Search Results - "McCaughan, Geoff"

Ledipasvir and sofosbuvir plus ribavirin in patients with genotype 1 or 4 hepatitis C virus infection and advanced liver disease: a multicentre, open-label, randomised, phase 2 trial by Manns, Michael, Prof, Samuel, Didier, Prof, Gane, Edward J, Prof, Mutimer, David, Prof, McCaughan, Geoff, Prof, Buti, Maria, Prof, Prieto, MartÍn, MD, Calleja, José Luis, MD, Peck-Radosavljevic, Markus, Prof, Müllhaupt, Beat, Prof, Agarwal, Kosh, MD, Angus, Peter, Prof, Yoshida, Eric M, MD, Colombo, Massimo, Prof, Rizzetto, Mario, Prof, Dvory-Sobol, Hadas, PhD, Denning, Jill, MA, Arterburn, Sarah, MS, Pang, Phillip S, MD, Brainard, Diana, MD, McHutchison, John G, MD, Dufour, Jean-François, MD, Van Vlierberghe, Hans, Prof, van Hoek, Bart, Prof, Forns, Xavier, MD

“…Summary Background Treatment options are limited for patients infected by hepatitis C virus (HCV) with advanced liver disease. We assessed the safety and…”
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International Liver Transplantation Society Consensus Statement on Hepatitis C Management in Liver Transplant Candidates by Terrault, Norah A, McCaughan, Geoff W, Curry, Michael P, Gane, Edward, Fagiuoli, Stefano, Fung, James Y Y, Agarwal, Kosh, Lilly, Les, Strasser, Simone I, Brown, Kimberly A, Gadano, Adrian, Kwo, Paul Y, Burra, Patrizia, Samuel, Didier, Charlton, Michael, Pessoa, Mario G, Berenguer, Marina

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Grade of deceased donor liver macrovesicular steatosis impacts graft and recipient outcomes more than the Donor Risk Index by de Graaf, Esther L, Kench, James, Dilworth, Pamela, Shackel, Nicholas A, Strasser, Simone I, Joseph, David, Pleass, Henry, Crawford, Michael, McCaughan, Geoff W, Verran, Deborah J

“…Background and Aim:  Donor liver steatosis can impact on liver allograft outcomes. The aim of the present study was to comprehensively report on the impact of…”
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A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt by Sievert, William, Altraif, Ibrahim, Razavi, Homie A., Abdo, Ayman, Ahmed, Ezzat Ali, AlOmair, Ahmed, Amarapurkar, Deepak, Chen, Chien-Hung, Dou, Xiaoguang, El Khayat, Hisham, elShazly, Mohamed, Esmat, Gamal, Guan, Richard, Han, Kwang-Hyub, Koike, Kazuhiko, Largen, Angela, McCaughan, Geoff, Mogawer, Sherif, Monis, Ali, Nawaz, Arif, Piratvisuth, Teerha, Sanai, Faisal M., Sharara, Ala I., Sibbel, Scott, Sood, Ajit, Suh, Dong Jin, Wallace, Carolyn, Young, Kendra, Negro, Francesco

“…Background: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem…”
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Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88‐dependent acceleration of hyperlipidaemia by Gram‐positive cell wall components by Manuneedhi Cholan, Pradeep, Morris, Simone, Luo, Kaiming, Chen, Jinbiao, Boland, Jade A., McCaughan, Geoff W., Britton, Warwick J., Oehlers, Stefan H.

“…Gut dysbiosis is an important modifier of pathologies including cardiovascular disease but our understanding of the role of individual microbes is limited…”
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International Liver Transplantation Society Consensus Statement on Hepatitis C Management in Liver Transplant Recipients by Terrault, Norah A, Berenguer, Marina, Strasser, Simone I, Gadano, Adrian, Lilly, Les, Samuel, Didier, Kwo, Paul Y, Agarwal, Kosh, Curry, Michael P, Fagiuoli, Stefano, Fung, James Y Y, Gane, Edward, Brown, Kimberly A, Burra, Patrizia, Charlton, Michael, Pessoa, Mario G, McCaughan, Geoff W

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miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer by Brockhausen, Jennifer, Tay, Szun S., Grzelak, Candice A., Bertolino, Patrick, Bowen, David G., d'Avigdor, William M., Teoh, Narcy, Pok, Sharon, Shackel, Nick, Gamble, Jennifer R., Vadas, Mathew, McCaughan, Geoff W.

“…Background & Aims Epithelial–mesenchymal transition (EMT) has been implicated in the processes of embryogenesis, tissue fibrosis and carcinogenesis…”
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Outcomes for children after second liver transplantations are similar to those after first transplantations: a binational registry analysis by Jeffrey, Angus W, Jeffrey, Gary P, Stormon, Michael, Thomas, Gordon, O'Loughlin, Edward, Shun, Albert, Hardikar, Winita, Jones, Robert, McCall, John, Evans, Helen, Starkey, Graham, Hodgkinson, Peter, Ee, Looi C, Moore, David, Mews, Catherine, McCaughan, Geoff W, Angus, Peter W, Wigg, Alan J, Crawford, Michael, Fawcett, Jonathan

