text

Structure of the atypical bacteriocin pectocin M 2 implies a novel mechanism of protein uptake by Grinter, Rhys, Josts, Inokentijs, Zeth, Kornelius, Roszak, Aleksander W., McCaughey, Laura C., Cogdell, Richard J., Milner, Joel J., Kelly, Sharon M., Byron, Olwyn, Walker, Daniel

“…Summary The colicin‐like bacteriocins are potent protein antibiotics that have evolved to efficiently cross the outer membrane of Gram‐negative bacteria by…”
Get full text

Lectin-Like Bacteriocins from Pseudomonas spp. Utilise D-Rhamnose Containing Lipopolysaccharide as a Cellular Receptor: e1003898 by McCaughey, Laura C, Grinter, Rhys, Josts, Inokentijs, Roszak, Aleksander W, Waløen, Kai I, Cogdell, Richard J, Milner, Joel, Evans, Tom, Kelly, Sharon, Tucker, Nicholas P, Byron, Olwyn, Smith, Brian, Walker, Daniel

“…Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel…”
Get full text

The development of pyocins as novel antimicrobials for the treatment of pseudomonas aeruginosa lung infection by McCaughey, Laura C

Get full text