“…Objective To assess long term graft and patient survival after donor liver retransplantation in children in Australia and New Zealand during 1986–2017; to…”
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Hepatitis C virus drug resistance and immune‐driven adaptations: Relevance to new antiviral therapy by Gaudieri, Silvana, Rauch, Andri, Pfafferott, Katja, Barnes, Eleanor, Cheng, Wendy, McCaughan, Geoff, Shackel, Nick, Jeffrey, Gary P., Mollison, Lindsay, Baker, Ross, Furrer, Hansjakob, Günthard, Huldrych F., Freitas, Elizabeth, Humphreys, Isla, Klenerman, Paul, Mallal, Simon, James, Ian, Roberts, Stuart, Nolan, David, Lucas, Michaela

“…The efficacy of specifically targeted anti‐viral therapy for hepatitis C virus (HCV) (STAT‐C), including HCV protease and polymerase inhibitors, is limited by…”
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Longitudinal immunosuppression data can minimize misclassification bias in solid organ transplantation cohorts by Laaksonen, Maarit A., Webster, Angela C., McCaughan, Geoff W., Keogh, Anne M., Grulich, Andrew E., Vajdic, Claire M.

“…Background Most cohort studies investigating the effect of immunosuppression on transplant outcomes use drugs at first hospital discharge. We evaluated the…”
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Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update by Liaw, Yun-Fan, Leung, Nancy, Guan, Richard, Lau, George K.K., Merican, Ismail, McCaughan, Geoff, Gane, Edward, Kao, Jia-Horng, Omata, Masao

“…:
 Background/Aims: A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires…”
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Efficacy of albumin use in decompensated cirrhosis and real‐world adoption in Australia by Kalo, Eric, Read, Scott, Baig, Asma, Marshall, Kate, Ma, Wai‐See, Crowther, Helen, Gofton, Cameron, Lynch, Kate D, Sood, Siddharth, Holmes, Jacinta, Lubel, John, Wigg, Alan, McCaughan, Geoff, Roberts, Stuart K, Caraceni, Paolo, Ahlenstiel, Golo, Majumdar, Avik

“…The current treatment approach to patients with liver cirrhosis relies on the individual management of complications. Consequently, there is an unmet need for…”
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Distinct pretreatment innate immune landscape and posttreatment T cell responses underlie immunotherapy-induced colitis by Nahar, Kazi J, Marsh-Wakefield, Felix, Rawson, Robert V, Gide, Tuba N, Ferguson, Angela L, Allen, Ruth, Quek, Camelia, da Silva, Ines Pires, Tattersal, Stephen, Kiely, Christopher J, Sandanayake, Neomal, Carlino, Matteo S, McCaughan, Geoff, Wilmott, James S, Scolyer, Richard A, Long, Georgina V, Menzies, Alexander M, Palendira, Umaimainthan

“…Immune-related adverse events represent a major hurdle to the success of immunotherapy. The immunological mechanisms underlying their development and relation…”
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The Hidden Epidemic: The Prevalence and Impact of Concurrent Liver Diseases in Patients Undergoing Liver Transplantation in Australia and New Zealand by Howell, Jess, Majumdar, Avik, Fink, Michael, Byrne, Mandy, McCaughan, Geoff, Strasser, Simone I., Crawford, Michael, Hodgkinson, Peter, Stuart, Katherine A., Tallis, Caroline, Chen, John, Wigg, Alan, Jones, Robert, Jaques, Bryon, Jeffrey, Gary, Adams, Leon, Wallace, Michael C., Gane, Ed, Thompson, Alex, Gow, Paul

“…Prevalence of concurrent liver diseases among liver transplant recipients and impact on posttransplant outcomes are unknown. This retrospective study included…”
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Alcoholic Liver Disease in Asia, Europe, and North America by Liangpunsakul, Suthat, Haber, Paul, McCaughan, Geoff

“…Alcoholic liver diseases comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from…”
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Autonomic and peripheral neuropathy in endstage liver disease and following liver transplantation by McDougall, Alan J., Davies, Leo, McCaughan, Geoff W.

“…Severe chronic liver disease may be associated with a peripheral somatic and an autonomic neuropathy. There are only a limited number of reports on the…”
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Those Donor Leucocytes Again? This Time It’s VITT by Tavabie, Oliver D., McCaughan, Geoff, Aluvihare, Varuna R.

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SAT-036-YI Impact of distance from liver transplant centre on outcomes following liver transplantation-an australian single centre study by Chin, Simone, Kench, Charlotte, Cao, Rena, Lee, Christina, Virtue, Susan, West, Claire, Valliani, Talal, Bowen, David, Strasser, Simone, McCaughan, Geoff, Liu, Ken

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OS-024 The gender-equity model for liver allocation built on artificial intelligence (GEMA-AI) improves outcome predictions among liver transplant candidates by Rodríguez-Perálvarez, Manuel, Gómez-Orellana, Antonio M., Guijo-Rubio, David, Gutierrez, Pedro, Majumdar, Avik, McCaughan, Geoff, Taylor, Rhiannon, Hervás, César, Tsochatzis, Emmanuel

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WED-267 The FAP Index: A statistical model aiding the detection of advanced liver fibrosis in people with diabetes, obesity or metabolic dysfunction-associated steatosis using a marker of activated stellate cells and myofibroblasts by Wang, Ziqi Vincent, Boumelhem, Badwi, Bachovchin, William, Ooi, Geraldine, George, Jacob, Eslam, Mohammed, Adams, Leon, Zhang, Hui, McCaughan, Geoff, Majumdar, Avik, Gorrell, Mark

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